DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and PTPRK

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_001278910.1 Gene:PTPRK / 5796 HGNCID:9674 Length:1462 Species:Homo sapiens


Alignment Length:1200 Identity:287/1200 - (23%)
Similarity:449/1200 - (37%) Gaps:343/1200 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   631 VHTNLVVLHW---QAPEGSDFSEYVVRYRTDASPWQR----ISGLHENEARIKD---MHYGERYL 685
            ||.:....|:   :.|:||    |::...:|..|.::    :..:.||:....|   :.|.::.|
Human    58 VHVSAQEPHYLPPEMPQGS----YMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGL 118

  Fly   686 VQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLT-LEWPRPDGHVDFYTLKWWPTDEE- 748
                       :|..|.:.|.:...|::|  |:.:....| .:|.|.:..|..:    ||.:.: 
Human   119 -----------NPGTLNILVRVNKGPLAN--PIWNVTGFTGRDWLRAELAVSTF----WPNEYQV 166

  Fly   749 --------DRVEFKNVTQLEDLSSPS------VRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLS 799
                    .|..:..:..::.||.|.      :|:...:::.|:...|:..|:..........|.
Human   167 IFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQ 231

  Fly   800 TRT---MPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYR----FSMGDPTIKDKEKL 857
            .|.   :|:.|:    .|..|.:     ...|:.......|..|:||    ...|.......:.:
Human   232 RRNGEDIPVAQT----KNINHRR-----FAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLI 287

  Fly   858 ANDTERKLS---FSGLTPGKL---------------------YNVT--VWTVSGGVASLPVQRLY 896
            ..:..|.::   ..|:.|..|                     |.:|  .||.:..| :.|..:|:
Human   288 VREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAV-NAPTYKLW 351

  Fly   897 RLHP-------------------LP----------------ISDLKAIQVAAREITLHWTAPAGE 926
            .|.|                   ||                ...||..::.||.|.:.|.:....
Human   352 HLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYN 416

  Fly   927 YT------------------DFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRS 973
            .|                  :.:...|..|.:|||.:.|          .|.||.|.:..::   
Human   417 ITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVN----------HLPPYTNVSLKMI--- 468

  Fly   974 GSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVD----YFQPSDVQPGEV--------TFE 1026
                                         ||.|.|:.:    ..|..:..||.|        :||
Human   469 -----------------------------LTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFE 504

  Fly  1027 ------WSLEPAEQHGPIDYFRI---TCQNADDAADVSSYEFPV----NATQGKIDGLVPGNHYI 1078
                  |. ||.:.:|.|..:.|   :.::.|.|..|:.....|    |:|......|.||..|.
Human   505 NKIFLNWK-EPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQ 568

  Fly  1079 FRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYT 1143
            |.|:|.:..|:|.......|..|.||.:|:.......::.|::||.:..|......|  .:.:|.
Human   569 FFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGA--PISAYQ 631

  Fly  1144 IIIAE----DVGKNASGLEMPSWQDVQAYTVWLPYQ-AIEPYNPFLTSNGSRKSSL-EAEHFTIG 1202
            |::.|    ...:.|..:|        .|.|.:.|| |:....|:..:......:| |...||:|
Human   632 IVVEELHPHRTKREAGAME--------CYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVG 688

  Fly  1203 TANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT----VYSSPITTE----------RSDT 1253
            .   ::...|:.|.||.....|.|..:|.:..:|.|.|    :.:....||          ::|.
Human   689 D---NRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDR 750

  Fly  1254 VIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLAR------------MQDELAALPEGY---- 1302
            |:..|.:||.:||.::|::|..     ||.:.||||:            |...:.|:...|    
Human   751 VVKIAGISAGILVFILLLLVVI-----LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQS 810

  Fly  1303 ---------IT-----------PNRP--------------------------------------- 1308
                     ||           ||.|                                       
Human   811 TLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTESPY 875

  Fly  1309 --------VHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPY 1365
                    :.|.|..:|..:|.....:.|.||:|.. ..|:..:...|....||.|||:.||:.|
Human   876 QTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAY 939

  Fly  1366 DHSRFKLQPVDDDDGSDYINANYM------PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAI 1424
            ||||..||||:||..||||||||:      .|:..|..:|.||||:|.|..:||||.|:..|..|
Human   940 DHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACI 1004

  Fly  1425 VMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFH 1487
            ||:|...|.||.||.:|||.|  ...|||.||..:......::.:..|.:.|.  .|.|.::.||
Human  1005 VMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFH 1067

  Fly  1488 FTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVD 1552
            ||.|||.|||.....|:.|:|..:........||:||||||.||:|.:|.:|.:|....:...||
Human  1068 FTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD 1132

  Fly  1553 IFGIVFAMRKERVFMVQTEQQYVCIHQCLL 1582
            |:..|.|:|..|:.|||||:||:.||..:|
Human  1133 IYNCVKALRSRRINMVQTEEQYIFIHDAIL 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628
fn3 247..328 CDD:394996
FN3 319..>749 CDD:442628 26/137 (19%)
fn3 708..796 CDD:394996 17/103 (17%)
fn3 902..978 CDD:394996 18/109 (17%)
fn3 1013..1092 CDD:394996 27/99 (27%)
PTP_tm 1127..1247 CDD:465889 28/129 (22%)
R3-PTPc 1358..1579 CDD:350396 101/228 (44%)
PTPRKNP_001278910.1 MAM 32..192 CDD:214533 29/154 (19%)
IG_like 202..288 CDD:214653 15/94 (16%)
Ig strand B 212..216 CDD:409353 1/3 (33%)
Ig strand C 226..232 CDD:409353 1/5 (20%)
Ig strand E 253..257 CDD:409353 1/3 (33%)
Ig strand F 267..272 CDD:409353 2/4 (50%)
fn3 294..371 CDD:394996 12/77 (16%)
fn3 488..583 CDD:394996 26/95 (27%)
PTP_DSP_cys 888..1166 CDD:475123 115/277 (42%)
R-PTPc-K-2 1252..1457 CDD:350484
Blue background indicates that the domain is not in the aligned region.

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