DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and PTPRF

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_005271136.1	Gene:	PTPRF / 5792	HGNCID:	9670	Length:	1922	Species:	Homo sapiens

Alignment Length:	1769	Identity:	398/1769 - (22%)
Similarity:	647/1769 - (36%)	Gaps:	500/1769 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 ITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESV 233
            |||...|. :.|..|..|:...|                      ..|...::|...|.:.:...
Human    64 ITWMKKGK-KVSSQRFEVIEFDD----------------------GAGSVLRIQPLRVQRDEAIY 105

  Fly   234 AYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPD----DAIQSVLYVER 294
            ..|:.|...:.||..|          |.||.:...|.|..:   :.:.|.    :..::...:..
Human   106 ECTATNSLGEINTSAK----------LSVLEEEQLPPGFPS---IDMGPQLKVVEKARTATMLCA 157

  Fly   295 EGEPPGPAQAAFKGLVP-------GREYNI---SVQTVSEDETSSVPTTARYLTVPERVLNVTFD 349
            .|..|.|..:.||..:|       ||...:   ::|..|.:|:..    .:|
Human   158 AGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQ----GKY------------- 205

  Fly   350 EAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRI---FNVPRAANGDSVYFDYPDILEPGRTYE 411
            |...|:|: ..|:..|......|..:|     ||:   |::|.::.         ::: ||.:..
Human   206 ECVATNSA-GTRYSAPANLYVRDQREV-----RRVAPRFSIPPSSQ---------EVM-PGGSVN 254

  Fly   412 VVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNA 476
            :....:.              .|.|               ::.|           .:...|.|..
Human   255 LTCVAVG--------------APMP---------------YVKW-----------MMGAEELTKE 279

  Fly   477 SEVPAPFPVAAESQITTNLTEYTLDSLLAGRRY-LIAVQALSKGVASNASDITRYTRPAAPL-IQ 539
            .|:|          :..|:.|  |.:::....| .:|:.:|  |:....:.:|....|..|: :.
Human   280 DEMP----------VGRNVLE--LSNVVRSANYTCVAISSL--GMIEATAQVTVKALPKPPIDLV 330

  Fly   540 ELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGT----REERTMATNETSLTIHYLHPGSGYEVKV 600
            ...:....:.|:|.|..:.....|.:.|:..||    :|...:||  |..:|..|.|.|.|..:|
Human   331 VTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVAT--TRYSIGGLSPFSEYAFRV 393

  Fly   601 HAISHGVRSEPHSYFQA-----VFPKPPQNLTLQTVHTNLVVLHWQAPEGSD--FSEYVVRYRTD 658
            .|::...|..|....:|     ....||:.:..:.:..:.:::.|:.||..:  ...|.|.|..|
Human   394 LAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPD 458

  Fly   659 A----SPWQRISGLHENEA----RIKDMHYGERYLVQV---NTVSFGVESPH-PLELNVTMPPQP 711
            :    :.|.:    |..:|    .:..:..|..|.::|   ..|..|..||. .::....:|.||
Human   459 SRRPPNAWHK----HNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQP 519

  Fly   712 VSNVVPLVDSRNLTLEW--PRPDGHVDFYTLKWWPTDEED---RVEFKNVTQLEDLSSPSVRIPI 771
            ......:.....:.|.|  | |...:..|.|.:|..::||   :|.|          .|:....:
Human   520 ADFQAEVESDTRIQLSWLLP-PQERIIMYELVYWAAEDEDQQHKVTF----------DPTSSYTL 573

  Fly   772 EDLSPGRQYRFEVQASSN-GIRSGTTHLSTRTMPLIQS----DVFIANAGHEQGQDETITLSYTP 831
            |||.|...|||::.|.|: |:...|..:..||.....|    .|...:.|     ..|:.:|:.|
Human   574 EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG-----STTVRVSWVP 633

  Fly   832 TPADSTRFDIYRFSMGDPTIKDKEK---LANDTERKLS---FSGLTPGKLYNVTVWT-----VSG 885
            .||||....|.::|:....:..:::   :.:...|:.|   ..||.....|.  ||.     |..
Human   634 PPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR--VWVRAHTDVGP 696

  Fly   886 GVASLPVQRLYRL-HPLPISDLKAIQVA---AREITLHWTAPA-----GEYTDFELQYLSADEEA 941
            |..|.||  |.|. ..:|....:.::|.   :..:.::|..|.     |:...:::.|:..:...
Human   697 GPESSPV--LVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE 759

  Fly   942 PQ---LLQNV-----------TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRS 992
            |:   ::|:|           :::.|.|:.||.|...|:.||...:....|.           ||
Human   760 PRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGA-----------RS 813

  Fly   993 SAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSY 1057
            ...|   ..|..|.||: .....|.........:|. .|.|..|.:..:|:....||:|.. ::.
Human   814 KPKI---VTTTGAVPGR-PTMMISTTAMNTALLQWH-PPKELPGELLGYRLQYCRADEARP-NTI 872

  Fly  1058 EFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAERE-HIQTMPILAPPVPEP-SVTPLEVSRTS 1120
            :|..:.....:.||..|..||||:.||:..|.|.|.| .|:|...|....|:. .||.|    |:
Human   873 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL----TT 933

  Fly  1121 STIEISFRQGYFSNAHGMVRSYTII------------IAEDVGKNASGLE--------------- 1158
            ||.|:::.....:..:|.:.|||::            |..|.....:||:
Human   934 STTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSK 998

  Fly  1159 -------------MP---------------------SWQDVQAYTVWLPY------QAIE----- 1178
                         ||                     ||:...:|...:|:      |::|
Human   999 GSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHS 1063

  Fly  1179 -----------------------------------------PYNP-------------------- 1182
                                                     |:.|
Human  1064 MRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQ 1128

  Fly  1183 ---------------------FLTSNGSRKSSLE------------------------------- 1195
                                 .||...|....||
Human  1129 DPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA 1193

  Fly  1196 -----AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAF----TDEDKFTDTVYSSPITT--- 1248
                 .|.||:|.   .|:..|:.|.||....:|:..:.|.    .|:.::..:.||..|..
Human  1194 QLDVLPETFTLGD---KKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVT 1255

  Fly  1249 -----ERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK-----------LARMQDELAA 1297
                 |..:.:.|...|.||:|:.::::.:....|.:....:||           ||...|.:..
Human  1256 PAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEM 1320

  Fly  1298 LPEGYITP---------------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSF 1347
            ....|.||               :.|:.:.|.:::...:.|:...:||:|:|.: ..|:......
Human  1321 RRLNYQTPGSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1384

  Fly  1348 ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEF 1412
            :||..|:||||:.|::.|||||..|..:|...|||||||||:.|:.....:|.|||||..|..:|
Human  1385 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1449

  Fly  1413 WRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV--S 1475
            |||.||..:..:||:||..||.|.|||||||. |.....|.|:|.|:.......:::..|.:  |
Human  1450 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATYTVRTFALHKS 1513

  Fly  1476 RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDR 1540
            .:.|.|.:|.|.|..|||.||||.|..::.|:|..:.....|..|::|||||||||:|.||.:|.
Human  1514 GSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1578

  Fly  1541 ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELHAN--- 1601
            :|:.:.....|||:|.|..||.:|.:|||||.|||.||:.|| |...|...:.|.:|..|..
Human  1579 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLG 1643

  Fly  1602 ---DGYEVTKIYLE 1612
               .|..||.:.||
Human  1644 QVPPGESVTAMELE 1657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	13/72 (18%)
		fn3	247..328	CDD:278470	18/94 (19%)
		fn3	343..417	CDD:278470	13/76 (17%)
		fn3	443..525	CDD:278470	12/82 (15%)
		FN3	548..611	CDD:238020	19/66 (29%)
		FN3	620..706	CDD:238020	19/99 (19%)
		fn3	708..796	CDD:278470	25/93 (27%)
		fn3	824..886	CDD:278470	17/72 (24%)
		fn3	902..978	CDD:278470	17/97 (18%)
		fn3	1013..1092	CDD:278470	21/78 (27%)
		UP_III_II	1106..>1248	CDD:297589	46/336 (14%)
		PTPc	1329..1582	CDD:214550	113/254 (44%)
		PTPc	1355..1582	CDD:238006	105/228 (46%)
PTPRF	XP_005271136.1	I-set	33..124	CDD:254352	17/92 (18%)
		Ig	50..121	CDD:143165	15/79 (19%)
		I-set	135..225	CDD:254352	18/110 (16%)
		Ig2_RPTP_IIa_LAR_like	152..226	CDD:143215	17/91 (19%)
		IG_like	242..319	CDD:214653	16/140 (11%)
		Ig3_RPTP_IIa_LAR_like	250..318	CDD:143216	15/121 (12%)
		FN3	323..412	CDD:238020	23/90 (26%)
		FN3	419..511	CDD:238020	19/95 (20%)
		FN3	516..605	CDD:238020	26/99 (26%)
		fn3	613..700	CDD:278470	20/93 (22%)
		FN3	714..820	CDD:238020	20/119 (17%)
		FN3	825..914	CDD:238020	26/91 (29%)
		FN3	923..1011	CDD:238020	16/91 (18%)
		FN3	1020..>1079	CDD:238020	6/58 (10%)
		PTPc	1366..1621	CDD:214550	114/256 (45%)
		PTPc	1392..1621	CDD:238006	106/229 (46%)
		PTPc	1657..1912	CDD:214550	1/1 (100%)
		PTPc	1682..1912	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940