Protein Alignment Ptp4E and PTPRC

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_002829.3
• Gene: PTPRC / 5788
• HGNCID: 9666
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 1167
• Identity: 267/1167 - (22%)
• Similarity: 448/1167 - (38%)
• Gaps: 298/1167 - (25%)

  Fly   783 EVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMG 847
            ||..:........|.|:|..||                   ::.||..|.|..:|.|       .
Human    20 EVFVTGQSPTPSPTGLTTAKMP-------------------SVPLSSDPLPTHTTAF-------S 58

  Fly   848 DPTIKDKEKLANDTERKLS----FSGLTPGKLYNVTVWTVSGGVASLPVQRL------------- 895
            ..:..::|...::|...||    .:.::|..|.|.:.:..: ||:|:....|
Human    59 PASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTT-GVSSVQTPHLPTHADSQTPSAGT 122

  Fly   896 -----------YRLHPLP----ISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLL 945
                       .:|:|.|    |||:...:..|....   |.|....|    ..||....:...|
Human   123 DTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFP---TDPVSPLT----TTLSLAHHSSAAL 180

  Fly   946 QNVTKNTEITLQGLRPYHNYTFT--------VVVRSGSIQGT--------DFADVSVSTLMR--- 991
            ...|.||.||......|.|.:.|        .|:.:.:|..|        .:|:::|..|..
Human   181 PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKET 245

  Fly   992 -------------------------------SSAPISASYQTLTAP--------PGKVDYFQPSD 1017
                                           .:|.:|.|:.:.|||        |..|:.||..|
Human   246 KLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHD 310

  Fly  1018 ---VQPGEVT--FEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFP-----VNATQGKIDGLV 1072
               |:..:.|  .:|.        .|:.|....||.       :|.|.     .:..:.|::.|.
Human   311 CTQVEKADTTICLKWK--------NIETFTCDTQNI-------TYRFQCGNMIFDNKEIKLENLE 360

  Fly  1073 PGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGY--FSNA 1135
            |.:.|    :..|.:.|. ..:......|:......|....:...|:.:.     .||.  ::..
Human   361 PEHEY----KCDSEILYN-NHKFTNASKIIKTDFGSPGEPQIIFCRSEAA-----HQGVITWNPP 415

  Fly  1136 HGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTS-------NGSRKSS 1193
            .....::|:...::..|:...|:    :::..|.:    |.::||..::.|       ...|..|
Human   416 QRSFHNFTLCYIKETEKDCLNLD----KNLIKYDL----QNLKPYTKYVLSLHAYIIAKVQRNGS 472

  Fly  1194 LEAEHFTIGTA------------NCDKHQAGYC------NGP-------LRAGTT---------- 1223
            ....|||..:|            ..|......|      |||       :.||.|
Human   473 AAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNC 537

  Fly  1224 -YRIK-IRAFTDEDKFTDTVY-------SSPI----TTERSDTVIVAATVSAVLLVAMVLVVV-- 1273
             :|:| ::..||   :|...|       ..|.    :|..:...::|.....:::.::.|:||
Human   538 DFRVKDLQYSTD---YTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLY 599

  Fly  1274 --YCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEEL 1336
              |..|:    :|:..|...|:.:....|..:....|:|.....|.|:...||....|..||:.:
Human   600 KIYDLHK----KRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI 660

  Fly  1337 KHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVT 1401
            ..|........|..|.|:.|||:.:|||||::|.:|..::.|.||:||||:|:.|...||::|..
Human   661 PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAA 725

  Fly  1402 QGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-VDRVAMFYGDIKVQLIIDTHYH 1465
            |||...|.::||||.||..:..|||:|||.|..|.||.:||| ::.....:||:.|::.......
Human   726 QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCP 790

  Fly  1466 DWSISEFMVSRNCE---SRIMRHFHFTTWPDFGVPEPPQSLV---RFVRAFRDVIGTDMRPIIVH 1524
            |:.|.:..:....|   .|.:.|..||:|||.||||.|..|:   |.|.||.:...   .||:||
Human   791 DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS---GPIVVH 852

  Fly  1525 CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE 1589
            |||||||:||:|.:|.:|:.:...:.||::|.|..:|::|..|||.|.||:.|||.|:      |
Human   853 CSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALV------E 911

  Fly  1590 HLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRAS---LAMAEKLDADLMTNKDEDEDQEQQ 1651
            :......|::.::.:.......:|.|.::..  |:.|.   |..........:.|::|::.:.:.
Human   912 YNQFGETEVNLSELHPYLHNMKKRDPPSEPS--PLEAEFQRLPSYRSWRTQHIGNQEENKSKNRN 974

  Fly  1652 --------QQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSSTHDVH 1708
                    .:..|:...|:..:..:|.:|..:||.|.::..:.:|       :|...|....:|.
Human   975 SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYIN-------ASFIMSYWKPEVM 1032

  Fly  1709 VVLQEAIEKP----------------------KQEQERICA-----GTQSHADTESDNTDSD 1743
            :..|..:::.                      |...:.|||     |.|::.|.|.|..|:|
Human  1033 IAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTD 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996	2/12 (17%)
		fn3	902..978	CDD:394996	21/87 (24%)
		fn3	1013..1092	CDD:394996	18/88 (20%)
		PTP_tm	1127..1247	CDD:465889	31/176 (18%)
		R3-PTPc	1358..1579	CDD:350396	95/227 (42%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:403599	2/11 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..163		30/164 (18%)
		PHA03255	81..>231	CDD:165513	31/157 (20%)
		CD45	237..295	CDD:432641	8/57 (14%)
		fn3	393..462	CDD:394996	11/81 (14%)
		FN3	485..565	CDD:238020	14/82 (17%)
		R-PTPc-C-1	707..907	CDD:350405	84/202 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1014		5/20 (25%)
		R-PTP-C-2	1017..1223	CDD:350406	16/85 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1261..1306