Protein Alignment Ptp4E and PTPRB

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_006719591.1
• Gene: PTPRB / 5787
• HGNCID: 9665
• Length: 2230
• Species: Homo sapiens
• Alignment Length: 1809
• Identity: 505/1809 - (27%)
• Similarity: 763/1809 - (42%)
• Gaps: 413/1809 - (22%)

  Fly    95 PPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLT----WTVNIT------- 148
            ||......|.|:  |..| .||.||.|..     |:   ..||.::|.    :.|.::
Human   531 PPGNVDSYNITL--SHKG-TIKESRVLAP-----WI---TETHFKELVPGRLYQVTVSCVSGELS 584

  Fly   149 --------TAPDPPANLSVQLRS-SKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSL---- 200
                    |.||..|||...... .:|..::|.|| :|.:..:||       |.|..|..|
Human   585 AQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPP-AGDWEQYRI-------LLFNDSVVLLNIT 641

  Fly   201 EGNETLQ--LSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFI--------VWFR 255
            .|.|..|  :....|.||..|:|:          |...|.|........|:.:        |...
Human   642 VGKEETQYVMDDTGLVPGRQYEVE----------VIVESGNLKNSERCQGRTVPLAVLQLRVKHA 696

  Fly   256 NETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQ 320
            |||:|.::||.  |...:..|.:|:...|.:.....:.::.:     :..|..|||||:|..:|.
Human   697 NETSLSIMWQT--PVAEWEKYIISLADRDLLLIHKSLSKDAK-----EFTFTDLVPGRKYMATVT 754

  Fly   321 TVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVML------- 378
            ::|.|..:|.....|  |||.:|.::.......|||.| ..|...:...||  |||:|
Human   755 SISGDLKNSSSVKGR--TVPAQVTDLHVANQGMTSSLF-TNWTQAQGDVEF--YQVLLIHENVVI 814

  Fly   379 -------STSRRIFN------------------------------VPRAANG----DSVYFDYPD 402
                   .|||..|:                              ||.:.:|    :|...||..
Human   815 KNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLS 879

  Fly   403 I---------------------------------------LEPGRTYEVVV-------------- 414
            :                                       |.|||.|.|.:
Human   880 VSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQ 944

  Fly   415 -KTIADNVN---------------SW-PASG-----EVTLR------------------------ 433
             :|:.|.|.               || .|:|     |||::
Human   945 ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLV 1009

  Fly   434 ---------------------------PRPVRSLGGFLDDRSNA-LHISWEPAETGRQDSYRISY 470
                                       |.||:.|  .|.:||.. ||::|..| .|..|.|.|..
Human  1010 PGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDL--TLRNRSTEDLHVTWSGA-NGDVDQYEIQL 1071

  Fly   471 HEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAA 535
              ..|..:|..||      .:....|||...||..||:|.|.|..:|..|..:|. |..:|.|:|
Human  1072 --LFNDMKVFPPF------HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF-IEGFTVPSA 1127

  Fly   536 PLIQELRSIDQG----LMLSWR---SDVNSRQDRYEVHYQRNGTR-EERTMATNETSLTIHYLHP 592
              ::.:.....|    |.::|.   .||    |.|.|...|:..: :.:|:..:....|.|.|..
Human  1128 --VKNIHISPNGATDSLTVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEA 1186

  Fly   593 GSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNL-VVLHWQAPEGSD-------FS 649
            |..|::.:.::|..::::.:...:.| |...|.:.....:::. :::.||...|..       .:
Human  1187 GEQYQIMIASVSGSLKNQINVVGRTV-PASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1250

  Fly   650 EYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSN 714
            |..:..|..:.|      ....:.:.:|:..|::|.:|:.|||.|:.|........|:|......
Human  1251 ENGILLRNTSEP------ATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1309

  Fly   715 VVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDE--EDRVEFKNVTQLEDLSSPSVRIPIEDLSPG 777
            .:....:|:|:..|...:|.:.:|.:..:..|.  ::|.:...:.|         ....::|..|
Human  1310 RITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQ---------SFSFQNLLQG 1365

  Fly   778 RQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT----LSYTPTPADSTR 838
            |.|:. |..:.:|..|..:.:..||:|        |:..|.:|.:...|    .:::|...|
Human  1366 RMYKM-VIVTHSGELSNESFIFGRTVP--------ASVSHLRGSNRNTTDSLWFNWSPASGD--- 1418

  Fly   839 FDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPI 903
            ||.|...:.:|....||...:....:..|.||.||:.|.:.|.|.||.::: .|....|..|.|.
Human  1419 FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSN-KVTAESRTAPSPP 1482

  Fly   904 SDLKAIQVAAREITLHWTAPAG--EYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYT 966
            |.:....:|...:.:.|..|..  :|.|||||:|..|........|..|:....:.||||..:|.
Human  1483 SLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQ 1547

  Fly   967 FTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEP 1031
            |.|...||....|            .|.||..|.:|   .|.|:............:...| :.|
Human  1548 FNVKTVSGDSWKT------------YSKPIFGSVRT---KPDKIQNLHCRPQNSTAIACSW-IPP 1596

  Fly  1032 AEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGK----IDGLVPGNHYIFRIQAKSALGYGAE 1092
               ....|.:.|.|:.    .|....||.....:.|    |..|||...|:..|:.:|| |..:|
Human  1597 ---DSDFDGYSIECRK----MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA-GMTSE 1653

  Fly  1093 REHIQTMPIL---APPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNA 1154
            .....|:.::   .||.|...|...:|..:.|:|..:....:||:.:|.|:.:|:::.|..|.:.
Human  1654 VVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE 1718

  Fly  1155 SGLE----MPSWQD------VQAY-TVWLPYQAIEPYNPFLTSNGSRKS---SLEAEHFTIGTAN 1205
            ...|    :||:.:      ::.| |.:...:..|  ||    |.:.||   .|.||..::| ..
Human  1719 LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAE--NP----NSNSKSFNIKLGAEMESLG-GK 1776

  Fly  1206 CDKHQAGYCNGPLRAGTTYRIKIRAFT---DED--KFT-----DTVYSSPITTERSDTVIVAATV 1260
            ||..|..:|:|||:..|.|||.|||||   |||  :||     ||.:|.|||||..........|
Human  1777 CDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV 1841

  Fly  1261 SA-VLLVAMVLVVV---YCQHRCQ--LIRRASKLARMQDELAAL-----PEGYITPNRPVHVKDF 1314
            || :.|:.|::.||   .|:.:..  ..|.:::|:..:|...::     .:|....:.|:.:..|
Human  1842 SAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQF 1906

  Fly  1315 SEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDD 1379
            ..|:..:.|||::..|:|:||||.|||:|:|..|.||.||.|||:.||||||.:|.||..||||.
Human  1907 EGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDP 1971

  Fly  1380 GSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV 1444
            .||||||:|:||:|..||:|||||||..|:::||:|.||.|...|||:|:|.||||.|||.|||.
Human  1972 CSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA 2036

  Fly  1445 DRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC------ESRIMRHFHFTTWPDFGVPEPPQSL 1503
            |:.:::|||:.:|::.::...:|:|.||.:   |      ..|::||||:|.|||.||||..|||
Human  2037 DQDSLYYGDLILQMLSESVLPEWTIREFKI---CGEEQLDAHRLIRHFHYTVWPDHGVPETTQSL 2098

  Fly  1504 VRFVRAFRDVIGTD--MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVF 1566
            ::|||..||.|...  ..|.:|||||||||:|||||||||||.:...|.|||:|.|..:|..||.
Human  2099 IQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2163

  Fly  1567 MVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMG 1620
            |||||.|||.:|||:..||..:        :|.:.....:..||....|:...|
Human  2164 MVQTECQYVYLHQCVRDVLRAR--------KLRSEQENPLFPIYENVNPEYHRG 2209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	67/272 (25%)
		fn3	247..328	CDD:394996	22/88 (25%)
		FN3	319..>749	CDD:442628	124/622 (20%)
		fn3	708..796	CDD:394996	16/89 (18%)
		fn3	902..978	CDD:394996	24/77 (31%)
		fn3	1013..1092	CDD:394996	18/82 (22%)
		PTP_tm	1127..1247	CDD:465889	47/143 (33%)
		R3-PTPc	1358..1579	CDD:350396	125/228 (55%)
PTPRB	XP_006719591.1	beta-trefoil_Ricin_PTPRB-like	18..134	CDD:467787
		fn3	255..316	CDD:394996
		fn3	331..407	CDD:394996
		FN3	422..488	CDD:473895
		FN3	507..582	CDD:238020	16/61 (26%)
		fn3	596..672	CDD:394996	25/93 (27%)
		fn3	687..765	CDD:394996	22/84 (26%)
		fn3	774..847	CDD:394996	16/75 (21%)
		fn3	862..938	CDD:394996	10/75 (13%)
		fn3	950..1026	CDD:394996	9/75 (12%)
		fn3	1039..1112	CDD:394996	29/83 (35%)
		FN3	1093..1508	CDD:442628	98/450 (22%)
		fn3	1126..1199	CDD:394996	16/78 (21%)
		fn3	1393..1466	CDD:394996	20/75 (27%)
		fn3	1480..1562	CDD:394996	25/93 (27%)
		fn3	1574..1653	CDD:394996	19/87 (22%)
		PTP_tm	1691..1828	CDD:465889	47/143 (33%)
		R-PTPc-B	1949..2176	CDD:350465	126/229 (55%)