DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and PTPRB

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:XP_006719591.1 Gene:PTPRB / 5787 HGNCID:9665 Length:2230 Species:Homo sapiens


Alignment Length:1809 Identity:505/1809 - (27%)
Similarity:763/1809 - (42%) Gaps:413/1809 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 PPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLT----WTVNIT------- 148
            ||......|.|:  |..| .||.||.|..     |:   ..||.::|.    :.|.::       
Human   531 PPGNVDSYNITL--SHKG-TIKESRVLAP-----WI---TETHFKELVPGRLYQVTVSCVSGELS 584

  Fly   149 --------TAPDPPANLSVQLRS-SKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSL---- 200
                    |.||..|||...... .:|..::|.|| :|.:..:||       |.|..|..|    
Human   585 AQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPP-AGDWEQYRI-------LLFNDSVVLLNIT 641

  Fly   201 EGNETLQ--LSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFI--------VWFR 255
            .|.|..|  :....|.||..|:|:          |...|.|........|:.:        |...
Human   642 VGKEETQYVMDDTGLVPGRQYEVE----------VIVESGNLKNSERCQGRTVPLAVLQLRVKHA 696

  Fly   256 NETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQ 320
            |||:|.::||.  |...:..|.:|:...|.:.....:.::.:     :..|..|||||:|..:|.
Human   697 NETSLSIMWQT--PVAEWEKYIISLADRDLLLIHKSLSKDAK-----EFTFTDLVPGRKYMATVT 754

  Fly   321 TVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVML------- 378
            ::|.|..:|.....|  |||.:|.::.......|||.| ..|...:...||  |||:|       
Human   755 SISGDLKNSSSVKGR--TVPAQVTDLHVANQGMTSSLF-TNWTQAQGDVEF--YQVLLIHENVVI 814

  Fly   379 -------STSRRIFN------------------------------VPRAANG----DSVYFDYPD 402
                   .|||..|:                              ||.:.:|    :|...||..
Human   815 KNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLS 879

  Fly   403 I---------------------------------------LEPGRTYEVVV-------------- 414
            :                                       |.|||.|.|.:              
Human   880 VSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQ 944

  Fly   415 -KTIADNVN---------------SW-PASG-----EVTLR------------------------ 433
             :|:.|.|.               || .|:|     |||::                        
Human   945 ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLV 1009

  Fly   434 ---------------------------PRPVRSLGGFLDDRSNA-LHISWEPAETGRQDSYRISY 470
                                       |.||:.|  .|.:||.. ||::|..| .|..|.|.|..
Human  1010 PGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDL--TLRNRSTEDLHVTWSGA-NGDVDQYEIQL 1071

  Fly   471 HEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAA 535
              ..|..:|..||      .:....|||...||..||:|.|.|..:|..|..:|. |..:|.|:|
Human  1072 --LFNDMKVFPPF------HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF-IEGFTVPSA 1127

  Fly   536 PLIQELRSIDQG----LMLSWR---SDVNSRQDRYEVHYQRNGTR-EERTMATNETSLTIHYLHP 592
              ::.:.....|    |.::|.   .||    |.|.|...|:..: :.:|:..:....|.|.|..
Human  1128 --VKNIHISPNGATDSLTVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEA 1186

  Fly   593 GSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNL-VVLHWQAPEGSD-------FS 649
            |..|::.:.::|..::::.:...:.| |...|.:.....:::. :::.||...|..       .:
Human  1187 GEQYQIMIASVSGSLKNQINVVGRTV-PASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1250

  Fly   650 EYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSN 714
            |..:..|..:.|      ....:.:.:|:..|::|.:|:.|||.|:.|........|:|......
Human  1251 ENGILLRNTSEP------ATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1309

  Fly   715 VVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDE--EDRVEFKNVTQLEDLSSPSVRIPIEDLSPG 777
            .:....:|:|:..|...:|.:.:|.:..:..|.  ::|.:...:.|         ....::|..|
Human  1310 RITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQ---------SFSFQNLLQG 1365

  Fly   778 RQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT----LSYTPTPADSTR 838
            |.|:. |..:.:|..|..:.:..||:|        |:..|.:|.:...|    .:::|...|   
Human  1366 RMYKM-VIVTHSGELSNESFIFGRTVP--------ASVSHLRGSNRNTTDSLWFNWSPASGD--- 1418

  Fly   839 FDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPI 903
            ||.|...:.:|....||...:....:..|.||.||:.|.:.|.|.||.::: .|....|..|.|.
Human  1419 FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSN-KVTAESRTAPSPP 1482

  Fly   904 SDLKAIQVAAREITLHWTAPAG--EYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYT 966
            |.:....:|...:.:.|..|..  :|.|||||:|..|........|..|:....:.||||..:|.
Human  1483 SLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQ 1547

  Fly   967 FTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEP 1031
            |.|...||....|            .|.||..|.:|   .|.|:............:...| :.|
Human  1548 FNVKTVSGDSWKT------------YSKPIFGSVRT---KPDKIQNLHCRPQNSTAIACSW-IPP 1596

  Fly  1032 AEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGK----IDGLVPGNHYIFRIQAKSALGYGAE 1092
               ....|.:.|.|:.    .|....||.....:.|    |..|||...|:..|:.:|| |..:|
Human  1597 ---DSDFDGYSIECRK----MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA-GMTSE 1653

  Fly  1093 REHIQTMPIL---APPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNA 1154
            .....|:.::   .||.|...|...:|..:.|:|..:....:||:.:|.|:.:|:::.|..|.:.
Human  1654 VVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE 1718

  Fly  1155 SGLE----MPSWQD------VQAY-TVWLPYQAIEPYNPFLTSNGSRKS---SLEAEHFTIGTAN 1205
            ...|    :||:.:      ::.| |.:...:..|  ||    |.:.||   .|.||..::| ..
Human  1719 LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAE--NP----NSNSKSFNIKLGAEMESLG-GK 1776

  Fly  1206 CDKHQAGYCNGPLRAGTTYRIKIRAFT---DED--KFT-----DTVYSSPITTERSDTVIVAATV 1260
            ||..|..:|:|||:..|.|||.|||||   |||  :||     ||.:|.|||||..........|
Human  1777 CDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV 1841

  Fly  1261 SA-VLLVAMVLVVV---YCQHRCQ--LIRRASKLARMQDELAAL-----PEGYITPNRPVHVKDF 1314
            || :.|:.|::.||   .|:.:..  ..|.:::|:..:|...::     .:|....:.|:.:..|
Human  1842 SAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQF 1906

  Fly  1315 SEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDD 1379
            ..|:..:.|||::..|:|:||||.|||:|:|..|.||.||.|||:.||||||.:|.||..||||.
Human  1907 EGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDP 1971

  Fly  1380 GSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV 1444
            .||||||:|:||:|..||:|||||||..|:::||:|.||.|...|||:|:|.||||.|||.|||.
Human  1972 CSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA 2036

  Fly  1445 DRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC------ESRIMRHFHFTTWPDFGVPEPPQSL 1503
            |:.:::|||:.:|::.::...:|:|.||.:   |      ..|::||||:|.|||.||||..|||
Human  2037 DQDSLYYGDLILQMLSESVLPEWTIREFKI---CGEEQLDAHRLIRHFHYTVWPDHGVPETTQSL 2098

  Fly  1504 VRFVRAFRDVIGTD--MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVF 1566
            ::|||..||.|...  ..|.:|||||||||:|||||||||||.:...|.|||:|.|..:|..||.
Human  2099 IQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2163

  Fly  1567 MVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMG 1620
            |||||.|||.:|||:..||..:        :|.:.....:..||....|:...|
Human  2164 MVQTECQYVYLHQCVRDVLRAR--------KLRSEQENPLFPIYENVNPEYHRG 2209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 27/97 (28%)
fn3 247..328 CDD:278470 22/88 (25%)
fn3 343..417 CDD:278470 28/175 (16%)
fn3 443..525 CDD:278470 27/82 (33%)
FN3 548..611 CDD:238020 15/66 (23%)
FN3 620..706 CDD:238020 17/93 (18%)
fn3 708..796 CDD:278470 16/89 (18%)
fn3 824..886 CDD:278470 18/65 (28%)
fn3 902..978 CDD:278470 24/77 (31%)
fn3 1013..1092 CDD:278470 18/82 (22%)
UP_III_II 1106..>1248 CDD:297589 53/165 (32%)
PTPc 1329..1582 CDD:214550 146/260 (56%)
PTPc 1355..1582 CDD:238006 130/234 (56%)
PTPRBXP_006719591.1 RICIN <22..94 CDD:238092
fn3 255..319 CDD:278470
fn3 331..407 CDD:278470
fn3 422..488 CDD:278470
FN3 507..582 CDD:238020 16/61 (26%)
fn3 596..672 CDD:278470 25/93 (27%)
fn3 687..765 CDD:278470 22/84 (26%)
fn3 774..847 CDD:278470 16/75 (21%)
fn3 862..938 CDD:278470 10/75 (13%)
fn3 950..1026 CDD:278470 9/75 (12%)
fn3 1039..1112 CDD:278470 29/83 (35%)
fn3 1126..1199 CDD:278470 16/78 (21%)
fn3 1216..1294 CDD:278470 16/83 (19%)
fn3 1305..1378 CDD:278470 13/82 (16%)
fn3 1394..1466 CDD:278470 20/74 (27%)
fn3 1480..1562 CDD:278470 25/93 (27%)
fn3 1574..1649 CDD:278470 18/83 (22%)
PTPc 1920..2178 CDD:214550 145/260 (56%)
PTPc 1947..2178 CDD:238006 129/233 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 285 1.000 Domainoid score I1621
eggNOG 1 0.900 - - E2759_KOG0791
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 556 1.000 Inparanoid score I1112
Isobase 1 0.950 - 0 Normalized mean entropy S5167
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 1 1.000 - - FOG0001181
OrthoInspector 1 1.000 - - otm40832
orthoMCL 1 0.900 - - OOG6_106915
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 1 1.000 - - X4185
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.710

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