Protein Alignment Ptp4E and PTPN13

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Alignment Length: 1636
• Identity: 347/1636 - (21%)
• Similarity: 544/1636 - (33%)
• Gaps: 596/1636 - (36%)

  Fly   135 STHREQLTWTVNITTAPDPPANLSVQLRSSKSAFI------TWRPPGSGRYSGFRIRVLGLTDLP 193
            ::|....||..:...:|.|..   :...:.|..|.      |.:|              |::|:
Human  1266 ASHLGDQTWQESQHGSPSPSV---ISKATEKETFTDSNQSKTKKP--------------GISDV- 1312

  Fly   194 FERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTS-----RNFTTKPNTPGKF--I 251
              ..||..|:..:.    |.|...|...|  :..|...|...||     :.|::.|..||..  :
Human  1313 --TDYSDRGDSDMD----EATYSSSQDHQ--TPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEV 1369

  Fly   252 VWFRNETTL----LVLWQPPFPAGIYTH------YRVSITPDDAIQSVLYVEREGEPPGPAQAAF 306
            ...:|:.:|    .||:.   ..|:.|.      |..::.|..|.:|...:.:     |....|.
Human  1370 ELAKNDNSLGISVTVLFD---KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK-----GDRVLAV 1426

  Fly   307 KGL-VPGREYNISVQTVSED--------ETSSVPTTARYLTV---------------PERVLNVT 347
            .|: :.|..:..:|:|:...        |....||:..::.|               ||:|...|
Human  1427 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1491

  Fly   348 FDEAYTTSSSFRVRWEPPRTYSEFDAYQVML---------STSRRIFNVPRAANGDSVYFDYPDI 403
            ..:.|    ||         .:|.:.::|.|         |.||....:|...|...|....
Human  1492 QVKDY----SF---------VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKK--- 1540

  Fly   404 LEPGRTYEVVVKTIADNVNSWPAS-------GEVTLRPRPVRSLGGFLDDRSNALHISWEPAETG 461
            |.||:                ||:       |:|.|:.... ||.|
Human  1541 LFPGQ----------------PAAESGKIDVGDVILKVNGA-SLKG------------------- 1569

  Fly   462 RQDSYRISYHEQTNASEVPAPF--------PVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSK 518
                  :|..|..:|....||.        |.....:|.|.|              |..:|:.::
Human  1570 ------LSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTAL--------------LTPLQSPAQ 1614

  Fly   519 GVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVN-------SRQDRYEVHYQRNGTREER 576
            .:.:::.|   .::|:.  :::..|.|:..|    ||.:       ||:|.|
Human  1615 VLPNSSKD---SSQPSC--VEQSTSSDENEM----SDKSKKQCKSPSRRDSY------------- 1657

  Fly   577 TMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQ 641
                :::|        |||.:..|.|                    |.|::..|
Human  1658 ----SDSS--------GSGEDDLVTA--------------------PANISNST----------- 1679

  Fly   642 APEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVT 706
                                |.  |.||
Human  1680 --------------------WS--SALH------------------------------------- 1685

  Fly   707 MPPQPVSNVVPLVDSRNLTLEWPRPDGHVD-FYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIP 770
               |.:||:|....|.:     ..|....| ..|:.::|....::.||::       |:||...|
Human  1686 ---QTLSNMVSQAQSHH-----EAPKSQEDTICTMFYYPQKIPNKPEFED-------SNPSPLPP 1735

  Fly   771 IEDLSPGRQY--RFEVQASSNGIRSGTTHLSTRT-----MPL------------IQSDVFIANAG 816
              |::||:.|  :.|..:||:..:....|:|..|     .||            ::.::.|....
Human  1736 --DMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIK 1798

  Fly   817 HEQGQDETITLSYTPTPADSTRFDIY-------------RFSMGDPTIKDKEKLANDTERKLSFS 868
            .|:|     :|.:|.|..:. |...|             |...||..||     .|||:    .:
Human  1799 SEKG-----SLGFTVTKGNQ-RIGCYVHDVIQDPAKSDGRLKPGDRLIK-----VNDTD----VT 1848

  Fly   869 GLTPGKLYNV------TVWTVSGGVASLPVQRLYRL-HPLPISDLKAIQVAAREITLHWTAPAGE 926
            .:|.....|:      ||..|.|.|..||  |:..| |.||            :|||
Human  1849 NMTHTDAVNLLRAASKTVRLVIGRVLELP--RIPMLPHLLP------------DITL-------- 1891

  Fly   927 YTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMR 991
                                  |.|.|.....|...|:..:.||.         .:|::    .|
Human  1892 ----------------------TCNKEELGFSLCGGHDSLYQVVY---------ISDIN----PR 1921

  Fly   992 SSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSS 1056
            |.|.|..:.|.|..    :.|......|                      .:|.:..:.|.|:|.
Human  1922 SVAAIEGNLQLLDV----IHYVNGVSTQ----------------------GMTLEEVNRALDMSL 1960

  Fly  1057 YEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSS 1121
            ....:.||:..:. :||.:........||..|.|:......:.|.|.|.....:|...|::
Human  1961 PSLVLKATRNDLP-VVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEIN---- 2020

  Fly  1122 TIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIE----PYN- 1181
              |||:.:|..|       :|.|       |.:..|.:|...        .|.|:..    |.|
Human  2021 --EISYPKGKCS-------TYQI-------KGSPNLTLPKGS--------FPNQSSNYSKCPNNS 2061

  Fly  1182 -PFLTSNGSRKSSLEAEHFTIGTANCDK---------HQAGYCNGPLRAGTTYRIKIRAFTDEDK 1236
             .::..:.....|.|||.........|:         :.|||..||   ||   :|:.....|::
Human  2062 ESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGP---GT---LKMNGKLSEER 2120

  Fly  1237 FTDT-VYSSPIT---TERSDTVIVAATVSAVLLVAMVLVVVYCQHRC-QLIRRASKLARMQ---- 1292
            ..|| ...||:.   ||       |..::.            |:..| :.::..|.:.:.|
Human  2121 TEDTDCDGSPLPEYFTE-------ATKMNG------------CEEYCEEKVKSESLIQKPQEKKT 2166

  Fly  1293 -------------------------------DELAALPEGYITPNRPVHVKDFSEHYRIMSADSD 1326
                                           ||||.||...:.|:......:.....|::....|
Human  2167 DDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLD 2231

  Fly  1327 FRF-SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMP 1390
            ... |:|.|.|:.:.....|.......||.|||:.||||||.:|.   |:.|:.|  ||||:::.
Human  2232 QGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRV---PLGDEGG--YINASFIK 2291

  Fly  1391 GHNSPREF--IVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP--VDRVAMFY 1451
            ......||  |..||||.:|..:||:|.||..|..|.|:|:..|..:.||.:|||  :.:..|..
Human  2292 IPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVS 2356

  Fly  1452 GDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRA 1509
            ..:::.|:     ....:..|:|.       :..|.|.:.|.:||.|||...|..|..|:.|:..
Human  2357 NRLRLALV-----RMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISY 2416

  Fly  1510 FRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQY 1574
            .|.:..:.  |||.|||||:|||||.|.:|.:|..|.:....||..:|..||.:|..|||||.||
Human  2417 MRHIHRSG--PIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQY 2479

  Fly  1575 VCIHQCLLAVL 1585
            :..:|.:|.||
Human  2480 IFCYQVILYVL 2490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	45/230 (20%)
		fn3	247..328	CDD:394996	19/101 (19%)
		FN3	319..>749	CDD:442628	77/484 (16%)
		fn3	708..796	CDD:394996	22/90 (24%)
		fn3	902..978	CDD:394996	11/75 (15%)
		fn3	1013..1092	CDD:394996	13/78 (17%)
		PTP_tm	1127..1247	CDD:465889	29/135 (21%)
		R3-PTPc	1358..1579	CDD:350396	85/231 (37%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189	26/126 (21%)
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254	16/98 (16%)
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181	24/133 (18%)
		PDZ4_PTPN13-like	1789..1873	CDD:467182	22/98 (22%)
		PDZ5_PTPN13-like	1884..1970	CDD:467183	28/166 (17%)
		PTPc-N13	2257..2490	CDD:350445	91/244 (37%)