DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and PTPN11

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens


Alignment Length:684 Identity:167/684 - (24%)
Similarity:254/684 - (37%) Gaps:224/684 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1014 QPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYI 1078
            :||...||:.|..     ..::|.:.:.:|  ||..|..|:                        
Human    32 RPSKSNPGDFTLS-----VRRNGAVTHIKI--QNTGDYYDL------------------------ 65

  Fly  1079 FRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYT 1143
                      ||.|:     ...||..|.                       |:...||.::.  
Human    66 ----------YGGEK-----FATLAELVQ-----------------------YYMEHHGQLKE-- 90

  Fly  1144 IIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYN--------------PFLTSNGSRKSSL 1194
                    ||...:|:.           .|....:|.:              ..||..|...|.|
Human    91 --------KNGDVIELK-----------YPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFL 136

  Fly  1195 EAE------HFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDE-------DKFTDTV----- 1241
            ..|      .|.:.....|  ..|..|......|...|:.:....:       |..||.|     
Human   137 VRESQSHPGDFVLSVRTGD--DKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKK 199

  Fly  1242 ------------YSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDE 1294
                        ...|:.|.|    |.||.:.:                  .:|..||||...|:
Human   200 NPMVETLGTVLQLKQPLNTTR----INAAEIES------------------RVRELSKLAETTDK 242

  Fly  1295 LAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSF------ANLPCN 1353
               :.:|                           |.||||.|    :.|.|..      .....|
Human   243 ---VKQG---------------------------FWEEFETL----QQQECKLLYSRKEGQRQEN 273

  Fly  1354 RPKNRFTNILPYDHSRFKLQPVDDDDG-SDYINAN-YMP------GHNSPRE-FIVTQGPLHSTR 1409
            :.|||:.||||:||:|..|...|.::. ||||||| .||      .::.|:: :|.|||.|.:|.
Human   274 KNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTV 338

  Fly  1410 EEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV 1474
            .:||||.::.|||.|||.|:..|:|:.||.:|||.:.....||.::|:.:.::..||:::.|..:
Human   339 NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKL 403

  Fly  1475 SR--------NCESRIMRHFHFTTWPDFGVPEPPQSLVRF---VRAFRDVIGTDMRPIIVHCSAG 1528
            |:        |.| |.:..:||.||||.|||..|..::.|   |...::.| .|..|::||||||
Human   404 SKVGQALLQGNTE-RTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI-MDAGPVVVHCSAG 466

  Fly  1529 VGRSGTFIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEH 1590
            :||:||||.:|.::..|.:...   :|:...:..:|.:|..|||||.||..|:..:...:|..:.
Human   467 IGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR 531

  Fly  1591 LLADSLELHANDGYEVTKIYLERQPQTKMGTLPI 1624
            .:.:. :.....|:|.|.|......||.....|:
Human   532 RIEEE-QKSKRKGHEYTNIKYSLADQTSGDQSPL 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628
fn3 247..328 CDD:394996
FN3 319..>749 CDD:442628
fn3 708..796 CDD:394996
fn3 902..978 CDD:394996
fn3 1013..1092 CDD:394996 13/77 (17%)
PTP_tm 1127..1247 CDD:465889 25/163 (15%)
R3-PTPc 1358..1579 CDD:350396 94/243 (39%)
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203 24/160 (15%)
SH2_C-SH2_SHP_like 111..218 CDD:198185 17/108 (16%)
PTPc-N11 272..528 CDD:350453 97/257 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575 3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

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