DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and PTPN7

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_011508121.1	Gene:	PTPN7 / 5778	HGNCID:	9659	Length:	511	Species:	Homo sapiens

Alignment Length:	353	Identity:	92/353 - (26%)
Similarity:	146/353 - (41%)	Gaps:	92/353 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1278 RCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRD 1342
            |..|.|:.....::::|...:|..:::|                            |:|
Human   189 RWALQRQPPSPKQLEEEFLKIPSNFVSP----------------------------EDL------ 219

  Fly  1343 QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPRE-FIVTQGPLH 1406
                  ::|.:..|:|:..|||...||..|......:..|||||||:.|::...: :|.||||:.
Human   220 ------DIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMP 278

  Fly  1407 STREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISE 1471
            :|..:||.|.|:.....|||||: ..:|:|||..|||.:...  ||..::::.......::::.:
Human   279 NTVSDFWEMVWQEEVSLIVMLTQ-LREGKEKCVHYWPTEEET--YGPFQIRIQDMKECPEYTVRQ 340

  Fly  1472 FMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR--PIIVHCSAGVGRSGT 1534
            ..:....|.|.::|..|:.|||...||....|:|.|....:...|...  ||:||||||:||:|.
Human   341 LTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGC 405

  Fly  1535 FIALDRILQHIHKSDYVDIFGIVFAMRKERVF--------------------------------- 1566
            |||.....|.:.....|||.|||..:|.:|:.
Human   406 FIATRIGCQQLKARGEVDILGIVCQLRLDRLLERRKLEAQEYSWPDPRLQRSGFVPGAEWIKEDQ 470

  Fly  1567 -------------MVQTEQQYVCIHQCL 1581
                         |:||.:||..:|..|
Human   471 VSTWGITPQHVGGMIQTAEQYQFLHHTL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020
		fn3	708..796	CDD:278470
		fn3	824..886	CDD:278470
		fn3	902..978	CDD:278470
		fn3	1013..1092	CDD:278470
		UP_III_II	1106..>1248	CDD:297589
		PTPc	1329..1582	CDD:214550	86/302 (28%)
		PTPc	1355..1582	CDD:238006	83/276 (30%)
PTPN7	XP_011508121.1	PTPc	201..499	CDD:214550	89/341 (26%)
PTPN7	XP_011508121.1	PTPc	227..499	CDD:238006	83/275 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910