DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and COL20A1

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_011527239.1	Gene:	COL20A1 / 57642	HGNCID:	14670	Length:	1429	Species:	Homo sapiens

Alignment Length:	1014	Identity:	210/1014 - (20%)
Similarity:	353/1014 - (34%)	Gaps:	278/1014 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 RYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFD 399
            |...:||..|.:.:.|:..:...:.|:.:|....||   .:|:|:|     ..|:|..|.
Human    33 RLAVLPEDRLQMKWRESEGSGLGYLVQVKPMAGDSE---QEVILTT-----KTPKATVGG----- 84

  Fly   400 YPDILEPGRTY------------------EVVVKTI----ADNVNSWP-ASGEVTLRPRPVRSLG 441
                |.|.:.|                  |.|::.:    .|..:..| .||    .|.|..|..
Human    85 ----LSPSKGYTLQIFELTGSGRFLLARREFVIEDLKSSSLDRSSQRPLGSG----APEPTPSHT 141

  Fly   442 GFLD-DRSNALHISWEPAETGR---------------------QDSYRI--SYHEQTN--ASEVP 480
            |..| ::::...:::.|::..|                     ..|:.|  |:.:|..  .:.|.
Human   142 GSPDPEQASEPQVAFTPSQDPRTPAGPQFRCLPPVPADMVFLVDGSWSIGHSHFQQVKDFLASVI 206

  Fly   481 APFPVAAESQITTNLTEYT--------LDSLLAGRRYLIAVQ-------------ALSKGVASNA 524
            |||.:..: ::...||:|:        |:||....:.|.||:             ||:..:..|
Human   207 APFEIGPD-KVQVGLTQYSGDAQTEWDLNSLSTKEQVLAAVRRLRYKGGNTFTGLALTHVLGQN- 269

  Fly   525 SDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQD--------------RYEVHYQRNGTREE 575
                  .:|||.|..|...:   ::|.  :|..|:.|              .:.|..:.....|.
Human   270 ------LQPAAGLRPEAAKV---VILV--TDGKSQDDVHTAARVLKDLGVNVFAVGVKNADEAEL 323

  Fly   576 RTMATNETSLTIH----YLHPGSGYEVKVHAISHGV-----RSEPHSYFQAVFPKP-PQNLTLQT 630
            |.:|:....:|:|    :|..|:...:....|...:     |..|.:...|:...| |.:|.|..
Human   324 RLLASPPRDITVHSVLDFLQLGALAGLLSRLICQRLQGGSPRQGPAAAAPALDTLPAPTSLVLSQ 388

  Fly   631 VHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQR---ISG------LHENEARIKDMHYGERYLV 686
            |.::.:.|.| .|......:|::.:|.......|   :.|      ||...:|.:       |||
Human   389 VTSSSIRLSW-TPAPRHPLKYLIVWRASRGGTPREVVVEGPAASTELHNLASRTE-------YLV 445

  Fly   687 QVNTVSFGVESPHPLELNVTMP-PQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDR 750
            .|..:..|........|..|.| |.|.:..:..|..|.:.|.| :|......|.::..|...:..
Human   446 SVFPIYEGGVGEGLRGLVTTAPLPPPRALTLAAVTPRTVHLTW-QPSAGATHYLVRCSPASPKGE 509

  Fly   751 VEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQ-------ASSNGIRSGTTHLSTRTMPLIQS 808
            .|.:.|    .:..|.|.  ::.|.|||.|...||       :.:.|||:.|..|:. ...|..|
Human   510 EEEREV----QVGRPEVL--LDGLEPGRDYEVSVQSLRGPEGSEARGIRARTPTLAP-PRHLGFS 567

  Fly   809 DVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPG 873
            ||     .|:..:   :.....|.|....|. .|..|.|..        :..||...:.:..|.|
Human   568 DV-----SHDAAR---VFWEGAPRPVRLVRV-TYVSSEGGH--------SGQTEAPGNATSATLG 615

  Fly   874 KLYNVTVWTV-------SGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHW--TAPAGEYTD 929
            .|.:.|.:||       .||.::|..:...:..|.| |.|...::....:.|.|  .||:|...
Human   616 PLSSSTTYTVRVTCLYPGGGSSTLTGRVTTKKAPSP-SQLSMTELPGDAVQLAWVAAAPSGVLV- 678

  Fly   930 FELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSA 994
            :::.:....|         .|..||::.|       .....|..|..:.|:: ||::....|..|
Human   679 YQITWTPLGE---------GKAHEISVPG-------NLGTAVLPGLGRHTEY-DVTILAYYRDGA 726

  Fly   995 ---PISASYQTLT---APPGKV-------DYFQPSDVQP-GEVTFEW-SLEPAEQHGPIDYFRIT 1044
               |:|..|...|   :||..:       |..|.|...| |.|...| :..||...||
Human   727 RSDPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWTPPLGRVLHYWLTYAPASGLGP------- 784

  Fly  1045 CQNADDAADVSSYEFPVN------ATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILA 1103
                :.:..|......|.      ||:.::  ||...:...|.:|.||.|..|      ..|.|.
Human   785 ----EKSVSVPGARSHVTLPDLQAATKYRV--LVSAIYAAGRSEAVSATGQTA------ACPALR 837

  Fly  1104 PPVPEPSVTPLEVSRTSSTIEISFRQGYFS--------NAHGMVRSYTIIIAEDVGKNASGL--- 1157
               |:.|:...::....|.:|    :.|.|        :|.|...::|:.....:.:..|.:
Human   838 ---PDGSLPGFDLMVAFSLVE----KAYASIRGVAMEPSAFGGTPTFTLFKDAQLTRRVSDVYPA 895

  Fly  1158 EMPSWQDV------------QAYTVWLPYQAIEPYNPFL 1184
            .:|....:            :|:.:|  ....|.:.|.|
Human   896 PLPPEHTIVFLVRLLPETPREAFALW--QMTAEDFQPLL 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470	17/91 (19%)
		fn3	443..525	CDD:278470	23/128 (18%)
		FN3	548..611	CDD:238020	14/85 (16%)
		FN3	620..706	CDD:238020	21/95 (22%)
		fn3	708..796	CDD:278470	24/95 (25%)
		fn3	824..886	CDD:278470	14/68 (21%)
		fn3	902..978	CDD:278470	15/77 (19%)
		fn3	1013..1092	CDD:278470	21/86 (24%)
		UP_III_II	1106..>1248	CDD:297589	16/102 (16%)
		PTPc	1329..1582	CDD:214550
		PTPc	1355..1582	CDD:238006
COL20A1	XP_011527239.1	fn3	39..102	CDD:278470	16/79 (20%)
		vWA_collagen_alphaI-XII-like	178..341	CDD:238759	35/175 (20%)
		fn3	379..457	CDD:278470	20/85 (24%)
		fn3	469..542	CDD:278470	20/79 (25%)
		FN3	560..645	CDD:238020	22/102 (22%)
		fn3	649..725	CDD:278470	20/94 (21%)
		fn3	743..822	CDD:278470	20/91 (22%)
		LamG	844..1038	CDD:304605	14/95 (15%)
		Collagen	1133..1219	CDD:189968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000