Protein Alignment Ptp4E and ephb6

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_005173575.1
• Gene: ephb6 / 572411
• ZFINID: ZDB-GENE-100922-51
• Length: 1003
• Species: Danio rerio
• Alignment Length: 1203
• Identity: 229/1203 - (19%)
• Similarity: 382/1203 - (31%)
• Gaps: 402/1203 - (33%)

  Fly    63 IFLA-----QHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALP 122
            |||:     ||::|.:::: :..:.|.|...:..  .|..|:.|.:.   ..|.|:.::
Zfish     6 IFLSVSLVVQHSSAEEVML-LDTSESTAELGWTT--YPDTGWDEVSV---LDDKGRLMR------ 58

  Fly   123 GTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVL 187
                .|.:...|...|.|..|.          |...:..:|:...|:|.|         |.:|
Zfish    59 ----TFEVCNVNQNPRLQDNWL----------ATPFLYRQSAPRIFVTLR---------FSVR-- 98

  Fly   188 GLTDLPFERSYSLEGNETLQL------SAKELTPGGSYQVQAYSVYQG--KESVAYTSRNFT-TK 243
               |....||.|....|||.|      |.:||....:.:..:....:|  |.......::|: .:
Zfish    99 ---DCASLRSPSPTCRETLTLYYKQADSQRELERTWAAEASSGETREGWVKIDTIAADKSFSRVE 160

  Fly   244 PNTPGKFIVWFRNETTLLV-----LWQPPFPAGIYTHYRVSITPDDAIQSVLYVE---REGEPPG 300
            |:.|.:    :::|....:     .:.|....|    :.::|....|..|::.|.   |.    .
Zfish   161 PSLPHQ----YKSENARRINVKTRSFAPLTRKG----FVLAIVDSGACVSLMGVSIFYRR----C 213

  Fly   301 PAQAAFKGLVPGREYNISVQTVSEDE-TSSVPTTARYL--------TVPERVLNV---------- 346
            ||.:.|....|.        |.|..| ||.||.|...:        |.|....|.
Zfish   214 PATSRFLAFYPA--------TPSGAEPTSLVPVTGTCVPHSQSQGGTAPRMHCNTEGEWLVPVGG 270

  Fly   347 -TFDEAYTTSSSFRVRWEPPRTYS--------EFDAYQVMLSTSRRIFNVPRAANGDSV------ 396
             |.|..|          ||....|        .:.|....:|.:....|...::.|..|
Zfish   271 CTCDAGY----------EPNHNGSACLVCPIGSYKAVAGSVSCTECPANSRTSSEGAKVCECRSG 325

  Fly   397 YFDYPDILEPGRTYEVVVKTIADNVNSW---PASGEVTLRPRPVRSLGGFLDDRSNALHISWE-- 456
            |:..|   ....|........|....||   .:.|.|:||.||...:||..|        .|.
Zfish   326 YYRAP---ADANTTACTSSPSAPLALSWEYESSEGGVSLRWRPPADMGGRTD--------VWYGV 379

  Fly   457 -----PAETGRQDSY------RISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYL 510
                 |:.|....|.      .::|                :.||.....|..||.:||....||
Zfish   380 VCRICPSATSTPPSMCSWCGETVTY----------------SPSQNGLKQTRVTLKNLLTRVTYL 428

  Fly   511 IAVQALSKGVA--------SNASDITRYTRPA-APLIQELRSIDQGLMLSWRSDVNSRQD--RYE 564
            |.|||:::..|        ::.:..|..:.|: .|::.:|..:...:.|||........|  .|:
Zfish   429 IQVQAMNEVSALSPFPPQFASINFTTSQSVPSEVPMLHQLSRVQDSITLSWPQPDRPNGDILEYQ 493

  Fly   565 VHYQRNGTREER--TMATNETSLTIHYLHPGSGYEVKVHAIS-HGVRSEPHSYFQAVFPKPPQNL 626
            :.|...|:.|:.  :|.:...::|:..|.|||.|..::.|.: .|.....|:.:.:......|:.
Zfish   494 LRYYDKGSDEDSALSMYSETNTVTVTGLIPGSIYAFQIRARNERGFGPYSHTIYFSTLASEGQSK 558

  Fly   627 TLQTVHTNLVVLHWQAPEGSDF--------SEYVVRYRTDASPW-QRISGLHENEARIKDMHYGE 682
            .:|   ..|.::......|:.|        ..:|.|.:...||: .|:.....|..       |.
Zfish   559 QIQ---NRLPLMIGSVMGGAAFLLVVIAIIIVFVFRSKRRESPYSDRLQRYISNRG-------GV 613

  Fly   683 RYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWP--------------RPDG 733
            :|.|..:|..              .|.:.|......:|..:|.:|..              ||.|
Zfish   614 KYYVDPSTYE--------------DPSEAVKEFAREIDPAHLKIEEVIGAAQFGEVSRGRYRPIG 664

  Fly   734 H----VDFYTLKWWPTDEEDRV-----------EFKNVTQLEDL--SSPSVRIPIEDLSPGRQYR 781
            .    |...||:|..|:.|..|           :..||.:||.:  .:|..||..|.:..|....
Zfish   665 RREALVAVKTLRWGVTEREKNVFLSEAGVLGQFDHPNVLKLEGVITRTPPERIITEFMENGPLDA 729

  Fly   782 F-----------EVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPAD 835
            |           ::.....|:.:|..:||.|.  .:..|:...|.
Zfish   730 FLRENEDQFSVLQLVGMVRGVGAGMRYLSERN--FVHRDLAARNV-------------------- 772

  Fly   836 STRFDIYRFSMGDPTIKDKEKLAN-DTERKLSFSGLT---PGKLYNVTVWTVSGGVASLPVQRLY 896
                                 |.| :...|:|..||:   .|..:|:..:|.|.| :.:||:
Zfish   773 ---------------------LVNSNLVCKVSDFGLSRLMRGLDHNMPTYTASLG-SKIPVR--- 812

  Fly   897 RLHPLPISDLKAIQVAAREITLHWTAP-AGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLR 960
                                   |||| |.::..|.   .::|..:..:|.     .|:...|.|
Zfish   813 -----------------------WTAPEAFQHRKFS---SASDVWSFGILM-----WEVMSYGER 846

  Fly   961 PYHNYTFTVVVRSGSIQ-----------------------------GTDFADVSVSTLMRSSAPI 996
            ||.:.:...|:::...|                             |.|....|:..|:|..|.:
Zfish   847 PYWDMSNQEVMKAVVDQYRLPAPNGCPPALHSLMLQCWQADRQDRPGFDSLLSSLDRLIRHPASL 911

  Fly   997 SASYQTLTAP---PGKVDYFQPSDVQPGEVTFEW-----------SLEPAEQHGPIDYFRITCQN 1047
            .|.:...|.|   |      .|:|:.......:|           :.|.|:.|.......:|.|:
Zfish   912 KAEHSRPTQPLLSP------TPTDLSSVNTVGDWLTVLKMDRYKDAFERAQYHSLESVSMLTMQD 970

  Fly  1048 ADDAADV-----------SSYEFPVNATQGKID 1069
            . .|..|           ::.:...:.|||.::
Zfish   971 V-QALGVNLLGHQRKIVNAAKQLRTHLTQGHVE 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	52/257 (20%)
		fn3	247..328	CDD:394996	16/89 (18%)
		FN3	319..>749	CDD:442628	106/520 (20%)
		fn3	708..796	CDD:394996	27/129 (21%)
		fn3	902..978	CDD:394996	15/105 (14%)
		fn3	1013..1092	CDD:394996	13/79 (16%)
		PTP_tm	1127..1247	CDD:465889
		R3-PTPc	1358..1579	CDD:350396
ephb6	XP_005173575.1	Ephrin_lbd	22..213	CDD:460198	43/242 (18%)
		Ephrin_rec_like	<286..318	CDD:429604	4/31 (13%)
		FN3	<336..>552	CDD:442628	53/239 (22%)
		FN3	473..550	CDD:238020	18/76 (24%)
		EphA2_TM	568..638	CDD:464211	14/90 (16%)
		Protein Kinases, catalytic domain	636..905	CDD:473864	61/346 (18%)
		SAM_superfamily	932..987	CDD:472832	8/55 (15%)