Protein Alignment Ptp4E and LOC569071

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_009295554.2
• Gene: LOC569071 / 569071
• -ID: -
• Length: 1061
• Species: Danio rerio
• Alignment Length: 1222
• Identity: 334/1222 - (27%)
• Similarity: 510/1222 - (41%)
• Gaps: 298/1222 - (24%)

  Fly   510 LIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTRE 574
            |..:.|..:.:..|.:|: |.|          ...:..|...|  |:......|....||:|...
Zfish    10 LCVLSASGQTIPPNVNDV-RIT----------HQTESELTFQW--DIAGSNSGYNYILQRDGIDS 61

  Fly   575 ERTMA--TNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVV 637
            |...|  .|:.:.|:..|..|:.|...:..:..|:||....::.|..|...:::::.....|.:.
Zfish    62 EVITAGIGNQVTYTVSVLSSGTKYNFILFTVFEGLRSSGFPFYSATVPPNVESVSVIDQSENTIT 126

  Fly   638 LHWQAPEGSDFSEYVVRY----RTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESP 698
            |.|: .:.:::| |.::|    .|..||...:      |..:|.:..|.:|...:.||..|::|.
Zfish   127 LQWK-KDKAEYS-YELKYEDKVETPPSPQSTV------EHTVKSLSPGTKYTFTLYTVFEGLKSS 183

  Fly   699 HPLELNVTMPPQPVSNVVPLVDSRN-LTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDL 762
            .....|||:||. |.:|..:..|.| :||:| :.|....||.|::     ||:||....||
Zfish   184 GFSFSNVTVPPN-VESVSVIAQSENEITLQW-KKDKAEYFYELRY-----EDKVETPPSTQ---- 237

  Fly   763 SSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPL--IQSDVFIANAGHEQGQDET- 824
              .:|...::.||||.:|.|.:.....|::|.....|..|:||  |...|.        |::||
Zfish   238 --STVEYLVKSLSPGTKYAFTLYTVFEGLKSSGFSFSAVTVPLDIIGFSVI--------GRNETA 292

  Fly   825 ITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSF---------SGLTPGKLYNVTV 880
            :||.:|...      |.|.:.:        ||  :|.|..:||         :.|:||..|:.|:
Zfish   293 LTLQWTKEK------DEYTYEL--------EK--SDVETHISFTDTTVVCVITSLSPGTEYSYTL 341

  Fly   881 WTVSGGVASLPVQRLYRLH---------PLPISDLKAIQVAAREITLHWTAPAGEYTD---FELQ 933
            :||..||.|         |         |..:..:..::....::.|.|.|...|..:   :.|:
Zfish   342 YTVFEGVKS---------HGHRFADVTVPSNVESVSVVEAIGTDVILQWNAVPNEQNNKYHYILK 397

  Fly   934 YLSADEEAPQLLQNVTKNTEIT--LQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPI 996
            |...:|......:||     ||  :.||.|..||:||:.....|.:.|.: :..:||...|...:
Zfish   398 YSDVEETVDPTDENV-----ITHHVSGLNPATNYSFTLHTEFYSQRSTGY-NFYLSTSSSSITEV 456

  Fly   997 SASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPV 1061
            ..: ::||                 |:|.||:     :....:.:..|...:|.|    ..:|..
Zfish   457 RVT-RSLT-----------------ELTVEWN-----KFNKSNVYNYTLLRSDGA----EIDFTG 494

  Fly  1062 NATQG-----KIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEP-----SVTPL-- 1114
            :|..|     |...|.||..|.|                  |:..:...|.:|     |:|.|
Zfish   495 SAVVGDVITHKYSSLKPGTVYSF------------------TLFTVVDNVRDPGFRFKSITTLDC 541

  Fly  1115 -----EVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAED---VGKNAS----GLEMPSWQDVQA 1167
                 |.:.||...::          :|.    |.:.|:.   .|||||    .:.:......::
Zfish   542 ASFSWEATNTSIVADV----------YGC----TYVTAQSSTGSGKNASIEGDRVNLRDLYPGES 592

  Fly  1168 YTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFT------------IGTANCDKHQAGY------- 1213
            |||.|.|                  :||:|..|            :....|..|..||
Zfish   593 YTVSLFY------------------NLESEMLTQCSQRLTLVPNSVSHLCCKYHSGGYGLAVMWE 639

  Fly  1214 -----------------------CNGP-------LRAGTTYRIKIRAFTDEDKFTDTVYSSPITT 1248
                                   .:.|       |:|...|::...:|:.              .
Zfish   640 YPDGVVDVVEVDVNKKSFNHSHGSDEPTQQLVTGLQAAQWYKVTATSFSG--------------A 690

  Fly  1249 ERSDTVIV-----AATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALP---EGYITP 1305
            .||:|:.:     .|.|.|.:||..:||::.|......||..|  |:..::.:..|   :..||.
Zfish   691 RRSETISINCQTDPAGVIAGVLVFFLLVIIICAGVFVWIRYGS--AKFHNKRSHPPVESKVSITH 753

  Fly  1306 NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRF 1370
            |:.:....|.||:..||.|....||.|::||..||..|:...|.||.|:.|||.:.:||||.||.
Zfish   754 NKTIASDKFPEHFHNMSCDDKRNFSVEYKELGSVGVKQSSVTARLPENKDKNRISYVLPYDSSRV 818

  Fly  1371 KLQPVDDDDGSDYINANYMPGH-NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKG 1434
            .| .|:....|||.||||:||: |..|::|..||||.||..:||||.||..|.||||:|.|.|.|
Zfish   819 HL-TVNKAGDSDYFNANYIPGYGNVSRQYIAAQGPLPSTVNDFWRMVWEQKSSAIVMVTNCTEDG 882

  Fly  1435 REKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVP 1497
            ..||:||||:|.....||::.|.:..:.....|::.||.|..  ..::||:.|||||.|||.|||
Zfish   883 MVKCEQYWPLDNTPCLYGNLLVAVKSENKSESWTLREFHVKNKMTSDTRIVHHFHFTAWPDHGVP 947

  Fly  1498 EPPQSLVRFVRAFRDVIGTDMR--PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAM 1560
            ...:.|::|....|..|.:...  |.:||||||||::||.||||.:||.:::...|.:...|..|
Zfish   948 CGTEDLIQFRELVRQHIESPFSAGPTVVHCSAGVGQTGTLIALDVLLQQLNREKAVGVAAFVKEM 1012

  Fly  1561 RKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVT-KIYL 1611
            |..|..||:||.|||.:|||:|           |||...:...||.| .||:
Zfish  1013 RLSRPLMVETESQYVFLHQCIL-----------DSLPPQSEPIYENTDSIYV 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	58/245 (24%)
		fn3	708..796	CDD:394996	28/88 (32%)
		fn3	902..978	CDD:394996	19/80 (24%)
		fn3	1013..1092	CDD:394996	16/83 (19%)
		PTP_tm	1127..1247	CDD:465889	26/175 (15%)
		R3-PTPc	1358..1579	CDD:350396	102/225 (45%)
LOC569071	XP_009295554.2	FN3	21..87	CDD:214495	18/78 (23%)
		FN3	<57..459	CDD:442628	116/461 (25%)
		PTP_DSP_cys	805..1037	CDD:475123	108/243 (44%)