DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and ptprja

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_005166490.1	Gene:	ptprja / 559679	ZFINID:	ZDB-GENE-030131-8301	Length:	1766	Species:	Danio rerio

Alignment Length:	1739	Identity:	423/1739 - (24%)
Similarity:	699/1739 - (40%)	Gaps:	367/1739 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGK-------DIKFSRALPGTEYNF-- 128
            :|.:|....||...|     ::||:|   .:.....:.:|.       .::.|...|||:|||
Zfish   138 NLSVNSITVSSMILA-----WTPPYG---SSPYYKVAWVGNLAFTNQTSMQISSLSPGTKYNFNV 194

  Fly   129 -WLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDL 192
             .:...|||  |.....::..|:|....|::|...::.|..:.|..| .|....:.:. .....:
Zfish   195 TSVATDNST--EGRPTAISQNTSPAQVQNITVVNYTNSSVTVAWTVP-DGHVDSYTVN-CSTQSI 255

  Fly   193 PFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNE 257
            |     ::..|.|   :...|.||..|.:...|: .|..:.......|.||||.|....|..:..
Zfish   256 P-----NINDNNT---TISSLPPGCLYNLTVTSI-SGVLTNVSNIVQFATKPNPPEAVRVSGQTF 311

  Fly   258 TTLLVLWQPPFP-AGIYTHYRVSITPDDAIQSVLYVEREGEPPG----------PAQAAFKGLVP 311
            :::.:||..|.. :|:...|.||..|   :|           ||          ........|:.
Zfish   312 SSISLLWSTPLSMSGVAVSYGVSYVP---VQ-----------PGVNLPLTQTTSSNMTNITNLLS 362

  Fly   312 GREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQV 376
            |.:|.|:|.|...:..||........|||:.|.|:......|.|.|  :.|.||...|...:|.:
Zfish   363 GTQYTITVVTNGVNNLSSSFINLIGYTVPKIVQNLAVSNVSTNSVS--LTWLPPNGTSSLFSYNI 425

  Fly   377 MLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKT--IADNVNSWPASGEVTLRPRPVRS 439
            .:|:..:.|..  .:|...:     ..|:||..|...|.|  :|.|::......:...:|.||.:
Zfish   426 NISSLGQTFYT--TSNSYQI-----TQLQPGTQYNCYVTTLIVAGNISGPSQFIQCNTKPLPVSN 483

  Fly   440 LGGFLDDRSNALHISWEP---------AETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNL 495
            |.. :...:..:.:||.|         :..|...:|        |:||             ..|:
Zfish   484 LKA-IPVGTTVILLSWTPSTALYLYNVSANGTWSTY--------NSSE-------------GANV 526

  Fly   496 TEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQ 560
            |     .|..|..|...|..::.|::|....|:.:|.....:|.......|.:.:.|.....:
Zfish   527 T-----GLTPGNNYTFTVITVANGLSSEPVTISAFTGLGKAIIISAIGNTQTMTVQWTPPAGT-- 584

  Fly   561 DRYEVHYQR----NGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPK 621
              ..::..|    :||.......|..||:....|.||:.|.|.|.:||..|:.:..|...|..|.
Zfish   585 --VSLYSARILLMDGTVLNTKNQTKTTSMMFSDLLPGTQYSVIVSSISGPVKQDSDSVTNATLPT 647

  Fly   622 PPQNLTLQTVHTNLVVLHWQAP-EGSDFSEY-VVRYRTDASPWQRISGLHENEARIKDMHYGERY 684
            ||..:: .|..||.:.:.|..| ..|..|.| :::|....     :....:|...:..::.|..|
Zfish   648 PPGEIS-TTQSTNTLNISWAQPLNMSSVSYYFLLQYNNST-----LINCSQNYTSLTGLNAGFPY 706

  Fly   685 LVQVNTVSFGVESPHPLELNVTMPPQPVSNV-VPLVDSRNLTLEW----PRPDGH---VDFYTLK 741
            .:.:.||.....|.....|.....|..|:|| |......::||.|    |:..|:   :::.|:.
Zfish   707 NIIMWTVGAMNYSSSSKSLTAFTNPSVVTNVTVNEFTETSVTLSWQQNDPQQSGYSYLLNYKTIN 771

  Fly   742 WWPTDEEDRVEFKNVTQLEDLSSPS-VRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPL 805
              .|..:..|. .|..:||.|.|.| ..|.|..|:||            |.:|....::..:.|
Zfish   772 --GTSNQTTVN-NNTVKLEQLQSASQYNISIIALTPG------------GTKSDPQFITACSRP- 820

  Fly   806 IQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGL 870
                ..:.|.........|:.||:. .|....:...|:..:.:.| |:...::..|| .::.:.|
Zfish   821 ----NRVNNVSSVALNVSTVRLSWA-RPLQYNQLVSYQVLVSNCT-KNSMNMSTSTE-MITVTNL 878

  Fly   871 TPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYL 935
            .||.|..:::::|:.|:...||.......|..:..:...|.:...:.:.|:.|.|. .|..:..:
Zfish   879 QPGTLCQISIYSVACGLLGQPVNTSVLTMPSTVQPVVNSQGSNNSLLVLWSHPDGG-LDMYILNI 942

  Fly   936 SADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVS---------VSTLMR 991
            |:|..:.....|.|:| ..|...|:....||.|:....||.|.|..|.||         ::.|.:
Zfish   943 SSDGWSDFSFLNSTEN-NYTFTQLKAATLYTVTLTTVKGSFQETSGAVVSATYPNSPGMITVLFK 1006

  Fly   992 SSAPISASY---QTLTAPPGKVDY-------------------------------------FQPS 1016
            ::..:...:   |.:|  ||..:|                                     ..|.
Zfish  1007 NTHSVLLHWDIAQNMT--PGSFNYSLSFWSSKNNSLYLTPNNTLLLDGLQSGTPYNVSLATVGPL 1069

  Fly  1017 DVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAA------DVSSYEFPVN-------ATQGKI 1068
            ::|...:.:..:..|    .|:...::.....:..:      ||..|...||       :....|
Zfish  1070 NLQSESMRYNVTTMP----DPVKNLKVVSTTTNTISVTWKMVDVPKYVVSVNNAVKITSSNNMTI 1130

  Fly  1069 DGLVPGNHYIFRIQAKSALGYGAEREHIQ------------------TMPI-------------- 1101
            ..|.|...|...:|:.:......|...:|                  |:|:
Zfish  1131 HNLQPSTQYNISVQSSTFDNTEGEAVCLQDCTDAAPVENVTCVGPNLTLPMLNLFWNHPLGGYMN 1195

  Fly  1102 ----LAPPVPEP------SVTPLEVSRT------------SSTIE-ISFRQGY------------ 1131
                |:..:.|.      :.|.|:.::|            |||:: ||...|:
Zfish  1196 FEVNLSSSISEKTKNLNYNFTGLKYNKTYSVTLRTLGCGKSSTVKNISCTTGFTNPVVPKITAAS 1260

  Fly  1132 -----------------FSNAHGMVRSYTIIIAE------DVGKNASGLEMPSWQDVQAYTVWLP 1173
                             |::::|.|.||.::::.      |..:|.:...:.::.|      |..
Zfish  1261 VSEQQYNKFALVIQSDAFNDSNGTVCSYGLLVSSGSFDCLDNNQNYNQCLLKTYDD------WKA 1319

  Fly  1174 YQAIEPYNPFLTSNGSRKSSLEAEHFTIGT-ANCDKHQAGYCNGPLRAGTTYRIKIRAFT----- 1232
            .|:    :.||....:..|..|.|...||. :..:|    |.||.|.|..||...|.|||
Zfish  1320 KQS----DTFLAVVKTNVSKSELETIIIGDGSKWNK----YTNGELNAKGTYNFAIVAFTLLEVK 1376

  Fly  1233 ----DEDK--FTDTVYSSPITTERSDTVIVAATVS---AVLLVAMVLVVVYC-QHRCQLIRRASK 1287
                |..|  ::.:.|.| :|...:..||..|...   .|::|.:::.:|.| :.:.:.:..:..
Zfish  1377 DGKVDVSKSYYSVSAYQS-VTLPENPVVIGGAAAGVGVTVIIVVIIIGIVACTRKKRKEVSNSVP 1440

  Fly  1288 LARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPC 1352
            :..:::::          :.|:.|:|:..:|:...|||...|:||||:|:.||.:|:.:.|..|.
Zfish  1441 IHSLRNKV----------SDPIKVEDYEAYYKRQRADSFCGFAEEFEDLRPVGINQSKTVAVFPE 1495

  Fly  1353 NRPKNRFTNILPYDHSRFKL----QPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFW 1413
            |:.|||:.|:||||.||.||    .|.|     ||||||||||:.:.:|||..||||..|..:||
Zfish  1496 NKAKNRYNNVLPYDSSRVKLSVLSSPFD-----DYINANYMPGYITKKEFIAAQGPLPGTVNDFW 1555

  Fly  1414 RMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--R 1476
            |:.||.|...|||||:|.|:||.||::|||.:...  :.::.|..|.|....||::.:|.|.  :
Zfish  1556 RLIWEKNVHTIVMLTKCNEQGRVKCEEYWPAEMKT--FSNLTVTTISDIPLEDWTLRDFEVKNMK 1618

  Fly  1477 NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR--PIIVHCSAGVGRSGTFIALD 1539
            ..|.|.:||||||.|||.||||..:.|:.|....|:.:....|  |.:|||||||||:|||||:|
Zfish  1619 TAEIRSVRHFHFTAWPDHGVPETTELLINFRHLVREHMDEYSRHSPTLVHCSAGVGRTGTFIAID 1683

  Fly  1540 RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGK 1588
            |::..|.:...||::||:..:|..|..|||||.|||.::||.:.:::.:
Zfish  1684 RLIFQIERDGVVDVYGIIHDLRMHRPLMVQTEDQYVFLNQCAMDIIKSR 1732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	17/90 (19%)
		fn3	247..328	CDD:278470	19/91 (21%)
		fn3	343..417	CDD:278470	19/75 (25%)
		fn3	443..525	CDD:278470	16/90 (18%)
		FN3	548..611	CDD:238020	16/66 (24%)
		FN3	620..706	CDD:238020	19/87 (22%)
		fn3	708..796	CDD:278470	26/96 (27%)
		fn3	824..886	CDD:278470	14/61 (23%)
		fn3	902..978	CDD:278470	17/75 (23%)
		fn3	1013..1092	CDD:278470	14/91 (15%)
		UP_III_II	1106..>1248	CDD:297589	43/207 (21%)
		PTPc	1329..1582	CDD:214550	124/260 (48%)
		PTPc	1355..1582	CDD:238006	112/234 (48%)
ptprja	XP_005166490.1	fn3	135..197	CDD:278470	16/66 (24%)
		fn3	218..284	CDD:278470	14/76 (18%)
		FN3	298..>371	CDD:238020	19/86 (22%)
		COG3979	391..543	CDD:226487	40/187 (21%)
		fn3	394..469	CDD:278470	21/83 (25%)
		fn3	480..550	CDD:278470	19/96 (20%)
		fn3	565..631	CDD:278470	15/69 (22%)
		fn3	732..806	CDD:278470	23/88 (26%)
		fn3	825..899	CDD:278470	16/76 (21%)
		FN3	1084..1147	CDD:214495	12/66 (18%)
		PTPc	1471..1727	CDD:214550	124/262 (47%)
		PTPc	1499..1727	CDD:238006	112/234 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.050