Protein Alignment Ptp4E and ptpn11

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_012818337.1
• Gene: ptpn11 / 549586
• XenbaseID: XB-GENE-22063677
• Length: 596
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 164/650 - (25%)
• Similarity: 253/650 - (38%)
• Gaps: 190/650 - (29%)

  Fly  1014 QPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYI 1078
            :||...||:.|..     ..::|.:.:.:|  ||..|..|:
 Frog    32 RPSKSNPGDFTLS-----VRRNGAVTHIKI--QNTGDYYDL------------------------ 65

  Fly  1079 FRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYT 1143
                      ||.|:     ...||..|.                       |:...||.::.
 Frog    66 ----------YGGEK-----FATLAELVQ-----------------------YYMEHHGQLKE-- 90

  Fly  1144 IIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEP-----YNPFLTSNGSRKSSLE-AEHFTIG 1202
                    ||...:|:.           .|....:|     ::..|:...:.|...| .:|.:..
 Frog    91 --------KNGDVIELK-----------YPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFL 136

  Fly  1203 TANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVA 1267
            ......|...:.           :.:|  |.:||.......|.:|.
 Frog   137 VRESQSHPGDFV-----------LSVR--TGDDKAESNDGKSKVTH------------------- 169

  Fly  1268 MVLVVVYCQHRCQLIRRASKLARMQDELAALPEGY------ITPNRPVHVKDFSEHYRIMSADSD 1326
               |::.||.....:....|.    |.|..|.|.|      .|....:.:|......||.:|:.:
 Frog   170 ---VMIRCQDLKYDVGGGEKF----DSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIE 227

  Fly  1327 FR-----------------FSEEFEELKHVGRDQACSF------ANLPCNRPKNRFTNILPYDHS 1368
            .|                 |.||||.|    :.|.|..      .....|:.|||:.||||:||:
 Frog   228 SRVKELSKPAETADKFKQGFWEEFETL----QQQECKLLYSRKEGQRQENKNKNRYKNILPFDHT 288

  Fly  1369 RFKLQPVD-DDDGSDYINAN-YMPGH----NSP---REFIVTQGPLHSTREEFWRMCWESNSRAI 1424
            |.:|...| ::..||||||| .||..    |:|   :.:|.|||.|.:|..:||||.::.|||.|
 Frog   289 RVELHDGDPNEQVSDYINANIIMPEFETKCNNPKPKKRYIATQGCLQNTVNDFWRMVFQENSRVI 353

  Fly  1425 VMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR----NCESRIMRH 1485
            ||.|:..|:|:.||.:|||.:.....||.::|:.:.:|..||:.:.|..:|:    |.| |.:..
 Frog   354 VMTTKEVERGKSKCVKYWPDEFALKEYGVMRVRNVKETPAHDYILRELKLSKVGQGNTE-RTVWQ 417

  Fly  1486 FHFTTWPDFGVPEPPQSLVRF---VRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK 1547
            :||.||||.|||..|..::.|   |...:|.| .|..|::||||||:||:||||.:|.::..|.:
 Frog   418 YHFKTWPDHGVPTDPGGVLDFLEEVHHKQDGI-ADAGPVVVHCSAGIGRTGTFIVIDILIDVIRE 481

  Fly  1548 SDY---VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKI 1609
            ...   :|:...:..:|.:|..|||||.||..|:..:...:|..:..:.:. :.....|:|.|.|
 Frog   482 KGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEE-QKSKRKGHEYTNI 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996
		fn3	1013..1092	CDD:394996	13/77 (17%)
		PTP_tm	1127..1247	CDD:465889	18/125 (14%)
		R3-PTPc	1358..1579	CDD:350396	97/239 (41%)
ptpn11	XP_012818337.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	24/160 (15%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	22/145 (15%)
		PTPc-N11	272..524	CDD:350453	100/253 (40%)