DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprh

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_011248936.1	Gene:	Ptprh / 545902	MGIID:	3026877	Length:	1153	Species:	Mus musculus

Alignment Length:	1270	Identity:	364/1270 - (28%)
Similarity:	528/1270 - (41%)	Gaps:	217/1270 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 NVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSN- 449
            :|.||| |.||..|..   .|..:||..:....|.|:|.|.....|..|.|||:|.  ::.::|
Mouse    23 SVVRAA-GTSVTVDRH---APASSYEFSMWVEKDGVSSSPQIPVTTAAPNPVRNLR--VEGQNNI 81

  Fly   450 ALHISWEPAETGRQDSYR-ISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAV 513
            ::.:||||.:   |.|.: ::|..|.:.      .....|::.||: |..|:|.|..|..|..:|
Mouse    82 SISLSWEPPD---QSSLQGLTYWTQCSR------HGGQTETRNTTD-TSVTVDGLDPGSSYECSV 136

  Fly   514 QALSKGVASNASDITRYTRPAAPLIQELRSIDQ---GLMLSWR-SDVNSRQD-RYEVHYQRNGTR 573
            .....|:.|....:...|.|..  ::.||...|   .:.|||. .|.:|.|. .|.....|:|.:
Mouse   137 WVEKDGLYSKNETLNTSTAPNP--VRNLRVEGQNNISISLSWEPPDQSSLQGLTYWAQCSRHGGQ 199

  Fly   574 EERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVL 638
            .| |..|.:||:|:..|.|||.||..|.....||.|...:......|.|.:||.::..:...:.|
Mouse   200 TE-TRNTTDTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLSNTTAPNPVRNLRVEGQNNISISL 263

  Fly   639 HWQAPEGSDF-------------SEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNT 690
            .|:.|:....             .:...|..||.|  ..:.||..          |..|...|..
Mouse   264 SWEPPDQPSLQGLTYWAQCSRHGGQTETRNTTDTS--ITVDGLDP----------GSSYECSVWV 316

  Fly   691 VSFGVESPHPLELNVTMPPQPVSNVVPLVDSRN---LTLEWPRPDGHVDFYTLKWWPTDEEDRVE 752
            ...||.|.:. .|:.|..|.||.|:  .|:.:|   ::|.|..|| ......|.:|....
Mouse   317 EKDGVYSTNE-TLSNTTAPNPVRNL--RVEGQNNISISLSWEPPD-QPSLQGLTYWAQCS----- 372

  Fly   753 FKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGH 817
             ::..|.|..::....:.::.|.||..|...|....:|:.|....|:|.|:| |.:...:.|...
Mouse   373 -RHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTVP-ISAPNPVRNLRV 435

  Fly   818 EQGQDETITLSYTPTPADSTRFDIYRFSM---GDPTIKDKEKLANDTERKLSFSGLTPGKLYNVT 879
            |...:.:|:||:.|....|.:...|....   |..|     :..|.|:..::..||.||..|..:
Mouse   436 EGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGGQT-----ETRNTTDTSITVDGLDPGSSYECS 495

  Fly   880 VWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQL 944
            ||....||.|..........|.|:.:|:........|:|.|..|........:.:........|.
Mouse   496 VWVEKDGVYSTNETLSNTTAPNPVRNLRVKSQNNFSISLSWEPPDQPSLQGLIYWAQCSRHGGQT 560

  Fly   945 LQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGK 1009
            ....|.:|.:|:.||.|...|..:|.|....:..|:      .||..|:.|||||......   :
Mouse   561 ETRNTTDTSVTVDGLDPGFLYKCSVWVEKDGVYSTN------ETLNTSTVPISASNPVRNL---R 616

  Fly  1010 VDYFQPSDVQPGEVTFEWSL--EPAEQ--------------HGPIDYFRITCQNADDAADVSSYE 1058
            |:         |:..|..||  ||.:|              ||.....|.|       ||
Mouse   617 VE---------GQNNFSISLSWEPPDQSSLQGLTYWAQCSRHGGQTETRNT-------AD----- 660

  Fly  1059 FPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTI 1123
                 |...:|||.||:.|...:..:.. |..:..|.:.|           |..|..|:.||.
Mouse   661 -----TSVTVDGLDPGSSYECSVWVEKD-GVYSTNETLNT-----------STVPAAVNITSC-- 706

  Fly  1124 EISFRQGY-----FSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPF 1183
             ||...||     :|...|...|:.:    .||:        .|:
Mouse   707 -ISTSGGYGVLLTWSCPSGGYESFEV----KVGR--------KWR-------------------- 738

  Fly  1184 LTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITT 1248
             :.|||.               |.|   |.....|....:|...:...     |.|....|..||
Mouse   739 -SENGSL---------------CGK---GVTVSDLEPAQSYTATVTTV-----FKDLKAQSLSTT 779

  Fly  1249 --ERSDTVIVAATVSAVLLVAMV-LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVH 1310
              ..|..:|..|.|..:||..:| |::|:.:.|    |:..:...:..:|.....|.|.
Mouse   780 CHTESAAIIAGAIVGILLLFILVGLLIVFLKRR----RKKRQPKEVPKDLVCSCPGDIL------ 834

  Fly  1311 VKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPV 1375
            .|||::|.|....||:..|:||:::|...|:.|:...|:...||.|||:.|:||||.||..|||:
Mouse   835 AKDFADHVRENEKDSNCGFAEEYQQLALEGQGQSQITASALENRSKNRYRNVLPYDWSRVPLQPL 899

  Fly  1376 DDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQ 1440
            .::.|||||||::|||..||:|||.|||||.:|..:||||.||..|..:||||.|.|.||.||:.
Mouse   900 QEEPGSDYINASFMPGLWSPKEFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMESGRVKCEH 964

  Fly  1441 YWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRI--MRHFHFTTWPDFGVPEPPQSL 1503
            |||:|.....:|.::|.||.:....:|::....:....|.:.  :|.||:..|||.|||..|..|
Mouse   965 YWPLDAQPCIHGQLQVMLISEEASENWTVRHLQLFHMKEQQTLSLRQFHYLAWPDHGVPYSPDPL 1029

  Fly  1504 VRFVRAFRDVIG--TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVF 1566
            :.|.:..|..:.  ||..|.||||||||||:||.||||.:|:.:.....|..|..|..||:.|..
Mouse  1030 LAFRKMLRQWMDQTTDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFSFVKKMRESRPL 1094

  Fly  1567 MVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHAN 1601
            |||||.|||.:|||:|..|:.....|.....::.|
Mouse  1095 MVQTEAQYVFLHQCILKSLQKPAPALVPEEAMYEN 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470	11/30 (37%)
		fn3	443..525	CDD:278470	21/83 (25%)
		FN3	548..611	CDD:238020	25/64 (39%)
		FN3	620..706	CDD:238020	20/98 (20%)
		fn3	708..796	CDD:278470	21/90 (23%)
		fn3	824..886	CDD:278470	17/64 (27%)
		fn3	902..978	CDD:278470	16/75 (21%)
		fn3	1013..1092	CDD:278470	21/94 (22%)
		UP_III_II	1106..>1248	CDD:297589	26/146 (18%)
		PTPc	1329..1582	CDD:214550	120/256 (47%)
		PTPc	1355..1582	CDD:238006	111/230 (48%)
Ptprh	XP_011248936.1	FN3	67..146	CDD:238020	25/90 (28%)
		FN3	156..234	CDD:238020	28/80 (35%)
		FN3	245..323	CDD:238020	18/89 (20%)
		FN3	334..412	CDD:214495	20/86 (23%)
		FN3	427..505	CDD:238020	21/82 (26%)
		FN3	516..594	CDD:238020	17/77 (22%)
		FN3	611..687	CDD:214495	22/105 (21%)
		PTP_DSP_cys	881..1113	CDD:391942	111/231 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920