Protein Alignment Ptp4E and Ptpro

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_059032.1
• Gene: Ptpro / 50677
• RGDID: 62068
• Length: 1216
• Species: Rattus norvegicus
• Alignment Length: 1337
• Identity: 335/1337 - (25%)
• Similarity: 533/1337 - (39%)
• Gaps: 380/1337 - (28%)

  Fly   445 DDRSNALHISWEPAE------------TGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTE 497
            ||  |.:.:|.|.::            .|...:|...:.|.......|..|.....
  Rat    36 DD--NNIVVSLEASDVVSPTSVYVVRVAGESKNYFFEFEESNGTLPPPVVFKATYH--------- 89

  Fly   498 YTLDSLLAGRRYLIAVQALSKGVASNAS-DITRYTRP----AAPLIQELRSIDQGLMLSWRSDVN 557
                    |..|:|::..:|..|.:..| .||..|:|    :..:.....|.:.|::
  Rat    90 --------GLYYIISLVVVSGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVL-------- 138

  Fly   558 SRQDRYEVHYQRNGT------------REERTMATNE----TSLTIHYLHPGSGY-EVKVHAISH 605
                 :|:||.....            ::.|||...:    .::..|:| ||..| .:....:|.
  Rat   139 -----FEIHYPEKYNVFSRVNISYWEGKDFRTMLYKDFLKGKTVFNHWL-PGICYSNITFQLVSE 197

  Fly   606 ------------GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGS------------ 646
                        ||..||..:..|  |.||:|::::.|  ||...:|:.|.||
  Rat   198 ATFNKSTLVECSGVSHEPKQHRTA--PYPPRNISVRFV--NLNKNNWEEPSGSFPEDSFIKPQDA 258

  Fly   647 -------DFSEYV-----------------VRYRTDASP--WQRISGLHENEARIKDMHYGERYL 685
                   .|.|..                 ..|.:.:.|  |...|...|||   :|       .
  Rat   259 IGRDRPFHFPEETPETPASNASSGWPDPNGTEYESTSQPYWWDSASAAPENE---ED-------F 313

  Fly   686 VQVNTVSFGVE--------------SPHPLELNVT-MPPQPVSNVVPLVDSRNLTLEWPRPDGHV 735
            |.|....:..|              |..|:::.:: :||:|.:    ..|..|:.:|  |.....
  Rat   314 VSVLPADYDTEATLGRTEKPTADPFSAFPVQMTLSWLPPKPPT----AFDGFNILIE--REGNFT 372

  Fly   736 DFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQA-SSNGIRSGTTHLS 799
            |:.|:      :|:..||  |.:|::              ||: ||..|.. ||:|........|
  Rat   373 DYLTV------DEEAHEF--VAELKE--------------PGK-YRLSVTTFSSSGACETRKSQS 414

  Fly   800 TRTMPLIQSDVFIANAGH------EQGQ--------DETITLSYTPTPADSTRFDIYRFSMGDPT 850
            .:::     ..:|:..|.      |:.|        ..|..||:|.:..:.....:...|:....
  Rat   415 AKSL-----SFYISPTGEWIEELTEKPQHVSVHVLSSTTALLSWTSSQENYNSTIVSVVSLTCQK 474

  Fly   851 IKDKEKLAND-----TERKLSFSGLTPGKLYNVTVWTVSG---GVASLPVQRLYRLHPLPISDLK 907
            .|:.::|...     ...|.....|.||..|.|.::...|   |..|.||  .:.:.|..|.||.
  Rat   475 QKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSDPV--TFAIVPTGIKDLM 537

  Fly   908 AIQVAAREITLHWTAP-AGEYTDF--ELQYLSADEEAP------QLLQNVTKNTEITLQGLRP-- 961
            ...:....:.|.||.| .|.:..:  |:.|.:......      ::...|:..:.:.:..|.|
  Rat   538 LYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPTTMTSEWTTYYEIAATVSLTSSVRIANLLPAW 602

  Fly   962 YHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFE 1026
            |:|:..|:|.         :.|..:|..  .|:.||    .:|||           |.| |:|
  Rat   603 YYNFRVTMVT---------WGDPELSCC--DSSTIS----FITAP-----------VAP-EIT-- 638

  Fly  1027 WSLEPAEQHGPIDYFR----ITCQNADDAADVSSYEFP--VNATQGK--------------IDGL 1071
                      .::||.    |:....|...|:|.....  :...:|:              |..|
  Rat   639 ----------SVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRRKIKKSVTRNVMTAILSL 693

  Fly  1072 VPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAH 1136
            .||:.|...:.|.:..|.......:    :...|.|..|:..:..::||.|: :...:|
  Rat   694 PPGDIYNLSVTACTERGSNTSMLRL----VKLEPAPPKSLFAVNKTQTSVTL-LWVEEG------ 747

  Fly  1137 GMVRSYTIIIAEDVGKNASG-LEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFT 1200
              |..:..::.:.:|....| |:.|  ..|.::.|                             |
  Rat   748 --VADFFEVLCQKLGSGHDGKLQEP--VAVSSHVV-----------------------------T 779

  Fly  1201 IGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT-VYSSPITTERSDTVIVAATVS--A 1262
            |.:              |...|.|...:.:|:.:.....| :..|.:.||.:..|:|.:.::  :
  Rat   780 ISS--------------LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEVNPNVVVISVLAILS 830

  Fly  1263 VLLVAMVLV--VVYCQHRCQLIRRAS-----KLARMQDE--------------LAALPE------ 1300
            :||:.::||  |:..:...|:.|...     ..|.::.|              |..||.
  Rat   831 ILLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFTFLTLLPSCLWTDY 895

  Fly  1301 ---GYITP-----------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLP 1351
               .||.|           ..||.:.||..:.:.|:.|||::||.:|||||.:|.|.....|:||
  Rat   896 LLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP 960

  Fly  1352 CNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMC 1416
            .||.|||:|||||||.||.:|..:::::|:|||||||:||:|||:|:|.|||||..||.:||:|.
  Rat   961 LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMV 1025

  Fly  1417 WESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESR 1481
            .:..||.|||||:|.||.|.|||.|||.....:.||||.|:::.:....||:...|.::...|::
  Rat  1026 LQQKSRIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEQEDWASRHFRINYADEAQ 1090

  Fly  1482 IMRHFHFTTWPDFGVP--EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQH 1544
            .:.||::|.|||.|||  ...:|:::||...|........|:|:||||||||:||||||||:|||
  Rat  1091 DVMHFNYTAWPDHGVPPANAAESILQFVYTVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 1155

  Fly  1545 IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581
            |...::|||.|:|..||..|:.|||||:||:.||||:
  Rat  1156 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	74/402 (18%)
		fn3	708..796	CDD:394996	22/88 (25%)
		fn3	902..978	CDD:394996	17/86 (20%)
		fn3	1013..1092	CDD:394996	18/98 (18%)
		PTP_tm	1127..1247	CDD:465889	16/121 (13%)
		R3-PTPc	1358..1579	CDD:350396	113/222 (51%)
Ptpro	NP_059032.1	FN3	434..526	CDD:238020	20/93 (22%)
		FN3	530..630	CDD:238020	23/114 (20%)
		fn3	725..805	CDD:394996	19/133 (14%)
		R-PTPc-O	951..1195	CDD:350462	124/242 (51%)