Protein Alignment Ptp4E and Ptpn13

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_038948202.1
• Gene: Ptpn13 / 498331
• RGDID: 1563360
• Length: 2465
• Species: Rattus norvegicus
• Alignment Length: 1738
• Identity: 376/1738 - (21%)
• Similarity: 613/1738 - (35%)
• Gaps: 506/1738 - (29%)

  Fly    83 SNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALP--GTEYNFWLYYTN-STHREQLTWT 144
            :|:.:...::.||.....|.::::  .|.|:......:||  |...:...:..| |.|:.   |:
  Rat  1014 NNSKSVASLNRSPERRSHESDSSV--EDPGQAYVVGMSLPSSGKSSSQVPFKDNDSLHKR---WS 1073

  Fly   145 VNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVL-------GLTDL-----PFER- 196
            .  .::|:....| |.|:......:.::..|.|:.....:.|.       |..||     |.:|
  Rat  1074 T--VSSPEREITL-VNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRL 1135

  Fly   197 ----SYSLEG------NETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFI 251
                |.||||      .:.||.:.:::|         ..:.|.||..       |..|:||..|.
  Rat  1136 ISVNSVSLEGVSHHAAVDILQNAPEDVT---------LVISQPKEKP-------TKVPSTPVHFA 1184

  Fly   252 VWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGP----AQAAFKGLVPG 312
            ...:|.|.                 :.|...|.|:..   .|.:..|.||    .::.| ||..|
  Rat  1185 NGMKNYTK-----------------KPSSMQDSAMDP---SEDQPWPRGPLRHVPESPF-GLSSG 1228

  Fly   313 -REYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQV 376
             ||.::|.|. |..|::|              |:.:....:.||......|:.|:..|.
  Rat  1229 LREGSLSSQD-SRTESAS--------------LSQSHVNGFFTSHLGDRGWQEPQHSSP------ 1272

  Fly   377 MLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLG 441
                                        .|..|.::..||.:|:..| ||..:.|.   .|..|.
  Rat  1273 ----------------------------SPPVTSKITEKTFSDSYRS-PARRQGTC---DVTELP 1305

  Fly   442 GFLD-DRSNALHISWEPAETGRQD-SYRISYHEQTNASEVPAPFPVAAES-QITTNLTEYTL--- 500
            |..| |..:..:.|.:..:..:|: |..:...::.:.:..|.|.|...:: ::....|:.:|
  Rat  1306 GCADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGIS 1370

  Fly   501 -----------DSLLAGRRYLIAVQALSKGVASNASDITRYTRPAA------------PLIQELR 542
                       .|:..|..|:.||  :..|.|.....|.:..|..|            ..::.||
  Rat  1371 VTVLFDKGGVNTSVRHGGIYVKAV--IPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1433

  Fly   543 SIDQ--GLMLSWRSDVNSRQ-----------DRYEVHYQRNGTREERTMATNETSLTIHYLHPGS 594
            :..|  .|:|.......||:           |: :...|.....|::|....:.|    ::...:
  Rat  1434 NTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQ-DAQSQAPEKMEKQTAHVKDYS----FVTEDN 1493

  Fly   595 GYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLH-----WQAPEGSDFSEYVVR 654
            .:|||:...|.|:...        |.: ..|||.:.::.::|.:.     ..|.|....:...|.
  Rat  1494 TFEVKLFKNSSGLGFS--------FSR-EDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVI 1549

  Fly   655 YRTDASPWQRISGLHEN-----------EARIKDMHYGERYLVQVNTVSF-GVESPHPLELNVT- 706
            .:.:.:|   :.||.:.           |..:.........|.:|||... .:.||....||..
  Rat  1550 LKVNGAP---LKGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRK 1611

  Fly   707 --MPPQPVS-NVVPLVDSRNLTLEWPR---PDGHVDFYTLKWWPTDEEDRVEFKNV--------- 756
              ..|.|:| ......|...|:.:..|   |....:.|      :|..|..|.::|
  Rat  1612 EHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESY------SDHSDSGEEESVRAAAKMPNV 1670

  Fly   757 ------------TQLEDLS--------------SPSVRIPIE-DLSPG--RQYRFEVQASSNGIR 792
                        :|.|..|              |.|.|:|.. |:|||  ||...|. |.|:...
  Rat  1671 IPLSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAEC-APSDSPG 1734

  Fly   793 SGTTHLSTR-----TMPLIQSDVFIANAGHEQGQDETITLSYTPTPAD--STRFDIYRFSM---- 846
            ...|||:::     .|..:::|:    ..|.:..:..:.|..|...::  |..|.:.:.|.
  Rat  1735 KHLTHLASQLHKEENMTALKNDL----GNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGC 1795

  Fly   847 -----------GDPTIKDKEKL--ANDTERKLSFSGLTPGKLYNV------TVWTVSGGVASLPV 892
                       ||..::..::|  .||.:    .:.:|.....|:      ||..|.|.:..||.
  Rat  1796 YVHDVIQDPAKGDGRLRPGDRLVKVNDAD----VTNMTHTDAVNLLRAAPKTVRLVIGRILELPR 1856

  Fly   893 QRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQ 957
            ..::                                             |.||.::|    :|..
  Rat  1857 MPVF---------------------------------------------PHLLPDIT----VTCH 1872

  Fly   958 GLRPYHNYTFTVVVRSGSIQGTDF-ADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPG 1021
            |    ....|::....||..|..: :|::    .||:|.:..|.|.|..    :.|
  Rat  1873 G----EELGFSLSGGRGSPHGVVYISDIN----PRSAAAVDCSLQLLDI----IHY--------- 1916

  Fly  1022 EVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDG--LVPGNHYIFRIQAK 1084
                   :.....||      :|.:.|:.|.|:|.....:..|:   ||  :||       ...:
  Rat  1917 -------VNGVSTHG------MTLEEANRALDLSLPSVVLKVTR---DGCPVVP-------CSTR 1958

  Fly  1085 SALG--YGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMV-------- 1139
            ||:.  ...|...:.:|    .|..:|::||.:          ||.:.....|.|.:
  Rat  1959 SAISALRPLEANGLSSM----EPYGQPALTPKK----------SFSKVNGDGASGAMCPGGKGLS 2009

  Fly  1140 ----RSYTIIIAEDVG-KNASGLEMPSWQDVQAYTVWLPYQAI------EPYNPFLTSNGSRKSS 1193
                :|..::.|.|.. :.:...:...:.|.|...|   .|::      |..|....:..||::.
  Rat  2010 SPRKKSADLMEARDFSFQESDSRDDDVYDDPQEAEV---IQSLLDVVDEEAQNLLNQTKASRRAC 2071

  Fly  1194 LEAEHFTIGTANCDKHQAGYCNG-PLRAGTTYRIK-----------IRAFTDED--KFTDTVYSS 1244
            ......|.|.|:.|..... |:| ||.......:.           |:|..:|.  |...|..|.
  Rat  2072 SPDPLRTNGEASEDGEDTD-CDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESR 2135

  Fly  1245 PITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK--LARMQDELAALPEGYITPNR 1307
            ..|||.:|.                             ..:||  |....:||||||...:.|:.
  Rat  2136 ESTTETTDR-----------------------------EDSSKDPLFLTNEELAALPVVRVPPSG 2171

  Fly  1308 PVHVKDFSEHYRIMSADSDFRF-SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFK 1371
            ...........|.:....|... |:|.|.|:.:.....|.......||.|||:.||||||.:|.
  Rat  2172 KYTGTQLQATIRTLQGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRV- 2235

  Fly  1372 LQPVDDDDGSDYINANYMPGHNSPREF--IVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKG 1434
              |:.|:.|  ||||:::......:||  |..||||.:|..:||:|.||.||..|.|:|:..|..
  Rat  2236 --PLGDEGG--YINASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGE 2296

  Fly  1435 REKCDQYWP--VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTT 1490
            :.||.:|||  :....|....:::.|:     ....:..|:|.       :..|.|.:.|.:||.
  Rat  2297 KIKCQRYWPSILGTTTMANERLRLALL-----RMQQLKGFVVRVMALEDIQTGEVRHISHLNFTA 2356

  Fly  1491 WPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFG 1555
            |||...|..|:.|:.|:...|.:..:.  |:|.|||||:|||||.|.:|.:|..|.:....||..
  Rat  2357 WPDHDTPSHPEDLLTFISYMRHIRRSG--PVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISD 2419

  Fly  1556 IVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDG 1603
            :|..||.:|..|||||.|||..:|.:|.||   .||.|:  |..|..|
  Rat  2420 LVRCMRLQRHGMVQTEGQYVFCYQVVLYVL---THLQAE--EQKAQPG 2462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	60/270 (22%)
		fn3	247..328	CDD:394996	21/85 (25%)
		FN3	319..>749	CDD:442628	88/495 (18%)
		fn3	708..796	CDD:394996	28/129 (22%)
		fn3	902..978	CDD:394996	9/75 (12%)
		fn3	1013..1092	CDD:394996	14/82 (17%)
		PTP_tm	1127..1247	CDD:465889	28/152 (18%)
		R3-PTPc	1358..1579	CDD:350396	86/231 (37%)
Ptpn13	XP_038948202.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	564..659	CDD:340715
		B41	566..774	CDD:214604
		PH-like	770..870	CDD:473070
		PDZ1_PTPN13-like	1081..1172	CDD:467285	21/100 (21%)
		PTN13_u3	1168..1356	CDD:465189	54/268 (20%)
		PDZ2-PTPN13_FRMPD2-like	1354..1445	CDD:467254	17/92 (18%)
		PDZ3_PTPN13_FRMPD2-like	1494..1583	CDD:467181	17/100 (17%)
		PDZ4_PTPN13-like	1767..1851	CDD:467182	16/87 (18%)
		PDZ5_PTPN13-like	1862..1948	CDD:467183	25/126 (20%)
		PTPc-N13	2216..2449	CDD:350445	92/244 (38%)