DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and CG42327

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	1498	Identity:	311/1498 - (20%)
Similarity:	516/1498 - (34%)	Gaps:	412/1498 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 QVMLSTSR--RIFNVPR---------AANGDSVYFDYPDILEPGRTYEVVVKTIAD--------N 420
            |.|.|||.  .|...||         |...:|..|.....:|..::.:.|.:|...        |
  Fly    35 QAMASTSTDPDIVKAPRESGIGREPVAIKAESDMFSSQTNIEDEKSAKTVDQTETQTASPKENLN 99

  Fly   421 VNSWPASGEVTLRPRPVRS-LGGFLDDRSNALHISWEPAETGRQDSYRISYHE----QTNASEVP 480
            |....|:.|.........| |.|...|....|..:...|:|.:::|...:..:    .||.::..
  Fly   100 VKQTTAAFEKNESSNTTESHLNGAQVDPVKELKDTETSADTVKEESSTTTTSQLDQNPTNVTDKK 164

  Fly   481 APFPVAAESQITTNLTEYTLDSLL----AGRRYLIAVQALSKGVA--------SNASDITRYTRP 533
            :......:.:::..:...|.:.:|    |.::|::...:..:|.|        |.::...:.|.|
  Fly   165 STEAQFKDERLSKEILSTTTEQILLTEKALQKYVVITNSPLRGEAQPEIKDKTSKSATSEKSTLP 229

  Fly   534 AAPLIQELRS-IDQGLM--LSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSG 595
            ..|:..|:.| ..:|:.  .:.||..:.|..:|      :.|.||.:.::           |.|.
  Fly   230 LKPVTIEVPSTTTEGVFNTTTTRSSDHGRSMQY------SSTTEESSRSS-----------PASV 277

  Fly   596 YEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDAS 660
            ..:|:  |...:.|.|.|......|.|...::..:                  :|.|:...|..|
  Fly   278 TPMKL--IPLPMTSTPSSTTSTSTPLPTTAVSFAS------------------NENVIEESTSKS 322

  Fly   661 -----PWQRISGLHENEARIKDMHYGERYLVQVNTVSF----GVESPHPLELNVTMPPQPVSNVV 716
                 |.:|...:.||....:.       |...||...    |:::       |...|...:..|
  Fly   323 EVRQLPEKRAKFISENSTNAQQ-------LTLPNTAEVWSLAGMKA-------VPKAPLTTTTSV 373

  Fly   717 PLVDSRNLT--LEWP--RPDGHVDFYTLKWW-----PTDEEDRVEF---------KNVTQ----- 758
            ||::..:|.  ::.|  :.:.|.:...|.|.     |...|:|.||         :..||
  Fly   374 PLLNHTDLANDIDMPLNKTELHKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATEGATQATTEA 438

  Fly   759 -LEDLSSPS---VRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTM--PLIQSDVFIANA-- 815
             :|:..|.|   |.:..::::..|.........|..:...||.:.|:.:  ||::.....|||
  Fly   439 LVEETHSKSDITVGLEQDNVTTARTMPSTPDPGSMDLNMTTTTVRTQQLEVPLVKKMSDAANAKL 503

  Fly   816 ----GHEQGQDETIT--LSYTPTP-----------ADSTRFDIYRFSMGDPTIKDKE-KLANDTE 862
                ...|.:.|..|  .::...|           .|||:.::...:......:..| ..||.|:
  Fly   504 IEAVTEPQRETEAATEAATFVTLPEKLATFGITARVDSTQTELLNVTTAAAATESGEMSKANSTD 568

  Fly   863 -------------RKLSFSGLTP------GKLYNVTVWTVSGGVASLPVQRLYRLHPL-----PI 903
                         |.:|...:||      ......|..|.||...:..........|:     ..
  Fly   569 TLSAMTSTTTTTARPMSVEHVTPEQDMEAATSLATTAATSSGTTEAAATSSTTAATPVVSEAATA 633

  Fly   904 SDLKAIQVAAREITLHWTAPAGEYTDFELQYLSA-------DEEAPQLLQNVTKNTE----ITLQ 957
            ::..|...|....||.....|...|:..::....       |:.:..::...||..|    .|..
  Fly   634 AEASATSEATTAATLSVATTAASTTEIAMKATQISNIRDDNDDNSNDVIVATTKFPESEQAATTA 698

  Fly   958 GLRPYHNYTFTVVVR-SGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPG 1021
            .:.|   .|.:|.|| :|.:..:...::.|::...|:...:::..|..|.|.:.:..|.|:
  Fly   699 SVEP---TTTSVSVRVAGEVSTSIRPEIIVTSTRNSTIVDTSTSATSVATPTQTEIAQISN---- 756

  Fly  1022 EVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSA 1086
            ||..|               .:|.:..|..:|.:...     |..|.|..| .|..........|
  Fly   757 EVNLE---------------AVTVKTRDGLSDTNELR-----TAEKTDNAV-NNSVAITESDLGA 800

  Fly  1087 LGYGAEREHIQTMPIL---------------------APPVPEPSVTPLEVSRTSSTIEISFRQG 1130
            |....|.....|..:|                     |||   .|.||...:..:...:.|....
  Fly   801 LATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPP---ESTTPAAPATVAVATDESTAAP 862

  Fly  1131 YFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLE 1195
            ..:....:||.         |::..|.::...||.:        |.:......:|:..:..::..
  Fly   863 AATGGQEIVRE---------GQHHDGQQVADEQDTE--------QQLAKTTMAVTTTTTSATTTT 910

  Fly  1196 AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPI---------TTERS 1251
            ....|..|..           ||...|...::|....|....|.|..:.|:         ||.||
  Fly   911 TSTTTTTTET-----------PLTTTTMQPVEISLLDDSTTTTTTTPAPPVYFESSTVASTTIRS 964

  Fly  1252 DT--------------------------------------------VIVAATVSAVLLVAMVLVV 1272
            .|                                            ||:|.|||.:.:||::|:|
  Fly   965 STTMLPETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLV 1029

  Fly  1273 VYCQ------------HRCQLIRRASKLARMQDELAALPEGYI-TPNRPVHVK----------DF 1314
            .:..            .||   |..|..|...|.::.|  |.: ...|.:...          |.
  Fly  1030 AFLYLMRKRQKQTSYGQRC---RPVSLDAYSLDNVSVL--GSVRRKGRDMRASKRTYGNAAFDDP 1089

  Fly  1315 SEHYRIMSADSDFRF----SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPV 1375
            |..:.:::|....||    |:.|||.:.|.:..|.:....|....|||:.|::|...:|..||..
  Fly  1090 SLRHNLLTASELARFVERRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQ 1154

  Fly  1376 DDDDGSDYINANYMPG-HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439
            .|||.::||||||:.| .::|..:|..|.||.||..:||||.||..||.|:..|...|.|.|:|.
  Fly  1155 GDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCA 1219

  Fly  1440 QYWP----VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPE 1498
            :|.|    :|..:. |||.:|.|........::||..::.|  ..|||.:.|:.: .||:.|||.
  Fly  1220 EYLPPSATLDNHSS-YGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPA 1282

  Fly  1499 PPQSLVRFVRAFRDVI-----------------------------------------------GT 1516
            ....::..:...|..:                                               ||
  Fly  1283 EEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGT 1347

  Fly  1517 --DMRPIIVHCSAGVGRSGTFIALD---RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVC 1576
              ...|:.||||.|.||:||.||.|   |.|:...:|  |||..:|:.:|:.|...|||::||..
  Fly  1348 RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRS--VDIPQLVYYVRRGRASAVQTKEQYEF 1410

  Fly  1577 IHQ 1579
            |::
  Fly  1411 IYK 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470	13/52 (25%)
		fn3	443..525	CDD:278470	14/97 (14%)
		FN3	548..611	CDD:238020	12/64 (19%)
		FN3	620..706	CDD:238020	14/94 (15%)
		fn3	708..796	CDD:278470	22/114 (19%)
		fn3	824..886	CDD:278470	16/94 (17%)
		fn3	902..978	CDD:278470	17/87 (20%)
		fn3	1013..1092	CDD:278470	15/78 (19%)
		UP_III_II	1106..>1248	CDD:297589	22/150 (15%)
		PTPc	1329..1582	CDD:214550	98/314 (31%)
		PTPc	1355..1582	CDD:238006	90/284 (32%)
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	90/284 (32%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	90/284 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100