DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptp69D

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster

Alignment Length:	1272	Identity:	281/1272 - (22%)
Similarity:	492/1272 - (38%)	Gaps:	261/1272 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   528 TRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQD--RY-------EVHYQRNG--TREERTMATN 581
            |||.....|    |:|.|.|      |:.|..||  :|       :|:.:.:|  |...:|...:
  Fly    66 TRYKIRTEP----LKSNDDG------SENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNH 120

  Fly   582 ETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGS 646
            .|...:....|....:.....|...::.:...|  .:....|||   :|.:.|   |.| ..:||
  Fly   121 STEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLY--CLIEMYPQN---ETTNRN---LKW-LKDGS 176

  Fly   647 DFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLEL---NVTMP 708
            .| |::       ..:..||.|::..... .:.:.|.|..:..|....|.....||:   .:|:.
  Fly   177 QF-EFL-------DTFSSISKLNDTHLNF-TLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLF 232

  Fly   709 PQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPS------- 766
            ...|..|         ::::.:..|....| |.|...|..|.:: |....|::..:|:
  Fly   233 VMEVPQV---------SIDFAKAVGANKIY-LNWTVNDGNDPIQ-KFFITLQEAGTPTFTYHKDF 286

  Fly   767 -----VRIPIEDLSPGRQYRFEVQASSNGIRSG-TTHLSTRTMPLIQSDVFIANAGHEQGQDETI 825
                 ....::...|...|...: ...|.|.:| .|........|....:||...........||
  Fly   287 INGSHTSYILDHFKPNTTYFLRI-VGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTASTI 350

  Fly   826 TLSYTPTPADSTRFDIY---------------------RFSMGDPTIKDKEKLANDTE-RKLSFS 868
            |:.:.|.|.|...:..|                     :.|...|.:.||.|.|.|.| |..:.|
  Fly   351 TIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACS 415

  Fly   869 GLTP--GKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPA---GEYT 928
            .||.  |........|...|||:.|.....:.|...::       ....|.::|..|.   |:..
  Fly   416 DLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVT-------RGNSIAINWDVPKTPNGKVV 473

  Fly   929 DFELQYL-----SADEE--APQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSV 986
            .:.:..|     :.|.|  .|::.:....:.:...:.:.|..|||.||              .::
  Fly   474 SYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTV--------------SAI 524

  Fly   987 STLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLE---P--AEQHGPIDYF----- 1041
            :...::..|.:.|.....:.|..:.....|.|   .:..::.|:   |  :|::|||..:
  Fly   525 TRHKKNGEPATGSCLMPVSTPDAIGRTMWSKV---NLDSKYVLKLYLPKISERNGPICCYRLYLV 586

  Fly  1042 RITCQNAD----DAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQA----KSALGYGAEREHIQT 1098
            ||...|.:    :..::::|:      :...|.:...:.||..:.:    :..:..|.|:...:.
  Fly   587 RINNDNKELPDPEKLNIATYQ------EVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSEN 645

  Fly  1099 MPIL-------------APPVPEPSV--TPLEVSRTSSTIE---ISFRQGYFSNAHGMVRSYTII 1145
            ..|:             .|.:.:|.:  .|.:.|.::|..|   :|.:......|:  :..:.:.
  Fly   646 NDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGAN--LTEHALK 708

  Fly  1146 IAE----DVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANC 1206
            |.|    |.....:..|.|               .:...||.:..:.|.:...:      |..:.
  Fly   709 ILESKLRDKRNAVTSDENP---------------ILSAVNPNVPLHDSSRDVFD------GEIDI 752

  Fly  1207 DKHQAGYC-------NGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPI-TTERSDTVI-VAATVSA 1262
            :.:..|:.       |..|.|.:.|         .|..|....:.|| :....|..: :.....|
  Fly   753 NSNYTGFLEIIVRDRNNALMAYSKY---------FDIITPATEAEPIQSLNNMDYYLSIGVKAGA 808

  Fly  1263 VLL-VAMVLVVVYCQH--RCQLIRRASKLARMQDELAALPEG--------YITPNR-------PV 1309
            ||| |.:|.:|::..|  :.:...:......::|.|:....|        :||...       |:
  Fly   809 VLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPI 873

  Fly  1310 HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP 1374
            |..|....|:....|:|:.|..|:|.|.:...|:....::|..|..|||:.:|..||.:|.||..
  Fly   874 HRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAV 938

  Fly  1375 VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439
            ::....:||||||::.|:...::||..|||:.||.::||||.||.:...|||||...|..:.||.
  Fly   939 INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCA 1003

  Fly  1440 QYWPVDRV--AMFYGDIKVQLIIDTHYHDWSISEFMVSRNC-------ESRIMRHFHFTTWPDFG 1495
            :||| ::|  ...:|||.|:...:....|:......||:|.       :.|.:..:|:.||.||.
  Fly  1004 KYWP-EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFM 1067

  Fly  1496 VPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAM 1560
            .||.|..:::|:|....|......||:|||||||||:||.:|||.::|.:.:.|.|.|:..|..:
  Fly  1068 APEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDL 1132

  Fly  1561 RKERVFMVQTEQQYVCIHQCLLAV-LEGKEHLLAD-------SLELHANDGYEVTKIYLERQPQT 1617
            |.:|.|:||:.:||:.:::.||.. ..|...:..|       ||:...|:|    |..||
  Fly  1133 RHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEG----KCKLE----- 1188

  Fly  1618 KMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQ 1654
                :.....||.|:::.......::|:.:.:.:.|:
  Fly  1189 ----VEFEKLLATADEISKSCSVGENEENNMKNRSQE 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020	12/73 (16%)
		FN3	620..706	CDD:238020	20/88 (23%)
		fn3	708..796	CDD:278470	16/100 (16%)
		fn3	824..886	CDD:278470	21/85 (25%)
		fn3	902..978	CDD:278470	14/85 (16%)
		fn3	1013..1092	CDD:278470	16/96 (17%)
		UP_III_II	1106..>1248	CDD:297589	25/158 (16%)
		PTPc	1329..1582	CDD:214550	96/261 (37%)
		PTPc	1355..1582	CDD:238006	89/235 (38%)
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	23/111 (21%)
		Ig	150..221	CDD:143165	19/88 (22%)
		fn3	237..321	CDD:278470	15/95 (16%)
		FN3	339..432	CDD:238020	20/92 (22%)
		FN3	439..535	CDD:238020	17/116 (15%)
		PTPc	892..1155	CDD:214550	97/263 (37%)
		PTPc	920..1155	CDD:238006	90/235 (38%)
		PHA02694	<1121..1206	CDD:177476	25/97 (26%)
		PTPc	1186..1449	CDD:214550	7/45 (16%)
		PTPc	1216..1449	CDD:238006	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443524
Domainoid	1	1.000	156	1.000	Domainoid score	I1041
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940