Protein Alignment Ptp4E and Ptpmeg

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_612031.3
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Alignment Length: 1036
• Identity: 230/1036 - (22%)
• Similarity: 351/1036 - (33%)
• Gaps: 333/1036 - (32%)

  Fly   726 LEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDL-------SPGR----- 778
            |.:|:..|.|    ::|    .:.:.:||.  |...:|..:..:|:.:.       .|.|
  Fly    77 LLFPQKPGDV----VRW----VDAQKQFKK--QCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEF 131

  Fly   779 -QYRFEVQASSNGIRSGTTHLSTRTMPL-----IQSDVFIANA-GHEQGQ--------DETITLS 828
             :|:|.:|...| |..|....|:.|..|     :||::...|| .|:.|.        |:|
  Fly   132 TRYQFYLQIKRN-ILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQT---- 191

  Fly   829 YTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTE-------RKLSFSGL-------TPGKLYNVT 879
               |.|:....::::...|        :|..|.|       ::|...|:       :.||...:.
  Fly   192 ---TEAERKVGELHKLHRG--------QLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLG 245

  Fly   880 VWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQY-LSADEEAPQ 943
            |    ..|..|..|...|::....|.:..:....::..:.......|..|..|.: :|:.:.|..
  Fly   246 V----SAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKA 306

  Fly   944 LLQN-VTKNTEITLQGLRPYHNYTF------------------------------TVVVRS---- 973
            |.:: |..::...|:  ||:....|                              .|.|||
  Fly   307 LWKSCVEHHSFFRLK--RPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKR 369

  Fly   974 --GSIQGTDFADVSVSTLMRS-SAPISASYQTLTAPPGKVDYFQPSDVQPGEV-TFEWSLEPAEQ 1034
              |:..|...:..|..|.|:. |...||:......|.|           .|.: |...:..|.:.
  Fly   370 LLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAG-----------AGTILTITKTSRPHDN 423

  Fly  1035 HGPIDYFRITCQNADD----AADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREH 1095
                   ::|.:.||.    |.:..|.|:.:....|.|:....      |.::.|..........
  Fly   424 -------KVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTR------RFESASPSPMPPAYSS 475

  Fly  1096 IQTMPILAPPVPEPSVTPLEVSRTSSTIEISFR---QGYFSNAHGMVRSYTIIIAEDVGKNASG- 1156
            .|..|||.|.....:|...:....|..|.|..:   ||.:                  |.|..|
  Fly   476 GQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRY------------------GFNVKGG 522

  Fly  1157 --LEMPSWQDVQAYTVWLPYQAIEPYNP-------FLTSNGSRKSSLEAEHFTIGTANCDKHQAG 1212
              |.:|    ||...| :|:...:...|       .|..||.....|..|.......:| :|||
  Fly   523 VDLSLP----VQVSKV-VPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDC-RHQA- 580

  Fly  1213 YCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQH 1277
              :|.|                                                   |:.|..|.
  Fly   581 --SGEL---------------------------------------------------LLTVRPQR 592

  Fly  1278 RCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFS------------ 1330
            ...|:.....|.:.      :||.          .:...|..::..|:.|..|
  Fly   593 SAPLLLEEEPLYQY------VPES----------DEIGSHSNLLDGDALFTQSLLLLSDGLASGA 641

  Fly  1331 --EEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANY----M 1389
              .::|.:.....|.|.:.|..|.|.||||:.:|.|||.:|..|  |:...| |||||||    :
  Fly   642 LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL--VNSLTG-DYINANYVNMEI 703

  Fly  1390 PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV--DRVAMFYG 1452
            || .:...:|.|||||.||..:||||..:.:|..:||||...|.||:||.|||||  :.:.:..|
  Fly   704 PG-GAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG 767

  Fly  1453 DIKVQLIIDTHYHDWS--ISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRF---VRAFR- 1511
             ..|:.:.:......|  ..||::....|.|.:.|..:..|||..||..|...:.|   |||.|
  Fly   768 -FSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARN 831

  Fly  1512 -----------------------DVIGTDMR-------------------------------PII 1522
                                   |..|..||                               |:|
  Fly   832 RTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVI 896

  Fly  1523 VHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA 1583
            ||||||:||:|..|.:|..|..:...:.|....||..||.:|..|||...||..:.:|:.|
  Fly   897 VHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICA 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	5/22 (23%)
		fn3	708..796	CDD:394996	18/82 (22%)
		fn3	902..978	CDD:394996	17/113 (15%)
		fn3	1013..1092	CDD:394996	13/83 (16%)
		PTP_tm	1127..1247	CDD:465889	23/132 (17%)
		R3-PTPc	1358..1579	CDD:350396	93/286 (33%)
Ptpmeg	NP_612031.3	B41	35..232	CDD:214604	37/180 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	16/97 (16%)
		FA	333..369	CDD:462582	4/35 (11%)
		PDZ_PTPN3-4-like	500..589	CDD:467190	27/166 (16%)
		PTPc-N3_4	692..961	CDD:350389	86/268 (32%)