Protein Alignment Ptp4E and Epha2

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001102447.1
• Gene: Epha2 / 366492
• RGDID: 1307204
• Length: 977
• Species: Rattus norvegicus
• Alignment Length: 759
• Identity: 153/759 - (20%)
• Similarity: 247/759 - (32%)
• Gaps: 244/759 - (32%)

  Fly   906 LKAIQVAAREITLHWTAP---------------------AGEYTDFE--LQYLSADEEAPQLLQN 947
            |.||.:.|: :.|.||||                     :||....|  :||    .|.||.|
  Rat   336 LTAIGMGAK-VELRWTAPQDTGGRKDIVYSVTCEQCWPESGECGSCEASVQY----SEPPQAL-- 393

  Fly   948 VTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDY 1012
              ..|.:|:..|.|:.||||||..|:|           ||.|:.|.:..:||.......|.||
  Rat   394 --TRTSVTVSDLEPHMNYTFTVEARNG-----------VSDLVNSRSFRTASVSINQTEPPKV-- 443

  Fly  1013 FQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQG---KIDGLVPG 1074
             :..|.....::..||: |..|...:..:.:|.:...||   :||.  |:.|.|   .:|||.||
  Rat   444 -RLEDRSTTSLSVAWSI-PVPQQSRVWKYEVTYRKKGDA---NSYN--VHRTDGFSVTLDGLAPG 501

  Fly  1075 NHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMV 1139
            ..|:.::||.:..|.||           ...|.|......|.|.|.:.|.        ..|.|:|
  Rat   502 TTYLVQVQALTQEGQGA-----------GSKVHEFQTLSTEGSATMAVIG--------GVAVGVV 547

  Fly  1140 RSYTIIIAEDVG-------KNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAE 1197
               .:::...:|       :|....:  |.:||.       :...|...|..|
  Rat   548 ---LLLVLAGIGFFIHRRRRNLRARQ--SSEDVY-------FSKSEQLKPLKT------------ 588

  Fly  1198 HFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTER-----------S 1251
                   ..|.|             ||....:|..   |||..::.|.::.::           .
  Rat   589 -------YVDPH-------------TYEDPNQAVL---KFTTEIHPSCVSRQKVIGAGEFGEVYK 630

  Fly  1252 DTVIVAATVSAVLLVAMVLVVVYCQ-HRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFS 1315
            .|:..::....:.:....|...|.: .|...:..||.:.:.........||.::..:|:.:  .:
  Rat   631 GTLKSSSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMI--IT 693

  Fly  1316 EHYRIMSADSDFRFSE-EFEELKHVG-------------------RDQACSFANLPCNRPKNRFT 1360
            |:....:.|...|..: ||..|:.||                   ||.|.  .|:..|  .|...
  Rat   694 EYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAA--RNILVN--SNLVC 754

  Fly  1361 NILPYDHSRFKLQPVDDDDGSDYINAN-------YMPGHNSPREFIVTQGPLHSTREEFWRMCWE 1418
            .:..:..||.    ::||..:.|..:.       ..|...|.|:|        ::..:.|
  Rat   755 KVSDFGLSRV----LEDDPEATYTTSGGKIPIRWTAPEAISYRKF--------TSASDVW----- 802

  Fly  1419 SNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR------- 1476
              |..|||               |.|    |.||:...          |.:|...|.:
  Rat   803 --SYGIVM---------------WEV----MTYGERPY----------WELSNHEVMKAINDGFR 836

  Fly  1477 -----NCESRIMRHFHFTTW-------PDFG-VPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAG 1528
                 :|.|.|.: .....|       |.|. :......|:|...:.:.:...|.| :.:...:.
  Rat   837 LPTPMDCPSAIYQ-LMMQCWQQERSRRPKFADIVSILDKLIRAPDSLKTLADFDPR-VSIRLPST 899

  Fly  1529 VGRSGT-FIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTE 1571
            .|..|. |..:...|:.|....|.:.|.:......|:|..:..:
  Rat   900 SGSEGVPFRTVSEWLESIKMQQYTEHFMVAGYTAIEKVVQMSND 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996	30/94 (32%)
		fn3	1013..1092	CDD:394996	23/81 (28%)
		PTP_tm	1127..1247	CDD:465889	20/126 (16%)
		R3-PTPc	1358..1579	CDD:350396	41/242 (17%)
Epha2	NP_001102447.1	EphR_LBD_A2	27..200	CDD:198448
		fn3	331..419	CDD:394996	30/102 (29%)
		fn3	439..520	CDD:394996	27/100 (27%)
		EphA2_TM	<570..611	CDD:464211	14/84 (17%)
		Protein Kinases, catalytic domain	608..876	CDD:473864	52/322 (16%)
		SAM_EPH-A2	903..972	CDD:188942	8/41 (20%)