Protein Alignment Ptp4E and Ptprt

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_063140269.1
• Gene: Ptprt / 362263
• RGDID: 1309653
• Length: 1487
• Species: Rattus norvegicus
• Alignment Length: 1330
• Identity: 316/1330 - (23%)
• Similarity: 488/1330 - (36%)
• Gaps: 419/1330 - (31%)

  Fly   591 HPGSGYEVKVHAISHGVRSEPHSY-FQAVFPKPPQNLTLQTV-------HTNLVVLHWQAPEGSD 647
            |||.....:|..::|..|..||.. .|.|.....||.|.|.:       |..|.:..|...:.:.
  Rat   177 HPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 241

  Fly   648 FSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTV-----SFGVESPHPLELNVTM 707
            ....||.:|       |.|      |.:......:|.:.:...|     ..||.  :..||.|..
  Rat   242 MVTRVVNHR-------RFS------ATVSVADTSQRSVSKYRCVIRSDGGSGVS--NYAELIVKE 291

  Fly   708 PPQPVSNVVPLVDSRNLTLEWPRP-------DGHVDFYTLKWWPTDEEDRVEFKNVT----QLED 761
            ||.|::  .|.:.:...|..|.:|       ||.:   .||        .||::..|    :...
  Rat   292 PPTPIA--PPELLAVGATYLWIKPNANSIIGDGPI---ILK--------EVEYRTTTGTWAETHI 343

  Fly   762 LSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT 826
            :.||:.:  :..|.|..:|...|..:..| ..||.
  Rat   344 VDSPNYK--LWHLDPDVEYEIRVLLTRPG-EGGTG------------------------------ 375

  Fly   827 LSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLP 891
               .|.|..:|     |....||                                 |.|.
  Rat   376 ---PPGPPLTT-----RTKCADP---------------------------------VHGP----- 394

  Fly   892 VQRLYRLHPLPISDLKAIQVAAREITLHWTAPAG---------------EYTDFELQYLSADEEA 941
                        .:::.:.:.||::||.| .|.|               :|...:.||     ||
  Rat   395 ------------QNVEIVDIRARQLTLQW-EPFGYAVTRCHSYNLTVQYQYVFNQQQY-----EA 441

  Fly   942 PQLLQNVTKNTEITLQGLRPYHNYTFTVVVRS--GSIQGTDFADVSVSTLMRSSAPISASYQTLT 1004
            .:::|.   ::..||:||||:......:::.:  |.::..:..                 .||..
  Rat   442 EEVIQT---SSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-----------------VQTEE 486

  Fly  1005 APPGKVDYFQPSDVQPG----EVTFEWSLEPAEQHGPIDYFRITCQ---NADDAADVSSYEFPV- 1061
            ..||.|..   ..:|.|    ::..:|. .|.|.:|.|..:.|..:   :.|.:||:||....|
  Rat   487 DVPGAVPL---ESIQGGPFEEKIYIQWK-PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVF 547

  Fly  1062 ---NATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPE-PSVTPLEVSRTSST 1122
               |.|.....||.||..|.|.|:|.:|.|:|..........|.||.:|| .:.:||  :.|.:|
  Rat   548 KLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADSPL--NETDTT 610

  Fly  1123 IEISFRQGYFSNAHGMVRSYTIIIAED-VGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTS 1186
            |.:..:......|  .|..|.:::.|: :.|:....::     ::.::|.:.|:
  Rat   611 ITVMLKPAQSRGA--PVSVYQLVVKEERLQKSRRAADI-----IECFSVPVSYR----------- 657

  Fly  1187 NGSRKSSLE-------------AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFT 1238
            |.|...||.             .:.||:|.   :|...||.|.||....:|.|..:|.:..:..|
  Rat   658 NASNLDSLHYFAAELKPSNLPVTQPFTVGD---NKTYNGYWNPPLSPLKSYSIYFQALSKANGET 719

  Fly  1239 -------------------------------DTVYSSPITTER--SDTVIVAATVSAVLLVAMVL 1270
                                           .|..|:.:..|:  .:||.:|..::.:|:..::|
  Rat   720 KINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 784

  Fly  1271 VVV------------YCQHRCQLIRRASKLARMQDELAA-------------LPEGYITPNR--- 1307
            :.|            |..:..|     .|||:.|.|..:             .|...::.||
  Rat   785 LGVMLTIKRRRNAYSYSYYLSQ-----RKLAKKQKETQSGAQREMGPVASTDKPTTKLSTNRNDE 844

  Fly  1308 -------------------------------------------------PVHVKDFSEHYRIMSA 1323
                                                             .:.|.|..:|...|..
  Rat   845 GFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKR 909

  Fly  1324 DSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANY 1388
            ...:.|.||:|.|.. |:..:...|....||.|||:.||:.|||||.:|..:|.|..||||||||
  Rat   910 GQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 973

  Fly  1389 MPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGRE----------------- 1436
            :.|::.||.:|.||||:..|.::||||.|:.||.:|||:|...|.||.
  Rat   974 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGTATLGRAASP 1038

  Fly  1437 ---KCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGV 1496
               ||.:|||.|  ...||||||.||......::.|..|.|.:.  .|.|.:|.||||:|||.||
  Rat  1039 GMVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV 1101

  Fly  1497 PEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMR 1561
            |.....|:.|||..:.:...:..||:||||||.||:|.|||:|.:|........||||..|..:|
  Rat  1102 PCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1166

  Fly  1562 KERVFMVQTEQQYVCIHQCLL-AVLEGKEHL-LADSLELHANDGYEVTKIYLERQPQTKMGTLPI 1624
            .:||.:||||:|||.:|..:| |.|.|...: :.:...|:    |.::::    .|||....:
  Rat  1167 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY----YNISRL----DPQTNSSQI-- 1221

  Fly  1625 RASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLAT-EVKPKGSNDDEEDEEDDDDDDDDQQPLN 1688
                             |||        .|.|.:.| .|:|:..:........|.:...|..||
  Rat  1222 -----------------KDE--------FQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPL- 1260

  Fly  1689 NETTATLSSASCSSSTHDVHVVLQEAIEKP 1718
            :.....|.|....||.: ::..|.::.::|
  Rat  1261 DRCLPFLISVDGESSNY-INAALMDSHKQP 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	41/177 (23%)
		fn3	708..796	CDD:394996	22/98 (22%)
		fn3	902..978	CDD:394996	20/92 (22%)
		fn3	1013..1092	CDD:394996	27/89 (30%)
		PTP_tm	1127..1247	CDD:465889	26/164 (16%)
		R3-PTPc	1358..1579	CDD:350396	107/242 (44%)
Ptprt	XP_063140269.1	None