DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and Ptprf

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:XP_038966082.1 Gene:Ptprf / 360406 RGDID:3453 Length:1924 Species:Rattus norvegicus


Alignment Length:1809 Identity:414/1809 - (22%)
Similarity:631/1809 - (34%) Gaps:616/1809 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 SSNANAFYRI-DYSPPFGFPEP--------NTTIPASDIGKDIKFSRALPGTE------------ 125
            |:.||.:.|: ..:|.|..|..        |..:....:|..:.:.:.:.|.|            
  Rat   224 SAPANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGR 288

  Fly   126 -----------YNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGR- 178
                       .|:.....:|....:.|..|.:...|.||.:|.|...::.|..:||   .||. 
  Rat   289 NVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTW---DSGNT 350

  Fly   179 ----YSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQVQAY---SVYQGKESVAYT 236
                :.|.:.|..| ||.||:   .::|..:.:.|...|:|...|..:..   |:.:|..|.|..
  Rat   351 EPVSFYGIQYRAAG-TDGPFQ---EVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVR 411

  Fly   237 SRNFTTKPNTPGKFI-VWFRNETTLLVLWQPP-FPAGIYTHYRVSITPD-------------DA- 285
            :|.....|::|.:.: ....:.:|:||.|:|| .|.|:...|||..|||             || 
  Rat   412 ARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAG 476

  Fly   286 --------IQSVLYVER---------------------EGEPPGPAQAAFKG----------LVP 311
                    :..:.|..|                     :|.|..||....|.          |:|
  Rat   477 LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAKAESDTRIQLSWLLP 541

  Fly   312 GREYNISVQTV---SEDE----------TSSV------PTTARYLTV------------------ 339
            .:|..|..:.|   :|||          |||.      |.|..:..:                  
  Rat   542 PQERIIKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEAR 606

  Fly   340 ---------PERVLNVTFDEAYTTSSSFRVRWEPP---------RTYSEFDAYQVMLSTSRRIFN 386
                     |::|..|:     |.|::.||.|.||         ..||.  ||:.:....|:...
  Rat   607 TAQSTPSAPPQKVTCVS-----TGSTTVRVSWVPPPADSRNGIITQYSV--AYEAVDGEDRKRHV 664

  Fly   387 VPRAANGDSVYFDYPDI--LEPGRTYEVVVKTIADNVNSWPASGEVTLR---------PR--PVR 438
            |...:...|.:    |:  ||....|.|.|:...| |...|.|..|.:|         ||  .|.
  Rat   665 VDGISREHSSW----DLLGLEKWTEYRVWVRAHTD-VGPGPESSPVLVRTDEDVPSGPPRKVEVE 724

  Fly   439 SLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSL 503
            .|      .|.|:|:||:                        .|.|.....||            
  Rat   725 PL------NSTAVHVSWK------------------------LPVPNKQHGQI------------ 747

  Fly   504 LAGRRYLIAVQALSKGVASNASDITRYTRP-AAPLIQELRSIDQGLMLS---WRSDVNSRQDRYE 564
               |.|.:....|..|            .| ..|:||:       :||:   ||.:   ..:.||
  Rat   748 ---RGYQVTYVRLENG------------EPRGQPIIQD-------VMLAEAQWRPE---ESEDYE 787

  Fly   565 VHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAIS---HGVRSEPH--SYFQAVFPKPPQ 624
            .                    ||..|.|.:.|.:.|.|.:   .|.||:|.  :...||..:|..
  Rat   788 T--------------------TISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTM 832

  Fly   625 NLTLQTVHTNLVVLHWQAPE--GSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQ 687
            .::...:||.|  |.|..|:  ..:...|.::||            ..:|||             
  Rat   833 MVSTTAMHTAL--LQWHPPKELPGELLGYRLQYR------------RADEAR------------- 870

  Fly   688 VNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVE 752
            .||:.||.:..|                                                     
  Rat   871 PNTIDFGKDDQH----------------------------------------------------- 882

  Fly   753 FKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGH 817
                            ..:..|..|..|.|.:.|.:                         .||.
  Rat   883 ----------------FTVTGLHKGATYIFRLAAKN-------------------------RAGP 906

  Fly   818 EQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWT 882
            .:..::.||   ||..|.|          |.|             :.|..:|||           
  Rat   907 GEEFEKEIT---TPEDAPS----------GFP-------------QNLRVTGLT----------- 934

  Fly   883 VSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPA-----GEYTDFELQYLSADEEAP 942
                                          .....|.|..|.     |..|::.:.|  .|..:.
  Rat   935 ------------------------------TSTTELAWDPPVLAERNGRITNYTVVY--RDINSQ 967

  Fly   943 QLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPP 1007
            ..|||||.:..:||.||:|  :.|:.:.||:.:.:|              :.|:|.|.|:.|.|.
  Rat   968 HELQNVTGDVHLTLLGLKP--DTTYDIKVRAHTSKG--------------AGPLSPSIQSQTMPM 1016

  Fly  1008 GKV--DYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDG 1070
            .:|  ..|:.:......|...|.:                  .|.......::...|....::||
  Rat  1017 EQVFAKNFRVAAAMKTSVLLSWEV------------------PDSYKSAVPFKILYNGQSVEVDG 1063

  Fly  1071 ---------LVPGNHYIFRIQAKSALGYGAER-EHIQTMPILAPPVPEPSVTPLEVSRTSSTIEI 1125
                     |.|...|.|.:..:.:...|.:. ..|:|.|.|.|..|.|:...:|..|.|    :
  Rat  1064 HSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFS----L 1124

  Fly  1126 SFRQGYFSNAHGMVRSYTIIIA--EDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNG 1188
            |..|   .....:||.:.|::.  :.||.|   |..|.|...:...:....:|||.     ....
  Rat  1125 SMPQ---VQDPSLVRWFYIVVVPIDRVGGN---LLAPRWSTPEELELDELLEAIEQ-----GEEK 1178

  Fly  1189 SRKSSLEAEH---------------FTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAF----TDE 1234
            .|:...:||.               ||:|.   .|:..|:.|.||....:|:..:.|.    .|:
  Rat  1179 QRRRRRQAERLKPYVAAQVDELPETFTLGD---KKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQ 1240

  Fly  1235 DKFTDTVYSSPITT--------ERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK---- 1287
            .::..:.||..|..        |..:.:.|...|.||:|:.::::.:....|.:....:||    
  Rat  1241 KRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQS 1305

  Fly  1288 -------LARMQDELAALPEGYITP---------------NRPVHVKDFSEHYRIMSADSDFRFS 1330
                   ||...|.:......|.||               :.|:.:.|.:::...:.|:...:||
  Rat  1306 IGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFS 1370

  Fly  1331 EEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSP 1395
            :|:|.: ..|:......:|...|:||||:.|::.|||||..|..:|...|||||||||:.|:...
  Rat  1371 QEYESI-DPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQ 1434

  Fly  1396 REFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLII 1460
            ..:|.|||||..|..:||||.||..:..:||:||..||.|.|||||||. |....||.|:|.|:.
  Rat  1435 NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETYGLIQVTLVD 1498

  Fly  1461 DTHYHDWSISEFMV--SRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIV 1523
            ......:::..|.:  |.:.|.|.:|.|.|..|||.||||.|..::.|:|..:.....|..|::|
  Rat  1499 TVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVV 1563

  Fly  1524 HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEG 1587
            ||||||||:|.||.:|.:|:.:.....|||:|.|..||.:|.:|||||.|||.||:.|| |.:.|
  Rat  1564 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCG 1628

  Fly  1588 KEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTN 1641
            ...:||.:|..|..                |:|.:|...|:. |.:|:..|:.|
  Rat  1629 HTEVLARNLYAHIQ----------------KLGQVPPGESVT-AMELEFKLLAN 1665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 75/352 (21%)
fn3 247..328 CDD:394996 32/148 (22%)
FN3 319..>749 CDD:442628 96/508 (19%)
fn3 708..796 CDD:394996 5/87 (6%)
fn3 902..978 CDD:394996 20/80 (25%)
fn3 1013..1092 CDD:394996 12/87 (14%)
PTP_tm 1127..1247 CDD:465889 29/140 (21%)
R3-PTPc 1358..1579 CDD:350396 102/222 (46%)
PtprfXP_038966082.1 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 136..232 CDD:409400 3/7 (43%)
Ig strand A 136..138 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 196..201 CDD:409400
Ig strand F 210..217 CDD:409400
Ig strand G 220..231 CDD:409400 3/6 (50%)
IgI_3_RPTP_IIa_LAR_like 241..322 CDD:409401 9/80 (11%)
Ig strand A 241..243 CDD:409401 0/1 (0%)
Ig strand A' 247..251 CDD:409401 0/3 (0%)
Ig strand B 254..262 CDD:409401 1/7 (14%)
Ig strand C 267..273 CDD:409401 0/5 (0%)
Ig strand C' 275..277 CDD:409401 0/1 (0%)
Ig strand D 280..284 CDD:409401 0/3 (0%)
Ig strand E 289..294 CDD:409401 0/4 (0%)
FN3 294..718 CDD:442628 98/442 (22%)
Ig strand F 301..308 CDD:409401 1/6 (17%)
Ig strand G 312..321 CDD:409401 2/8 (25%)
FN3 598..1065 CDD:442628 141/789 (18%)
PTP_DSP_cys 1352..1627 CDD:475123 118/276 (43%)
R-PTP-F-2 1629..1919 CDD:350477 12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

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