Protein Alignment Ptp4E and clr-1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001022209.1
• Gene: clr-1 / 3565419
• WormBaseID: WBGene00000548
• Length: 1444
• Species: Caenorhabditis elegans
• Alignment Length: 1483
• Identity: 320/1483 - (21%)
• Similarity: 520/1483 - (35%)
• Gaps: 475/1483 - (32%)

  Fly   457 PAETGRQDSYR-----------ISYHEQTNASEVPAPF-------PVAAESQITTNLTEYTLDSL 503
            ||.|.:|..|.           ..|..:.:..| |..:       |...:..:|.|.....|:|.
 Worm    93 PAITPKQCGYNYRTPSTCLLMDADYRSKYDVKE-PTCYSRKCVCPPQFDDVHVTANQKPLRLNST 156

  Fly   504 L----AGRRYLIAV------QALSKGVASNASDITRYTRPAAPLIQELRSID-QGLMLSWRSDVN 557
            |    ..:|.|..|      .::|||:     |:|.:.         ..::| :|.:     ||.
 Worm   157 LLPTKCDKRDLAVVARAHPSTSVSKGI-----DVTLFC---------CINVDPEGFI-----DVA 202

  Fly   558 SRQDRYEVHYQRNGT--REERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFP 620
            |      |.:.:|||  ||          .|.|...|.:|...:||        |.:|.::
 Worm   203 S------VFFIQNGTIMRE----------ATSHPFAPRNGLARRVH--------EKYSCWE---- 239

  Fly   621 KPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYL 685
                 |.::...|            ||...|:.|....||                |:...:...
 Worm   240 -----LEIKNAQT------------SDSGSYMCRVTASAS----------------DLDVTDTMQ 271

  Fly   686 VQV-----NTVSFGVESPHPLELNVTMPPQPVSNVVPLVDS--------RNLTLE---------W 728
            .:|     .|.|:..:.|..:     |||...|::....|.        :|||:.         |
 Worm   272 FEVKEHARRTHSYWYKRPKKV-----MPPSSSSSLKTSDDDDDSTPRQIKNLTVNPSERDAIVTW 331

  Fly   729 PRPDGH---VDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNG 790
            ....|.   :|...::  .||...:|.|..    ::|:||   :.|:||.....|...|..::..
 Worm   332 ESEGGEDMAIDLRLVR--RTDTRGQVVFSK----DNLTSP---VSIKDLRAATPYTLFVSGNNGQ 387

  Fly   791 IR-SGTTHLST---RTMPLIQSDVFIANAGHEQGQDETITLSYT---PTPADS----TRFDI--- 841
            :. ..|.|.:|   |..|..:.||.:.|:|.        .||..   .:||:.    |::.:
 Worm   388 VPFEFTEHFTTKQKRPFPPKEEDVRVLNSGS--------ALSCEVEWKSPAEPNGRITKYFVSVR 444

  Fly   842 --YRFSMGDPTIKD-------KEKLAN-DTERKLS------------------FSGLTPGKLYNV 878
              .|.|.|..|..|       .::.|| |.:...|                  |..|.|.:.|.|
 Worm   445 GAMRKSDGSLTPDDLPAAVEVDKRCANWDGDENTSKHNGINPIDFANEFYSCKFGPLKPNRNYTV 509

  Fly   879 TVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAP----------AGEYTDFELQ 933
            |||..:....|||.                  |..:....::..|          :..::.|.|.
 Worm   510 TVWAENSAGRSLPA------------------VFHKNCVTNYAQPDMVETPQPLLSNNHSTFSLT 556

  Fly   934 YLSADEEAPQLLQNVTKNTEITLQGLRPY-HNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPIS 997
            :       ||...::..........:.|. .|.:..::.:|..|....|:.|..:.|:.|||...
 Worm   557 F-------PQPPDDINGPISCYYIAIVPLPANVSLDILPKSEEIVMHSFSKVFTNNLLPSSAEEK 614

  Fly   998 ASYQTLTAPPGKVDYFQPSDVQ-PGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPV 1061
            ..:.          |...|.|| |.|.|..            |..|::...|.:...:|.|....
 Worm   615 RFFA----------YIAESYVQLPEETTIG------------DGVRVSDLKACNVQYLSRYSSED 657

  Fly  1062 NATQGKIDGLVPGNHYIFRIQAKSALG-----YGAEREHIQTMPILAPPVPEPSVTPLEVSRTSS 1121
            .|.:   .||......|.|:..:..|.     .||:       |.:...:.:.||:|...:||:|
 Worm   658 LALR---RGLKYTGFLIVRVDKEEELNRKDVRNGAD-------PNIFRNLIDKSVSPTSRTRTAS 712

  Fly  1122 TIEISFRQGYFSN-AHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLT 1185
            .:....||.:.|. |:| ..:|...|..|...::||           :.:::  :.|.|:..||.
 Worm   713 PMSRHLRQLHLSGPAYG-YSAYFKPILLDTESSSSG-----------FGIFM--KIILPFLLFLA 763

  Fly  1186 SNGSRKSSLEAEHFTIGTANCDKHQ-AGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTE 1249
            .         |...|:...|...|. :.:|                              |:.|:
 Worm   764 F---------ATGVTMFFVNRKGHMLSTWC------------------------------PLFTK 789

  Fly  1250 RSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDF 1314
            .:...:|..|:                              ::....|:|           |.|.
 Worm   790 MTSKDVVERTL------------------------------LKQTFGAIP-----------VDDL 813

  Fly  1315 SEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDD 1379
            ...|.:...|:||.|::|:|.|.|...|...|  |...|..|||:.:|..:|.:|.||:.::.||
 Worm   814 PTEYVVRHRDTDFLFAQEYESLPHFQLDTVAS--NRKENAIKNRYNDIRAFDDTRVKLKKINGDD 876

  Fly  1380 GSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV 1444
            .|||||||::......:.||..|.|:.:|..:||||.||..|..|||:....||.|::|.:|||.
 Worm   877 YSDYINANFIKSWKEKKLFIAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPD 941

  Fly  1445 DRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NC-------------------------ESRI 1482
            :::.. ||||.|:....:.:.|::|..|.::.  .|                         .||.
 Worm   942 EQITR-YGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANVPIVKGQFANNSRR 1005

  Fly  1483 MRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK 1547
            :..:|||.|.|:..||....|:||:...|::...:..|:::||||||||:||||::|.:|.....
 Worm  1006 ILQYHFTNWNDYKAPECSTGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLA 1070

  Fly  1548 SDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLE--LHANDGYE----- 1605
            .|..:||..|..:|::|..|||:.:|||.|::.|     .:.|:..|:.|  ....|.|:
 Worm  1071 EDKANIFEFVCNLRRQRNLMVQSLEQYVFIYKAL-----AEWHMYGDTDEDVRDFEDHYQRLCAS 1130

  Fly  1606 --VTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPKGSN 1668
              ...:...:|..|. |::..|.::..:.:   .:.|:..|...:|:.::.:..|.|   |..||
 Worm  1131 NRDRAVSFNQQSSTN-GSISPRVAIVSSRE---SMTTSNGETGLEEEFKKLERNLTT---PLSSN 1188

  Fly  1669 DDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEKPKQEQERICAGTQSHA 1733
            ...:||          ..|.|...|.:                      |..:...|...|..||
 Worm  1189 FAAKDE----------NLLKNRYEAAV----------------------PFDKYRVILPPTIGHA 1221

  Fly  1734 DTESDNTD-----------SDDDDEDG----------DGKVAKDGAVADEDGW 1765
            |:...|..           :.|...:|          |..|.....::||..|
 Worm  1222 DSSYINASHIKGYFFDYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLSDETDW 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	67/347 (19%)
		fn3	708..796	CDD:394996	22/108 (20%)
		fn3	902..978	CDD:394996	10/86 (12%)
		fn3	1013..1092	CDD:394996	18/84 (21%)
		PTP_tm	1127..1247	CDD:465889	20/121 (17%)
		R3-PTPc	1358..1579	CDD:350396	87/247 (35%)
clr-1	NP_001022209.1	FN3	403..523	CDD:238020	29/127 (23%)
		PTPc	827..1106	CDD:214550	99/286 (35%)
		PTPc	1169..1437	CDD:214550	25/141 (18%)