DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and Ptp36E

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	103/335 - (30%)
Similarity:	163/335 - (48%)	Gaps:	35/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1305 PNRPVHVKDFSEHYRIMSADSDFR------FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNIL 1363
            ||.|:.::.|.:.       .|.|      :..||:....| ....|..|....|..||:....:
  Fly    79 PNGPIDIRHFLKL-------CDLRRKFPVLYKLEFQTAAKV-ESNTCRHALKKNNLEKNQNPKCI 135

  Fly  1364 PYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT 1428
            |||::|..|:.|.....|||:||:|:.....|..:||||||:..|.:.:|||.|:.|..||||||
  Fly   136 PYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLT 200

  Fly  1429 RCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE------SRIMRHF 1486
            :.|:..:..|.||||.: .|...||||.:.::.:....::.|..|.:.:..|      .|::..|
  Fly   201 KTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQF 265

  Fly  1487 HFTTWPDFGVPEPPQSLVRFVRAFRDVIGT------DMR-PIIVHCSAGVGRSGTFIALDRILQH 1544
            |:|.|.....|. ..:|:.|.|..|.|:|.      ||| ||:||||.|.||||.::::|..|:.
  Fly   266 HYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLEL 329

  Fly  1545 IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKI 1609
            ..:.:..::||.:..:|:.|..:|:..:||..|:..|      :||::........::..:..|.
  Fly   330 AEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL------EEHIICGKTWFPVSELSDRLKA 388

  Fly  1610 YLERQPQTKM 1619
            ...|...|||
  Fly   389 KARRNSGTKM 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020
		fn3	708..796	CDD:278470
		fn3	824..886	CDD:278470
		fn3	902..978	CDD:278470
		fn3	1013..1092	CDD:278470
		UP_III_II	1106..>1248	CDD:297589
		PTPc	1329..1582	CDD:214550	89/266 (33%)
		PTPc	1355..1582	CDD:238006	83/240 (35%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	85/249 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940