Protein Alignment Ptp4E and Pez

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 1476
• Identity: 275/1476 - (18%)
• Similarity: 475/1476 - (32%)
• Gaps: 497/1476 - (33%)

  Fly   224 YSVYQG-KESVAYTSRNFTTKPNTPGKFIVWFRNETTLL------VLWQPPFPAGIYTHYRVSIT 281
            |..||| |:|..|..::.....|..|     ..|:.::|      ||.|   .||| .|...|..
  Fly   156 YDSYQGDKQSKDYLKKSLVLPRNMQG-----LANDDSMLEGLIVEVLQQ---QAGI-AHLSQSQA 211

  Fly   282 PDDAIQSVLYVEREGEPPGPAQ----------AAFKGLV----PGREYNISVQTVSEDETSSVPT 332
            .:..||....:|..||....|:          .|..|:|    .||:|      ....|..:|..
  Fly   212 EEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGRQY------FPWKEFHTVTI 270

  Fly   333 TARYLTVPERVL--------NVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPR 389
            ..|.:.:.:..|        :..|.||.|.    |..|:  .|.|:...::..:.|:.
  Fly   271 DKRTIKIEQNKLDGGGSIVGSFIFSEADTA----RYFWK--LTISQHKFFKRYIDTAT------- 322

  Fly   390 AANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHIS 454
                       |..|..|...|               ||     |..|.|:|          ::.
  Fly   323 -----------PSSLGSGADAE---------------SG-----PLGVDSVG----------YVD 346

  Fly   455 WEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKG 519
            ::..|....:..:..:.:|.:..:..   .:..:..|::|::..|..:.:.|:
  Fly   347 YDYNEAAAAEQLQQHHQQQQHMQQQQ---QIQQQQMISSNISLATSANQMLGQ------------ 396

  Fly   520 VASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMAT---- 580
             :|:..|::.         ..|.| ..|::....|:.|:..|..|        |.:..:.|
  Fly   397 -SSSCLDLSN---------NNLHS-SSGMLHHGGSNNNNNNDERE--------RLKAMLPTYRPA 442

  Fly   581 --NETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHT------NLVV 637
              .||::.:.|..|.:.:    |.::..:.:..::|:....|         .||.      ||:.
  Fly   443 PDYETAVQLKYRTPSAEF----HNVALAMAAPGNAYYAGSQP---------DVHNPGMHNENLLY 494

  Fly   638 LHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHP-- 700
            .|..|.          ||...|.|   .:.||         |:...|..|....|    .|.|
  Fly   495 GHMTAH----------RYPDVAQP---AAALH---------HHINLYQAQHQPQS----HPQPMS 533

  Fly   701 -----LELNVTM------PPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFK 754
                 |||:..|      .|.|..|.:....:.:|.:..|||
  Fly   534 PAQAYLELSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRP----------------------- 575

  Fly   755 NVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIA-NAGHE 818
                               |...|.|   |..||..:      :|.||  |.....::| .||..
  Fly   576 -------------------LQGFRNY---VSGSSPDL------VSNRT--LFNGGQYVALPAGGH 610

  Fly   819 QGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTV 883
            .|.        .||.:.:|....|::                    :|..|
  Fly   611 AGN--------IPTSSGATMLHQYQY--------------------VSHMG-------------- 633

  Fly   884 SGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNV 948
                           |..|                 :..|.|.:     :.|:..||.|.::..:
  Fly   634 ---------------HSQP-----------------YLPPHGTF-----ENLNMIEEQPSIMSQL 661

  Fly   949 TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTL----MRSSAP-----------ISA 998
            .::.            .:......:||:     ...|..||    .|||.|           :::
  Fly   662 RQSA------------MSQAAAAAAGSV-----VTQSSPTLPPSGYRSSVPPPASSPLPPPVVAS 709

  Fly   999 SYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNA 1063
            |:::.|          |:.:|...|  ..|:||..::.|:.  :.....:..||:..:.....::
  Fly   710 SHKSAT----------PAPLQRSLV--NGSIEPIYENVPLP--QRASGGSSGAANTEAMRQRASS 760

  Fly  1064 TQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFR 1128
            .| ...|:||       :.|    ...|...::.|:.:.:|| .:.::......|.:|| |:.|.
  Fly   761 IQ-SAPGVVP-------VPA----ARNASSNNVVTVTVNSPP-DDGNIKKYGADRAAST-ELLFL 811

  Fly  1129 QGYFSNAHGMVRSYTIIIAEDVG--------KNASGLEMPSWQDV---QAYTVWLPYQAIEPYNP 1182
            :...........|    .|.|:|        ::.:.|...|..|:   ...|:...:.|:.
  Fly   812 EPQAPKRTNRAAS----AAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMN---- 868

  Fly  1183 FLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPIT 1247
             |::|.|..:|      ::..:..|...:...:..|:     |.|...|....|..|...|:.:.
  Fly   869 -LSANTSASTS------SMFNSTLDTTSSSAASKDLK-----RKKRWNFLSRSKTPDKQKSATLG 921

  Fly  1248 TERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYIT-PNRPVHV 1311
            .|::.|.                    .||.    :.|:||...||:| .||..:.| .|:|..:
  Fly   922 REKATTA--------------------GQHS----KLAAKLKLAQDDL-NLPNRWSTGVNKPQPI 961

  Fly  1312 KD-FSEHYRIMSAD---SDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKL 1372
            .. :|:.......|   ||.:...|||.:...........|.|..|.|||...|.||||.:|.:|
  Fly   962 SGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRL 1026

  Fly  1373 QPVDDDDGSDYINANYMPG--HNSPREFIVTQGPLHS-TREEFWRMCWESNSRAIVMLTRCFEKG 1434
            .|. .|:...|:||:.:..  ....|.:||.|.|... |...||:..||::...:|.||...
  Fly  1027 TPC-RDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDM--- 1087

  Fly  1435 REKCDQYWPVD-RVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFH----------- 1487
                 .|.|.: ...:.:|..:|       |.::|    ..:..|.:..:|.:|
  Fly  1088 -----SYIPRNSHQRLEFGQFQV-------YQEFS----QTTDRCTTIKLRLYHVPSRRYRSVWY 1136

  Fly  1488 --FTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR----------PIIVHCSAGVGRSGTFIALDR 1540
              :..|.:...|......:.|:.....|.....:          |:::||..|.||||..:..|.
  Fly  1137 LQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADL 1201

  Fly  1541 ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586
            :|..:..::.:||..::..:|.:|..::.:..||..|:..|:..|:
  Fly  1202 LLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	33/130 (25%)
		fn3	247..328	CDD:394996	24/100 (24%)
		FN3	319..>749	CDD:442628	76/462 (16%)
		fn3	708..796	CDD:394996	13/87 (15%)
		fn3	902..978	CDD:394996	9/75 (12%)
		fn3	1013..1092	CDD:394996	14/78 (18%)
		PTP_tm	1127..1247	CDD:465889	22/130 (17%)
		R3-PTPc	1358..1579	CDD:350396	55/247 (22%)
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788	24/82 (29%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	21/103 (20%)
		PTP_DSP_cys	1036..1246	CDD:475123	47/228 (21%)