DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptp10D

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	1719	Identity:	988/1719 - (57%)
Similarity:	1239/1719 - (72%)	Gaps:	122/1719 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QKHFVWLVVGILTIFLAQHANAADLVINVP-NASSNANAFYRIDYSPPFGFPEPNTTIPASDIGK 113
            |..::| .:..|..|..:....|||.|::| |...:..|.||:|||||||:|||||||.:.:||.
  Fly    22 QHRWLW-SLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGD 85

  Fly   114 DIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGR 178
            :|:||||||||:|||||||||.||.:.|||||.||||||||:|||||:||.|:|.|.|.||..|.
  Fly    86 EIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGS 150

  Fly   179 YSGFRIRVLGLTDL--PFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFT 241
            |:.|:|:||||::.  .:.|::.:..| |.|.|.||||||.:||||||::|.|||||||||||||
  Fly   151 YTAFKIKVLGLSEASSSYNRTFQVNDN-TFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFT 214

  Fly   242 TKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAF 306
            ||||||||||||||||||||||||||:||||||||:|||.|.||..||||||:||||||||||||
  Fly   215 TKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAF 279

  Fly   307 KGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEF 371
            |||||||.|||||||:||||. |:||||:|.|||.|.||||||..:.||:||||.||.|:..|||
  Fly   280 KGLVPGRAYNISVQTMSEDEI-SLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEF 343

  Fly   372 DAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRP 436
            |.|||.::|:||...||| :|....:||:.||.|||:|:.|:|||::..|.||||:|:|||||.|
  Fly   344 DKYQVSVATTRRQSTVPR-SNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLP 407

  Fly   437 VRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHE-QTNASEVPAPFPVAAESQITTNLTEYTL 500
            ||:|....||::|.:.|:||......||.|||.||| :|...:.         |.:||:.|.:||
  Fly   408 VRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDT---------STLTTDRTRFTL 463

  Fly   501 DSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEV 565
            :|||.||.|.::|||:||.:.||.:.|...|||::|:|::|:||..||.:||:|||||:|::|||
  Fly   464 ESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEV 528

  Fly   566 HYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQT 630
            .|.||||.:.||..|.|:.|.|..|.||:|||:||.|:||.:|||||:|||||:|.||:|:|::|
  Fly   529 LYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIET 593

  Fly   631 VHTNLVVLHWQAPEGSDFSEYVVRYRTDA-SPWQRISGLHENEARIKDMHYGERYLVQVNTVSFG 694
            |.:|.|::||..||..:|:||.:|||||: ..|.|:..:...||.|.||..||:|.:||||||||
  Fly   594 VRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFG 658

  Fly   695 VESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQ- 758
            ||||.|.|:|.|:||.||||::.||||||:|||||:|:|.|:.|.|||||:|...||:.|||::
  Fly   659 VESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSEN 723

  Fly   759 --LEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQ 821
              .:|||  :||:.|.:|.||.||:|::|.:|.||.||.|.|..||||||||||.:|| |.::.:
  Fly   724 KSADDLS--TVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVAN-GEKEDE 785

  Fly   822 DETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGG 886
            .:||||||||||..|::|||||||:||..|:|||||||||:||::|:||.||:|||:||||||||
  Fly   786 RDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGG 850

  Fly   887 VASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKN 951
            |||||:||..||:|.||:.|.|..:...||:|.|..|.|||.||::.||:||.   .|.||:|..
  Fly   851 VASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADN---LLAQNMTTR 912

  Fly   952 TEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPS 1016
            .|||:..|||:.|||||||||||          :.|:::|||:|:|||:.|..|.||:|:.|.|:
  Fly   913 NEITISDLRPHRNYTFTVVVRSG----------TESSVLRSSSPLSASFTTNEAVPGRVERFHPT 967

  Fly  1017 DVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRI 1081
            ||||.|:.|||||..:|.:|.|..|.|...|.::..|....:|......|.|..|.||..|:|:|
  Fly   968 DVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKI 1032

  Fly  1082 QAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIII 1146
            |||:|:|:|.|||:.|||||||||.|...|.|.||.|:||||:|.||:.|||:.:|.||.||||:
  Fly  1033 QAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIV 1097

  Fly  1147 AEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQA 1211
            |||..|||||||||||.|||:|:||||||||:||.||        .:...|.|||||.|||.|:.
  Fly  1098 AEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPF--------ENRSVEDFTIGTENCDNHKI 1154

  Fly  1212 GYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDT-VIVAATVSAVLLVAMVLVVVYC 1275
            |||||||::|||||:|:||||..||||||.||.||.|::.:| :|||.||...:::.:::.:::.
  Fly  1155 GYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFY 1219

  Fly  1276 QHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVG 1340
            :.|....|:.:|.:|..|.: :||:..|..|||:.:|:|:||||:||||||||||||||||||||
  Fly  1220 KRRRNNCRKTTKDSRANDNM-SLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVG 1283

  Fly  1341 RDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPL 1405
            |||.|:||:|||||||||||||||||||||||||||||:|||||||||:||||||||||||||||
  Fly  1284 RDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL 1348

  Fly  1406 HSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSIS 1470
            ||||::||||||||||||||||||||||||||||||||.|.|.:||||||||::.|:||.||.::
  Fly  1349 HSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMT 1413

  Fly  1471 EFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTF 1535
            |||:.|..|.||:||||||||||||||.|||:||||||||||.||.:.|||:|||||||||||||
  Fly  1414 EFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTF 1478

  Fly  1536 IALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHA 1600
            |.||||||.|:.||||||||||:|||||||:||||||||:||||||||||||||:::..:.|:|.
  Fly  1479 ITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHD 1543

  Fly  1601 NDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPK 1665
            |:|||..::.|                               ||:.|         .:||.....
  Fly  1544 NEGYEGQQVQL-------------------------------DENGD---------VVATIEGHL 1568

  Fly  1666 GSNDDEEDEEDDDDDD------DDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEKPKQEQER 1724
            ..:|.::.|.:..||:      ||||||.:..|.           |..|:       .|......
  Fly  1569 SHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTG-----------HHTHM-------PPTTSMSS 1615

  Fly  1725 ICAGTQSHAD-----------TESDNTDS 1742
            ...|...|.:           .:|||.:|
  Fly  1616 FGGGGGGHTNVDAPDRXHSVVNQSDNNNS 1644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	55/92 (60%)
		fn3	247..328	CDD:278470	71/80 (89%)
		fn3	343..417	CDD:278470	40/73 (55%)
		fn3	443..525	CDD:278470	34/82 (41%)
		FN3	548..611	CDD:238020	36/62 (58%)
		FN3	620..706	CDD:238020	46/86 (53%)
		fn3	708..796	CDD:278470	50/90 (56%)
		fn3	824..886	CDD:278470	46/61 (75%)
		fn3	902..978	CDD:278470	39/75 (52%)
		fn3	1013..1092	CDD:278470	34/78 (44%)
		UP_III_II	1106..>1248	CDD:297589	90/141 (64%)
		PTPc	1329..1582	CDD:214550	213/252 (85%)
		PTPc	1355..1582	CDD:238006	190/226 (84%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	44/81 (54%)
		fn3	220..304	CDD:278470	72/84 (86%)
		fn3	315..391	CDD:278470	41/76 (54%)
		FN3	405..494	CDD:238020	40/97 (41%)
		FN3	511..574	CDD:238020	36/62 (58%)
		FN3	583..671	CDD:238020	46/87 (53%)
		fn3	683..753	CDD:278470	38/71 (54%)
		fn3	787..850	CDD:278470	46/62 (74%)
		fn3	866..935	CDD:278470	37/71 (52%)
		fn3	961..1043	CDD:278470	35/81 (43%)
		PTPc	1272..1525	CDD:214550	213/252 (85%)
		PTPc	1298..1525	CDD:238006	190/226 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447435
Domainoid	1	1.000	163	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E2759_KOG0791
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1609
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	1	1.010	-	-		QHG28083
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm25697
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
	14	13.790