DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and Ptprb

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_001359063.1 Gene:Ptprb / 314843 RGDID:1305922 Length:2000 Species:Rattus norvegicus


Alignment Length:1713 Identity:481/1713 - (28%)
Similarity:751/1713 - (43%) Gaps:319/1713 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 VPNASSNANAF-------YRIDYSPPFG---------FPEP----NTTIPASDIGKDIKFSRALP 122
            ||...||..::       :.::::||.|         |.:.    |||:...:....::....:|
  Rat   377 VPEKVSNLVSYNEIWMKSFAVNWTPPAGDWDHYRILLFNDSLVLLNTTVGKEETHFALEGLELIP 441

  Fly   123 GTEYNFWLYYTNSTHREQLTWTVNI--------TTAPDPPANLSVQLRSSKSAFITWRPPGSGRY 179
            |.:|..          |.:..:.|:        .|.|.....|.::..:..|..||||.| .|.:
  Rat   442 GRQYEV----------EVIVESGNLRNSERCQGRTVPLAVLQLRIKQANETSLGITWRAP-LGEW 495

  Fly   180 SGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGSYQV----------QAYSVY------- 227
            ..:.|.::........:|.|.:..|   .:...|.||.:|:.          |:.|:.       
  Rat   496 EKYTISLMDRELFVIHKSLSKDAKE---YTFTNLMPGRNYKATVTSMSGDLKQSASIQGRTVPAQ 557

  Fly   228 --------QGKESVAYTS-----------------RNFTTKPNTPGKFIVWF------------- 254
                    ||..|..:|:                 .|...|..:......|:             
  Rat   558 VTDLEVSNQGMTSSLFTNWTKALGDVEFYQVLLIHENVVVKNESVSSDSSWYSFRALRSGSLYSV 622

  Fly   255 ----------------------------------RNETTLLVLWQPPFPAGIYTHYRVSITPDD- 284
                                              ||: .|.|.|.|. |..:: ||.|:::.|. 
  Rat   623 VVTTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRND-YLSVSWLPA-PGEVH-HYVVTLSHDSK 684

  Fly   285 AIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFD 349
            .:||::..:...|      .:|..|.|||.||:::.|.|.:..|...:..|  |||::|..::..
  Rat   685 VVQSLITAKFVSE------CSFSSLTPGRLYNVTITTKSGNYESHSFSEER--TVPDKVQGISVS 741

  Fly   350 EAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIF----NVPRAANGDSVYFDYPDILEPGRTY 410
            .: ..|...:|.|  .....:||.|:|.:. :|..|    ::|::.| :.|:..    |.|||.|
  Rat   742 NS-ARSDYLKVSW--VHATGDFDHYEVTIK-NRDSFIQTKSIPKSEN-ECVFAR----LVPGRLY 797

  Fly   411 EVVVKTIADNVNSWPASGEVTLR--PRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQ 473
            .:.|.|   ....:.||.:.|.|  |.||::| ..|:..:..||::|..| .|..|.|.:..  .
  Rat   798 SITVTT---KSGQYEASEQGTGRTIPEPVKNL-TLLNRSTEDLHVTWSRA-NGDVDQYEVQL--L 855

  Fly   474 TNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLI 538
            .|..:|..|.      .:....|||...:|..||.|.|.|..:| |.....:.|...|.|:.  :
  Rat   856 FNDMKVFPPI------YLVNTATEYQFSALTPGRHYKILVLTIS-GDVQQPAFIEGLTVPST--V 911

  Fly   539 QELRSIDQG----LMLSWR---SDVNSRQDRYEVH-YQRNGTREERTMATNETSLTIHYLHPGSG 595
            :.:.....|    |.::|.   .||    |.|.|. ::::...|..|:..:.:..|.|.|..|:.
  Rat   912 KNIHISANGATDRLTVTWSPGGGDV----DSYVVSAFRQDEKVESHTLPKHGSEHTFHRLEAGAT 972

  Fly   596 YEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVH-TNLVVLHWQAPEGSD-------FSEYV 652
            |.:.:.::|..:|::.....|.| |.....:.....: :|.:.:.||...|..       .||..
  Rat   973 YRIAIVSVSGSLRNQIDVLGQTV-PASVHGVVADNAYSSNSLTVSWQKALGMAERYDILLLSENG 1036

  Fly   653 VRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNV-V 716
            |.....:.|      ....:.:.:|:..|::|.:|:.|||.|:.|.. :|......|..|:|: :
  Rat  1037 VLLSNTSEP------ATVKQHKFEDLTPGKKYKMQILTVSGGLFSKE-VETEGRTVPAAVTNLRI 1094

  Fly   717 PLVDSRNLTLEWPRPDGHVDFYTLKWWPTDE--EDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQ 779
            ....||:|:..|...:|.:.:|.:..:..|:  ::|.:...:.|         ....::|..||.
  Rat  1095 TENSSRHLSFSWTASEGELSWYNIFLYNPDKTLQERAQVDPLVQ---------SFSFQNLLQGRM 1150

  Fly   780 YRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT----LSYTPTPADSTRFD 840
            |:. |..:.:|..|..:.:..||:|        |...|.:|.:..:|    .|::|...|   ||
  Rat  1151 YKM-VIVTHSGELSNESFIFGRTVP--------AAVNHLKGSNRNMTDSLWFSWSPASGD---FD 1203

  Fly   841 IYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISD 905
            .|...:.:|....||........:..|.||.||:.|.:.|.|.||.::: .|....|..|.|.|.
  Rat  1204 FYELILYNPNGTKKENWREKDVTEWRFQGLIPGRKYTLYVVTHSGDLSN-KVTGEGRTAPSPPSL 1267

  Fly   906 LKAIQVAAREITLHWTAPAG--EYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFT 968
            |....||...:.:.|..|..  :|.|||||:|..|........:..|:....:.||||..:|.|:
  Rat  1268 LSFADVANTSLAITWKGPPDWTDYNDFELQWLPGDALTVFNPYSSKKSEGRIVNGLRPGRSYQFS 1332

  Fly   969 VVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAE 1033
            |...||....|            .|.|||.|.:|   .|.|:............:...| :.|  
  Rat  1333 VKTVSGDSWKT------------YSKPISGSVRT---KPDKIQNLHCRPQNSTAIACSW-IPP-- 1379

  Fly  1034 QHGPIDYFRITCQNADDAADVSSYEFPVNATQGK----IDGLVPGNHYIFRIQAKSALGYGAERE 1094
             ....|.:.|.|:.    .|....||.....:.|    |..|||...|:..|:.:|| |..:|..
  Rat  1380 -DSDFDGYSIECRK----MDTQEIEFSRKLEKEKSLLNIMMLVPHRRYLVSIKVQSA-GVTSEVV 1438

  Fly  1095 HIQTMPIL---APPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASG 1156
            ...|:.::   .||.|...|...:|..:.|:|..:....:||:.:|.|:.:.:::.|     |..
  Rat  1439 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVRE-----ADS 1498

  Fly  1157 LE---------MPSWQD------VQAY-TVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTAN 1205
            ::         :||:.:      ::.| |.:...:..|..:|..:|. |....|..|..::| ..
  Rat  1499 MDELRPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAESPDPDRSSK-SFNIKLGGEMDSLG-GK 1561

  Fly  1206 CDKHQAGYCNGPLRAGTTYRIKIRAFT---DE--DKFT-----DTVYSSPITTERSDTVIVAATV 1260
            ||..|..:|:|||:..|.|||.|||||   ||  .:||     ||.:|.|||||......|...|
  Rat  1562 CDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPITTESEPLFGVIEGV 1626

  Fly  1261 SA-VLLVAMVLVVV---YCQHRCQLIRRAS--KLARMQDELAAL-----PEGYITPNRPVHVKDF 1314
            || :.|:.|::.:|   .|:.:....|..|  :|:..:|...::     .:|....:.|:.:..|
  Rat  1627 SAGLFLIGMLVALVAFFICRQKASHSRERSSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQF 1691

  Fly  1315 SEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDD 1379
            ..|:..:.|||::..|:|:|:||.|||.|:|..|.||.||.|||:.||||||.||.||..||||.
  Rat  1692 EGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDP 1756

  Fly  1380 GSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV 1444
            .||||||:|:||:|..||:|.|||||..|:::||:|.||.|...|||:|:|.||||.|||.|||.
  Rat  1757 CSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPA 1821

  Fly  1445 DRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCES------RIMRHFHFTTWPDFGVPEPPQSL 1503
            |:..::|||:.:|::.::...:|:|.||.:   |..      |::||||:|.|||.||||..|||
  Rat  1822 DQDPLYYGDLILQMVSESVLPEWTIREFKI---CSEEQLDAHRLLRHFHYTVWPDHGVPETTQSL 1883

  Fly  1504 VRFVRAFRDVIGTD--MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVF 1566
            ::|||..||.|...  ..|.:|||||||||:|||:|||||||.:...|.|||:|.|..:|..||.
  Rat  1884 IQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVH 1948

  Fly  1567 MVQTEQQYVCIHQCLLAVLEGKE 1589
            |||||.|||.:|||:..||..::
  Rat  1949 MVQTECQYVYLHQCVRDVLRARK 1971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 24/132 (18%)
fn3 247..328 CDD:278470 24/128 (19%)
fn3 343..417 CDD:278470 19/77 (25%)
fn3 443..525 CDD:278470 22/81 (27%)
FN3 548..611 CDD:238020 16/66 (24%)
FN3 620..706 CDD:238020 19/93 (20%)
fn3 708..796 CDD:278470 19/90 (21%)
fn3 824..886 CDD:278470 19/65 (29%)
fn3 902..978 CDD:278470 25/77 (32%)
fn3 1013..1092 CDD:278470 18/82 (22%)
UP_III_II 1106..>1248 CDD:297589 47/167 (28%)
PTPc 1329..1582 CDD:214550 144/260 (55%)
PTPc 1355..1582 CDD:238006 129/234 (55%)
PtprbNP_001359063.1 fn3 113..195 CDD:365830
FN3 204..273 CDD:214495
fn3 292..365 CDD:365830
fn3 394..455 CDD:365830 11/70 (16%)
fn3 470..542 CDD:365830 16/75 (21%)
fn3 645..723 CDD:365830 23/86 (27%)
fn3 733..809 CDD:365830 20/87 (23%)
fn3 822..895 CDD:365830 24/83 (29%)
fn3 909..982 CDD:365830 15/78 (19%)
fn3 1009..1077 CDD:365830 17/73 (23%)
fn3 1088..1161 CDD:365830 16/82 (20%)
fn3 1176..1249 CDD:365830 21/75 (28%)
fn3 1263..1341 CDD:365830 25/77 (32%)
fn3 1357..1436 CDD:365830 19/87 (22%)
PTP_tm 1460..1648 CDD:376280 56/194 (29%)
R-PTPc-B 1734..1961 CDD:350465 125/229 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 285 1.000 Domainoid score I1546
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 564 1.000 Inparanoid score I1035
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 1 1.000 - - FOG0001181
OrthoInspector 1 1.000 - - otm44977
orthoMCL 1 0.900 - - OOG6_106915
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4185
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.870

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