Protein Alignment Ptp4E and ephb4b

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_571492.1
• Gene: ephb4b / 30691
• ZFINID: ZDB-GENE-990415-65
• Length: 976
• Species: Danio rerio
• Alignment Length: 780
• Identity: 143/780 - (18%)
• Similarity: 247/780 - (31%)
• Gaps: 268/780 - (34%)

  Fly   910 QVAAREITLHWTAPAGEYTDFELQY-------------LSADEEAPQLLQNVTKNTEITLQGLRP 961
            |:....:||.|:.|.......:|.|             ..||....:..|.......:.::||.|
Zfish   336 QINDTVVTLEWSEPLDRGGRSDLSYSVECMHCRGSLCVQCADSITYRPGQMGVSGRRVIIRGLLP 400

  Fly   962 YHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTA-----PPGKVDYFQPSDVQPG 1021
            :..|||||:.::|           ||.:..:| |.|:|....|:     |...:...:.|:   .
Zfish   401 HTTYTFTVLAQNG-----------VSAVSHTS-PASSSVNITTSRDVAVPVSGIRRIKASE---S 450

  Fly  1022 EVTFEWSLEPAEQHGPIDY-FRITCQNADDAAD-VSSYEFPVNATQGKIDGLVPGNHYIFRIQAK 1084
            .|:..|::.|..||...|| .|.:.:..||... |||     .::...::.|...:.|..:::|:
Zfish   451 SVSISWTVPPQTQHSIQDYQLRYSLKGQDDGWQYVSS-----RSSSVVLNDLSRASQYQVQVRAR 510

  Fly  1085 SALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIA-- 1147
            :|.|||    |..: .:....:|:...:|..:..|...:.|..          ::....:|:|
Zfish   511 TAAGYG----HFSS-AVSISTLPDDEESPSRLMLTGVLVAIGL----------LILIAVVIVAVF 560

  Fly  1148 --------EDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAE------H 1198
                    .|...:.|| :....|.::.|        |:|:.....:...|:.:.|.:      .
Zfish   561 CFRRSTRRRDPDPDKSG-QFLMGQGIKVY--------IDPFTYEDPNEAVREFAKEIDVSFVKIE 616

  Fly  1199 FTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAV 1263
            ..||.....:    .|.|.|:........:...|.:..:||
Zfish   617 EVIGAGEFGE----VCRGRLKVPGKKENYVAIKTLKGGYTD------------------------ 653

  Fly  1264 LLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFR 1328
                        :.|...:..||.:.:.|.......||.||.:.||.:  .:|:....:.||..|
Zfish   654 ------------KQRRDFLSEASIMGQFQHPNIIHLEGVITASCPVMI--LTEYMENGALDSFLR 704

  Fly  1329 FSE-EF-------------------EELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQ 1373
            .:: :|                   .|:..|.||.|.  .|:..|  .|....:..:..|||..:
Zfish   705 LNDGQFTPIQLVGMLRGIASGMKYLSEMSFVHRDLAA--RNILVN--SNLVCKVSDFGLSRFLTE 765

  Fly  1374 PVDDDDGSDYINANYMPGHNSP-----REFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEK 1433
            ...|...:..:.........:|     |:|        ::..:.|       |..|||
Zfish   766 NSSDPTYTSSLGGKIPIRWTAPEAIAFRKF--------TSASDVW-------SYGIVM------- 808

  Fly  1434 GREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPE 1498
                    |.|    |.:|:...          |.:|...|....|.            |:.:|.
Zfish   809 --------WEV----MSFGERPY----------WDMSNQDVINAIEQ------------DYRLPP 839

  Fly  1499 PPQ----------------------------SLVRFVR--AFRDVIG----------TDMR--PI 1521
            ||:                            :|.|.:|  |...:.|          .|.|  |.
Zfish   840 PPECPASLHQLMLDCWQKERSSRPRFCAIVSALDRLIRNPASLKITGRIPDGPSHPLLDQRAPPP 904

  Fly  1522 IVHCSA---------------GVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVF-MVQT 1570
            :.|||:               ...::| |.|:..| .||...|.:.| |:..|..::::. .|||
Zfish   905 LSHCSSVADWLRAIKMERYEDAFMQAG-FTAIQHI-THISTEDLLRI-GVTLAGHQKKILSSVQT 966

  Fly  1571  1570
            Zfish   967  966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996	19/80 (24%)
		fn3	1013..1092	CDD:394996	21/80 (26%)
		PTP_tm	1127..1247	CDD:465889	19/135 (14%)
		R3-PTPc	1358..1579	CDD:350396	48/276 (17%)
ephb4b	NP_571492.1	EphR_LBD	25..198	CDD:470656
		FN3	327..431	CDD:238020	25/106 (24%)
		FN3	438..526	CDD:238020	23/100 (23%)
		EphA2_TM	540..610	CDD:464211	13/88 (15%)
		PTKc_EphR_B	608..876	CDD:173638	57/369 (15%)
		SAM_superfamily	906..969	CDD:472832	16/64 (25%)