Protein Alignment Ptp4E and epha4l

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_687698.2
• Gene: epha4l / 30687
• ZFINID: ZDB-GENE-990415-61
• Length: 988
• Species: Danio rerio
• Alignment Length: 969
• Identity: 188/969 - (19%)
• Similarity: 309/969 - (31%)
• Gaps: 300/969 - (30%)

  Fly   502 SLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSID----QGLMLSWRSDVNSRQDR 562
            :|:||..|  |:.:|..|:.:..|      .|.:|...|:..:|    || .|:|.:...
Zfish     2 ALMAGIIY--ALTSLFLGICAGLS------APRSPPANEVTLLDSRSVQG-ELAWVASPT----- 52

  Fly   563 YEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLT 627
             |..::.....:|:.:.. .|....:.:.|.....::.|.|..|  :....|.:..|.....|..
Zfish    53 -EGGWEEVSIMDEKNIPI-RTYQVCNVMEPSQNNWLRTHWIQRG--AAQRIYIEIKFTLRDCNSL 113

  Fly   628 LQTVHT-----NLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQ 687
            ...:.|     ||..|.    ..||...|     ...|.:.:|..:..:|: ...:..|:| :::
Zfish   114 PGVIGTCKETFNLYYLE----SDSDNERY-----AHESRFSKIDTVAADES-FTQVDIGDR-IMK 167

  Fly   688 VNTV--SFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFY--------TLKW 742
            :||.  ..||.|    .....:..|.|...:.||..            || ||        .|..
Zfish   168 LNTEVRDVGVLS----RAGFYLAFQDVGACIALVSV------------HV-FYKKCPLAVRNLAQ 215

  Fly   743 WP-----TDEEDRVEFKN--VTQLEDLSSPSV--------RIPIED--LSPGRQYRFE-VQASSN 789
            :|     .|....||.:.  |...|:...|.:        .:||.:  .:||.:.|.| .|....
Zfish   216 FPDTVTGADTSSLVEVRGSCVDHSEEQEVPKMYCGADGEWLVPIGNCLCNPGYEERIEQCQVCKV 280

  Fly   790 G-IRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT-----LSYTPTPADSTRFDIYRFSMGD 848
            | .||.::.:..|..||           |.....|..|     ..|..:..|.......|
Zfish   281 GYYRSLSSDVGCRKCPL-----------HSYSVKEGATSCDCDKGYYRSETDPAAMPCTR----- 329

  Fly   849 PTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAA 913
            |.......::|..|..:......|         ..|||...|....:.:         :.::...
Zfish   330 PPSAPHNLISNVNETSVLLDWSPP---------LSSGGRQDLTYNVVCK---------QCVRDTQ 376

  Fly   914 REITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQG 978
            |      .:|.|:    :::|      :||.|.  .::|.:::..|:.:.||||.:...:|
Zfish   377 R------CSPCGD----DVRY------SPQRLS--LRSTRVSVHQLQAHTNYTFQIWAING---- 419

  Fly   979 TDFADVSVSTLMRSSAPISASYQTLT---APPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDY 1040
                   ||  ..:.:|..|...|||   |.|..|...|..|:....:...|. :|.:.:|.|..
Zfish   420 -------VS--KHNPSPEQAVSVTLTTNQAAPSMVMSVQSKDITRHTLALFWD-QPEKPNGVILE 474

  Fly  1041 FRITCQNADDAADVSSYEFPVNATQGKID--GLVPGNHYIFRIQAKSALGYG--AEREHIQTMPI 1101
            :.:.....|.  :..||.. |..|....|  .|.|...|:|.::|::|.|||  :......|..:
Zfish   475 YEVKYYEKDQ--NERSYRI-VKTTSRNADIKDLTPLTSYVFHVRARTAAGYGDFSAPFEFSTNTV 536

  Fly  1102 LAP---PVPEPSVTPLEV---------------------SRTSSTIEISFRQGYFSNAHGMVRSY 1142
            .||   .|...:|..|.|                     |:.|.|     :||...|....||.|
Zfish   537 AAPVVGGVMSSAVLLLLVAGCVVVLLLILIITFIFTKRRSKYSKT-----KQGEDKNVQQGVRIY 596

  Fly  1143 TIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCD 1207
                                  |..:|...|.|||..:...:.:     |.::.|. .||.....
Zfish   597 ----------------------VDPFTYEDPNQAIREFAKEINT-----SCIKIEK-VIGIGEFG 633

  Fly  1208 KHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVV 1272
            :    .|:|.|:......|.:...|.:..||:
Zfish   634 E----VCSGRLKLPGKREICVAIKTLKAGFTE--------------------------------- 661

  Fly  1273 VYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSAD-----SDFRFS-- 1330
               |.|...:..||.:.:.........||.:|..:||.:  .:|:....|.|     :|.||:
Zfish   662 ---QQRLDFLSEASVIGQFDHPNIIHLEGVVTKCKPVMI--ITEYMENGSLDMFLRKNDGRFTVI 721

  Fly  1331 -------------EEFEELKHVGRDQACS----FANLPC------------NRPKNRFT 1360
                         :...::.:|.||.|..    .:||.|            :.|:..:|
Zfish   722 QLVGILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDEPEGAYT 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	54/270 (20%)
		fn3	708..796	CDD:394996	26/114 (23%)
		fn3	902..978	CDD:394996	14/75 (19%)
		fn3	1013..1092	CDD:394996	21/82 (26%)
		PTP_tm	1127..1247	CDD:465889	23/119 (19%)
		R3-PTPc	1358..1579	CDD:350396	1/3 (33%)
epha4l	XP_687698.2	EphR_LBD	32..205	CDD:470656	41/210 (20%)
		FN3	331..437	CDD:238020	27/154 (18%)
		FN3	442..533	CDD:238020	23/94 (24%)
		EphA2_TM	536..617	CDD:464211	21/107 (20%)
		PTKc_EphR_A	616..882	CDD:270651	35/213 (16%)
		SAM_EPH-A4	913..983	CDD:188944