Protein Alignment Ptp4E and Ptprn2

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_038967789.1
• Gene: Ptprn2 / 29714
• RGDID: 61904
• Length: 1026
• Species: Rattus norvegicus
• Alignment Length: 1115
• Identity: 258/1115 - (23%)
• Similarity: 392/1115 - (35%)
• Gaps: 329/1115 - (29%)

  Fly   698 PHPLELNVTMPPQPVSNVVPL-VDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKN-----V 756
            |.||.|.:.:|| |:...:|. ..:|...|                 |.....|:|.:|     |
  Rat     4 PLPLLLLLLLPP-PLPRALPAPASARGRQL-----------------PGRLGKRMELENPILSDV 50

  Fly   757 TQ---------LEDLSSPSVRIPIEDLSPGR--------QYRFEVQASSNGI------------R 792
            ||         .||....|:...:.|...||        .||:||   |.|.            |
  Rat    51 TQNQKDTYGCLFEDGLCGSLETCVNDGVFGRCQKVPALDTYRYEV---SPGALLHLRIILQKLSR 112

  Fly   793 SGTTHLSTRTMPLIQ---SDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDK 854
            :|.|.....|..:|.   |::..|...||:......:|...   ||:.::    ||     ::.:
  Rat   113 TGFTWQDDYTQRVIAQELSNLPKAYLWHEEASSPARSLQQN---ADNEKW----FS-----LESE 165

  Fly   855 EKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQ--------- 910
            ..||....|.|.:..|                ::..|..   ..||....:.:.::
  Rat   166 VALAKTLRRYLPYLEL----------------LSQAPTA---NAHPRIDHETRPVKGEDSSPENI 211

  Fly   911 ---VAAREITLHWTAPAGEYTDFELQYLS---ADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTV 969
               ||......:..|...:|.|..|:.||   .||.:|::..::.|...|...|       .:|.
  Rat   212 LTYVAHTSALTYPPATRVKYPDNLLRPLSRLQPDELSPKVDSDIDKQKLIAALG-------AYTA 269

  Fly   970 VVRSGSIQGTDFADVSVSTLMRSSAPISAS--YQTLTAPPGKVDYFQPSDVQPGEVTFEWS-LEP 1031
            ....|  :........|.:.||:..|.:|.  .|....|||.    ....:..|:.|...| |:.
  Rat   270 QRPPG--ENDPEPRYLVHSPMRAPRPFAAPALSQRWPLPPGD----SKDSLSMGDDTLLRSLLKD 328

  Fly  1032 AEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHI 1096
            .:|...:|  |:.....::.||..:.....:..:|..:....|.....|.||      .|..|.:
  Rat   329 LQQQAEVD--RLGSLKLEEQADSIAGAIQSDPVEGSQESHGRGAEGQLREQA------DAPEEML 385

  Fly  1097 QTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGM----------------------- 1138
            |...:  |.|.:|:... ||||      :||:.|.....||.
  Rat   386 QDHRL--PEVDDPAAYK-EVSR------LSFKLGDLLKDHGSPLLPEAPLLEKSSRAEMKKSEQP 441

  Fly  1139 ---------------VRSYTIIIAEDVGKNASGLEMPSWQ-----DVQAYTVWLPYQAIEPYNPF 1183
                           |:|.|  .::|:.:.....|...|:     ..:|..||...|.::
  Rat   442 EEVLSSEEETAGVEHVKSRT--YSKDLLERKPNSEPQPWRLEDQFQNRAPEVWEDEQNLK----- 499

  Fly  1184 LTSNGSRKSSLEAEHFTIGTANCDKHQAGYC---NGPL--------------------------- 1218
            |.:.|.....|:.|     ....::.|.||.   |.||
  Rat   500 LAAQGPPSGGLQLE-----VQPSEEEQQGYILTGNNPLSPEKGKQLMDEVAHLLRVPSSFFADVK 559

  Fly  1219 --------------RAGTTYRIKIRAFTDEDKFTD----TVYSS-----------PITTERSDT- 1253
                          :..||..:...|..::|:...    |:..|           |...|:.|:
  Rat   560 VLGPAVIFKVSANIQNMTTADVTKAAVDNKDELEKATGLTILQSGIRPKGKLKLLPHPEEQEDST 624

  Fly  1254 ---VIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARM-QDELAALPEGY---ITPNRPVHV 1311
               |:...:::.:|.|.:...:.||.......:...||:.: .|..|...|.|   ......|..
  Rat   625 KFIVLTFLSIACILAVLLASSLAYCLRHNSHYKLKEKLSGLGADPSADATEAYQELCRQRMAVRP 689

  Fly  1312 KDFSE--H-YRIMSADSDF---------------RFSEE------------------FEELKHVG 1340
            :|.||  | .||.|..|..               .:|||                  .:.||:..
  Rat   690 QDHSEGPHTSRINSVSSQLSDGPMPSPSARSSTSSWSEEPAQSNMDISTGHMILAYMEDHLKNKN 754

  Fly  1341 R-----DQACSFANLPC---------NRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPG 1391
            |     :..|::...|.         |.||||...:|.|||||..|:..:....||||||:.:..
  Rat   755 RLEKEWEALCAYQAEPDSSLVAQREENAPKNRSLAVLTYDHSRILLKSENSHSNSDYINASPIMD 819

  Fly  1392 HNSPRE--FIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDI 1454
            |: ||.  :|.|||||.:|..:||:|.|||....|||||...|.|..:|..||| |..:..|...
  Rat   820 HD-PRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWP-DEGSNVYHVY 882

  Fly  1455 KVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRD 1512
            :|.|:.:   |.| ..:|:|.       :..|:|.:..|||.:|.|.|||...:||:.|.|....
  Rat   883 EVNLVSE---HIW-CQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNK 943

  Fly  1513 VIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK-SDYVDIFGIVFAMRKERVFMVQTEQQYVC 1576
            .......|||||||.|.|||||::.:|.:|..:.| :..:||...:..:|.:|..||||::|:
  Rat   944 CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQF-- 1006

  Fly  1577 IHQCLLAVLE 1586
             ...|.||.|
  Rat  1007 -EFALTAVAE 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	11/51 (22%)
		fn3	708..796	CDD:394996	27/122 (22%)
		fn3	902..978	CDD:394996	16/90 (18%)
		fn3	1013..1092	CDD:394996	14/79 (18%)
		PTP_tm	1127..1247	CDD:465889	31/221 (14%)
		R3-PTPc	1358..1579	CDD:350396	88/230 (38%)
Ptprn2	XP_038967789.1	RESP18	<102..>148	CDD:464394	9/45 (20%)
		Receptor_IA-2	520..608	CDD:463293	12/87 (14%)
		R-PTP-N2	738..1020	CDD:350458	101/287 (35%)