DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and pyp3

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_594934.1	Gene:	pyp3 / 2541443	PomBaseID:	SPAC11E3.09	Length:	303	Species:	Schizosaccharomyces pombe

Alignment Length:	253	Identity:	94/253 - (37%)
Similarity:	147/253 - (58%)	Gaps:	20/253 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1356 KNRFTNILPYDHSRFKLQPVDDDDGSDYINANY--MPGHNSPREFIVTQGPLHSTREEFWRMCWE 1418
            :||::||:||:::|.:|.|: ..:..|||||:.  :|   |.:.||.||||..::.:.||:|.|:
pombe    52 RNRYSNIVPYENTRVRLDPM-WKEACDYINASIVKIP---SGKTFIATQGPTSNSIDVFWKMVWQ 112

  Fly  1419 S--NSRAIVMLTRCFEKGREKCDQYWPVDRV-AMFYGDIKVQLI---IDTHYHDWSISEFMVSRN 1477
            |  .|..|||||:..|:.|.|||.||||:.. .:..||:.|.|:   ..|..::..:.||.::::
pombe   113 SVPKSGIIVMLTKLRERHRLKCDIYWPVELFETLNIGDLSVILVKVYTLTSLNEVQVREFELNKD 177

  Fly  1478 CESRIMRHFHFTTWPDFGVPEPPQ--SLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDR 1540
            ...:.:.||::..|||||.|....  ||.|::::.......:..|||||||||.||:|||:||..
pombe   178 GVKKKILHFYYNGWPDFGAPHTFSLLSLTRYIKSLSYSPDFETAPIIVHCSAGCGRTGTFMALFE 242

  Fly  1541 ILQH------IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLL 1592
            ||..      ..|.:..:|..||.::|.:|:..||:..|.|.::.....:|:|||.||
pombe   243 ILSQTDDSTSTSKFEVDNIANIVSSLRSQRMQSVQSVDQLVFLYTVSQELLQGKEFLL 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020
		fn3	708..796	CDD:278470
		fn3	824..886	CDD:278470
		fn3	902..978	CDD:278470
		fn3	1013..1092	CDD:278470
		UP_III_II	1106..>1248	CDD:297589
		PTPc	1329..1582	CDD:214550	88/241 (37%)
		PTPc	1355..1582	CDD:238006	88/241 (37%)
pyp3	NP_594934.1	COG5599	1..303	CDD:227886	94/253 (37%)
		AbiGii_2	<18..69	CDD:293478	7/16 (44%)
		PTPc	52..291	CDD:238006	88/242 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1041
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47137
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840