Protein Alignment Ptp4E and Ptprc

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_612516.2
• Gene: Ptprc / 24699
• RGDID: 3451
• Length: 1273
• Species: Rattus norvegicus
• Alignment Length: 1245
• Identity: 270/1245 - (21%)
• Similarity: 452/1245 - (36%)
• Gaps: 330/1245 - (26%)

  Fly   575 ERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLH 639
            ||...::||:    || ||....:..|     :..:|.|...:......|.|:.|...|.|..
  Rat    59 ERGNGSSETT----YL-PGFSSTLMPH-----LTPQPDSQTPSARGADTQTLSSQADLTTLTA-- 111

  Fly   640 WQAPEG----------SDFSE-------YVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQ 687
              ||.|          |...|       .:.|..|..||      .|.:.....|:..|......
  Rat   112 --APSGETDPPGVPEESTVPETFPGGTPILARNSTAPSP------THTSNVSTTDISSGANLTTP 168

  Fly   688 V-NTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSR--NLTLEWPRPDGHVDF-YTLKWWPTDEE 748
            . :|:.|...:....|:   ..||    ..|..|.:  |:|:.:...|...:| ..|:   .|::
  Rat   169 APSTLGFASNTTTSTEI---ATPQ----TKPSCDEKFGNVTVRYIYDDSSKNFNANLE---GDKK 223

  Fly   749 DRVEF----KNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLS-TRTMPLIQS 808
            .:.|:    |.:..|.:.|..:|.:.....:|.:....:|.       .||.:.: |...|.|::
  Rat   224 PKCEYTDCEKELKNLPECSQKNVTLSNGSCTPDKIINLDVP-------PGTHNFNLTNCTPDIEA 281

  Fly   809 DVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPG 873
            :..|.       .:..|...:|        .||.:.|.......:.:..|.|....|....||..
  Rat   282 NTSIC-------LEWKIKNKFT--------CDIQKISYNFRCTPEMKTFALDKHGTLWLHNLTVR 331

  Fly   874 KLYNVTVWTVSGGVASLPVQRLYRLH---PLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYL 935
            ..|......:...|..|...|..:..   |..:..::..........:.|..||.::..:.|.|.
  Rat   332 TNYTCAAEVLYNNVILLKQDRRVQTDFGTPEMLPHVQCKNSTNSTTLVSWAEPASKHHGYILCYK 396

  Fly   936 SADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASY 1000
            ....|..:.|.|...:.|:  :.||||..||.::           ||.| :..:.|:......::
  Rat   397 KTPSEKCENLANDVNSFEV--KNLRPYTEYTVSL-----------FAYV-IGRVQRNGPAKDCNF 447

  Fly  1001 QTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQ 1065
            :|..|.||||:..:.|......:                  .:||.        |.||
  Rat   448 RTKAARPGKVNGMKTSRASDNSI------------------NVTCN--------SPYE------- 479

  Fly  1066 GKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQG 1130
              |:|  |...||..:::..:|        ::|.                   ..||.:......
  Rat   480 --ING--PEARYILEVKSGGSL--------VKTF-------------------NQSTCKFVVDNL 513

  Fly  1131 YFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLE 1195
            |:|.      .|..::
  Rat   514 YYST------DYEFLV------------------------------------------------- 523

  Fly  1196 AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATV 1260
              :|         :...|...|       .||                 |.:|..:...::...|
  Rat   524 --YF---------YNGEYLGDP-------EIK-----------------PQSTSYNSKALIIFLV 553

  Fly  1261 SAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADS 1325
            ..:::.::.|:||..:......:|:|.|...|:.:....|..:....|:|.....|.|:...||.
  Rat   554 FLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDEEKQLINVDPIHSDLLLETYKRKIADE 618

  Fly  1326 DFRFSEEFEELKHVGRDQACSFANLPC-------NRPKNRFTNILPYDHSRFKLQPVDDDDGSDY 1383
            ...|..||:.:..|       |:..|.       |:.|||:.:|||||::|.:|..::.|.||.|
  Rat   619 GRLFLAEFQSIPRV-------FSKFPIKDARKSQNQNKNRYVDILPYDYNRVELSEINGDAGSTY 676

  Fly  1384 INANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-VDRV 1447
            |||:|:.|...||::|..|||...|.::||:|.||..:..|||:|||.|..|.||.:||| ::..
  Rat   677 INASYIDGFKEPRKYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEG 741

  Fly  1448 AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE---SRIMRHFHFTTWPDFGVPEPPQSLV---RF 1506
            ...:.|:.|.:.......|:.|.:..::...|   .|.:.|..||:|||.||||.|..|:   |.
  Rat   742 TRTFRDVVVTINDHKRCPDYIIQKLSIAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRR 806

  Fly  1507 VRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTE 1571
            |.||.:...   .||:|||||||||:||:|.:|.:|:.:.....||::|.|..:|::|..|||.|
  Rat   807 VNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQRCLMVQVE 868

  Fly  1572 QQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRAS---LAMAEK 1633
            .||:.|||.|:      |:......|::.::.:...:...:|.|.:...  |:.|.   |.....
  Rat   869 AQYILIHQALV------EYNQFGETEVNLSELHSCLQNLKKRDPPSDPS--PLEAEYQRLPSYRS 925

  Fly  1634 LDADLMTNKDEDEDQEQQQQ------QQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETT 1692
            .....:.|::|::.:.:...      .::.|..|::....::.|.||..|:|.|       :|.|
  Rat   926 WRTQHIGNQEENKKKNRSSNVVPYDFNRVPLKHELEMSKESEAESDESSDEDSD-------SEET 983

  Fly  1693 ATLSSASCSSSTHDVHVVLQEAIEKPKQE--------------------------QERICA---- 1727
            :...:||...|.....:::  |.:.|.:|                          .:.:||
  Rat   984 SKYINASFVMSYWKPEMMI--AAQGPLKETIGDFWQMIFQRKVKVIVMLTELMSGDQEVCAQYWG 1046

  Fly  1728 -GTQSHADTE 1736
             |.|::.|.|
  Rat  1047 EGKQTYGDME 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	41/194 (21%)
		fn3	708..796	CDD:394996	18/94 (19%)
		fn3	902..978	CDD:394996	15/75 (20%)
		fn3	1013..1092	CDD:394996	12/78 (15%)
		PTP_tm	1127..1247	CDD:465889	9/119 (8%)
		R3-PTPc	1358..1579	CDD:350396	93/227 (41%)
Ptprc	NP_612516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..192		33/159 (21%)
		PHA03255	82..>191	CDD:165513	24/125 (19%)
		CD45	203..259	CDD:432641	10/58 (17%)
		FN3	366..431	CDD:238020	16/77 (21%)
		FN3	454..534	CDD:238020	24/209 (11%)
		Wzy_O6_O28	521..>580	CDD:468211	12/142 (8%)
		R-PTPc-C-1	676..876	CDD:350405	82/202 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	960..984		7/30 (23%)
		R-PTP-C-2	986..1191	CDD:350406	12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1219..1273