DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprz1

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	1945	Identity:	419/1945 - (21%)
Similarity:	666/1945 - (34%)	Gaps:	610/1945 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 KFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYS 180
            ||||.:          :::.|.:|:    ::.......|.|:.....:..|..:||..|
Mouse   291 KFSRQV----------FSSYTGKEE----IHEVVCSSEPENVQADPENYTSLLVTWERP------ 335

  Fly   181 GFRIRVLGLTDLPFER----------------SYSLEGNETLQLSAKELTPGGSYQVQ------- 222
                ||  :.|...|:                .:..:|.:.|......|.|..||.:|
Mouse   336 ----RV--VYDAMIEKFAVLYQPLAGNDQAKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAVCSN 394

  Fly   223 -AYSVYQ---------------------GKESV----AYTSRNFTTKPNTPGKFIVWFRNETTLL 261
             .|..|.                     |.|.:    .|...|.......||      |:..|..
Mouse   395 GLYGKYSDQLIVDMPTEDAELDLFPELIGTEEIIKEEEYGKDNEEDTGLNPG------RDSVTNQ 453

  Fly   262 VLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDE 326
            :..:.| .....|||....|..:..::      ...|...::.:.|..||....|.:.|.|:|.|
Mouse   454 IRKKEP-QVSTTTHYNHMGTKYNEAKT------NRSPTRGSEFSGKSDVPNTSPNSTSQHVAEFE 511

  Fly   327 TS---SVPTTARYLTVPERV------LN------VTFDEAYTTSSSFRVRWEPPRTYSEF----- 371
            |.   |:|:.......|..|      ||      ..|.:...:.::..:...|...|.|.
Mouse   512 TERGISLPSQTGTNLPPHNVEGTSASLNSGSKTLFIFPQMNLSGTAESLNTVPITEYKEVSADVS 576

  Fly   372 ----------------DAYQVMLSTSRRIFNVPRAANGDSVYFDYP-----DILEPGRT------ 409
                            |:.....|||...|:....::|.....|.|     |:|:||.|
Mouse   577 EEENFLTDFKLDTGADDSSGSSPSTSTVPFSSDNLSHGYITSSDMPEAITYDVLKPGSTRNAPED 641

  Fly   410 -----YEVVVKTIADNVNSW-PASGEVTLRPRPVRSLGGFLDDRSNALHI--------SWEPAET 460
                 .|..:|..:...:.| |.|.::|.:.........||...|..:.|        |:.|..|
Mouse   642 SAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGRESFLQVNSTDIQIDESRETTESFSPDAT 706

  Fly   461 GRQD------------SYRISYHEQTNASEVPAPFPV-------AAESQITTNL--------TEY 498
            ..||            ::.....|.|..:..|:..|:       ...||.|..:        ..|
Mouse   707 VSQDPSVTDMGMPHYSTFAYLPTEVTPQAFTPSSRPLDLAPTINILHSQTTQPVYNGETPLQPSY 771

  Fly   499 TLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLI-----QELRSIDQGLMLSWRSDVNS 558
            :.:........|:..|.|:...|:::||...:..|.:|.:     ..|.|.|...:|.: |..:.
Mouse   772 SSEVFPLATPLLLDNQTLNTTPAASSSDSALHATPVSPSVGVSFESILSSYDDAPLLPF-SSASF 835

  Fly   559 RQDRYEVHYQRNGTREERTMATNETSLTIH----------YLHPG-------SGYEVKVHAISH- 605
            ..:.:...:..:.|..:.|.|.....|::|          .|.|.       :.::....|.|.
Mouse   836 SSEMFRHLHTVSQTLPQVTSAAERDELSLHASLLVARGDLLLEPSLVQYSDVASHQATTRAASDT 900

  Fly   606 -GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLH 669
             |..||     .|||.|......:::..:: ||:|              .|.:...|...:.|.|
Mouse   901 LGFGSE-----SAVFYKTSMVSQIESPRSD-VVMH--------------AYSSGPEPSYTVEGSH 945

  Fly   670 ENEARIKDMHYGERYLVQVNTVSFGVESP---------------HPLEL------------NVTM 707
                             .|.|||:....|               :|..:            ::..
Mouse   946 -----------------HVPTVSYSSAMPLHGSVDVSDQGSLLINPSHISMPESSFITPTASLLQ 993

  Fly   708 PPQPVSN-------------VVPLVDSRNLTLEWPRPDGHVDF-YTLKWW-----PTDEEDRVEF 753
            ||..:|.             ::|..|... ||....|....:| ||...:     |..:.:.: :
Mouse   994 PPPALSGDGEWSGASSDSELLLPDADGLR-TLNISSPVSVAEFTYTTSVFADGIKPLSKSEMM-Y 1056

  Fly   754 KNVTQLE-----DLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIA 813
            .|.|:|:     |::.||....:..:|.      .|...|..::..:..:|:......:|.|:..
Mouse  1057 GNETELKMSSFSDMAYPSKSTVVPKMSD------VVHKWSESLKETSVSISSMKSVFPESLVYPT 1115

  Fly   814 NAGHEQGQDET--ITLSYTPTPADSTRFDIYRFSMGDPTIK-----DKEKLANDTERK------- 864
            ..|.|||....  |.....||...|.       :.||..:|     :.|...:||..:
Mouse  1116 TKGFEQGVSHVPEIIFPVQPTHTASQ-------ASGDTWLKPGLSANSEAAFSDTASREVVHPST 1173

  Fly   865 --LSFSGLTPGKLYN---------------VTVWTVSGGVASLPVQRLYRLHPLP--------IS 904
              |.:...||   :|               ..:.|....|.|.|:     |...|        :|
Mouse  1174 QPLLYEAATP---FNTEALLQPSFQASDVDTLLKTALPSVPSDPI-----LAGTPQVEQSSSSVS 1230

  Fly   905 DLKAIQVAAREITLHWT-------APAGEYT-------------DFELQYLSADEEAPQLLQNVT 949
            ...|.:..:.|..||:|       :|:..::             .|..|.|...:...|:|.::.
Mouse  1231 HPMASESGSSESMLHFTSVPILDISPSKVHSTPLQGLTVPHSSKKFSEQGLLKSKSPQQVLPSLF 1295

  Fly   950 KNTEI-------TLQGLRPYHNYTF-TVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAP 1006
            .|.|.       ..|...|...:.| |.|:.....|.|....:..|..:.||..||.:.:.||..
Mouse  1296 SNDEFFQSAHLDVSQAYPPKGRHAFVTPVLSIDEPQNTLINKLVYSEDIFSSTEISITDKVLTGL 1360

  Fly  1007 P------------------GKVDYFQPSDVQPGEVTFEWSLEPAEQHGPI--------------- 1038
            |                  |.:.....|..:...||....|.|:.....:
Mouse  1361 PTLASDVLSSTDHSVPLGSGPISLTMVSPNRDDSVTTAKLLLPSTATSKLTQSARSDADLVGGGE 1425

  Fly  1039 ---DYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQT-- 1098
               ||      :.||..|:....||||                   :..|.|.|...||.:..
Mouse  1426 DGDDY------DDDDYDDIDRGRFPVN-------------------KCMSCLPYRESREKVMNDS 1465

  Fly  1099 --------------MPILAPPVPEPS----VTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTII 1145
                          .|:|.....|.:    ||.::.|...|.:..:...
Mouse  1466 DTQESSLVDQSDPISPLLFENTEEENGGTGVTRVDKSPPPSMLPQNHND---------------- 1514

  Fly  1146 IAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNP------FLTS---NGSRKSSLEA----- 1196
                 ||..|.::|.|              |:.|:.|      .|||   :||.:.:.::
Mouse  1515 -----GKEDSDIQMGS--------------AVLPHTPGSKAWAVLTSDEESGSGQGTSDSLNDNE 1560

  Fly  1197 -----------EHFTIGTANCDKHQAGYCNGPLRAGT---TYRIKIRAFTDEDKFTDTVYSSPI- 1246
                       |..|.|....|  ..|...|..|:.|   |......:.:.|.:.:::.:.|.|
Mouse  1561 TSTDFSFPDVNEKDTDGVLETD--DTGIAPGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIG 1623

  Fly  1247 -----TTERSDTV--IVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYIT 1304
                 .:|:...:  ::.:.::.:.||.:|.:::|.       |:..:.|....|....|....|
Mouse  1624 LAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYW-------RKCFQTAHFYLEDNTSPRVIST 1681

  Fly  1305 PNRPVH----------VKDFSEHYRIMSADSDFRFSEEFEELKHVGRD-QACS--------FANL 1350
            |..|:.          :|.|.:|...:.|.:.  |:||||.||...:: |:|:        .:|.
Mouse  1682 PPTPIFPISDDIGAIPIKHFPKHVADLHASNG--FTEEFETLKEFYQEVQSCTADLGITADSSNH 1744

  Fly  1351 PCNRPKNRFTNILPYDHSRFKLQPVDDDDG--SDYINANYMPGHNSPREFIVTQGPLHSTREEFW 1413
            |.|:.|||:.||:.|||||.||..:.:.||  :|||||||:.|:|.|:.:|..||||.||.|:||
Mouse  1745 PDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFW 1809

  Fly  1414 RMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDI-----KVQLIIDTHYHDWSISEFM 1473
            ||.||.|...|||:|...||||.|||||||.|. :..||..     .||::......::::....
Mouse  1810 RMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDG-SEEYGSFLVNQKSVQVLAYYTVRNFTLRNTK 1873

  Fly  1474 VSRNCE-----------SRIMRHFHFTTWPDFGVPEPPQSLVRFVR----AFRDVIGTDMRPIIV 1523
            :.:..|           .|::..:|:|.|||.||||....::.|||    |.|..:|    |::|
Mouse  1874 LKKLSELFQGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKAAQAKRHAVG----PVVV 1934

  Fly  1524 HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGK 1588
            ||||||||:||:|.||.:||.|.....|:|||.:..:|.:|.::||||:|||.||..|:..:..|
Mouse  1935 HCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK 1999

  Fly  1589 EHLLADSLELHANDGYEVT--------KIYLERQPQTKMGTLPIRASLAMAEKLDADLMT 1640
            |..:.|| .:|:   |..|        |..||:|.|.          |:.:..|.:|..|
Mouse  2000 ETEVPDS-HIHS---YVNTLLIPGPTGKTKLEKQFQL----------LSQSNILQSDYST 2045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	23/139 (17%)
		fn3	247..328	CDD:278470	18/80 (23%)
		fn3	343..417	CDD:278470	22/122 (18%)
		fn3	443..525	CDD:278470	21/116 (18%)
		FN3	548..611	CDD:238020	13/81 (16%)
		FN3	620..706	CDD:238020	14/112 (13%)
		fn3	708..796	CDD:278470	21/111 (19%)
		fn3	824..886	CDD:278470	15/92 (16%)
		fn3	902..978	CDD:278470	20/111 (18%)
		fn3	1013..1092	CDD:278470	17/96 (18%)
		UP_III_II	1106..>1248	CDD:297589	30/179 (17%)
		PTPc	1329..1582	CDD:214550	121/283 (43%)
		PTPc	1355..1582	CDD:238006	109/248 (44%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396	4/16 (25%)
		fn3	313..395	CDD:365830	17/93 (18%)
		PTP_DSP_cys	1714..1997	CDD:391942	122/287 (43%)
		R-PTP-Z-2	2080..2283	CDD:350507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940