DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and Ptprs

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_006523937.1	Gene:	Ptprs / 19280	MGIID:	97815	Length:	1920	Species:	Mus musculus

Alignment Length:	1812	Identity:	417/1812 - (23%)
Similarity:	650/1812 - (35%)	Gaps:	491/1812 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALP 122
            ||.:||    ||....|               |.|..|| |||.       .|:|..:|   .:.
Mouse   113 VGEITI----HAKLTVL---------------REDQLPP-GFPN-------IDMGPQLK---VVE 147

  Fly   123 GTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLS--VQLRSSKSAFITWRPPGSGRYSGFRIR 185
            .|.....|...:.....::||..:.... ||.|:..  .||||......:......|:|......
Mouse   148 RTRTATMLCAASGNPDPEITWFKDFLPV-DPSASNGRIKQLRSGALQIESSEETDQGKYECVATN 211

  Fly   186 VLGLTDLPFERSYSLEGNETLQLSAK--------ELTPGGSYQVQAYSVYQGKESVAYTSRNFTT 242
            ..|:........|..|..|..:::.:        |:.|||:..:...:|
Mouse   212 SAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAV---------------- 260

  Fly   243 KPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFK 307
              .:|..::.|.:....|                    ||:|.:           |.|
Mouse   261 --GSPMPYVKWMQGAEDL--------------------TPEDDM-----------PVG------- 285

  Fly   308 GLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDE----------AYTTSSSFRVRW 362
                   .|:...|..:|..:........|.|.|.|..:|...          ...|::|..|.|
Mouse   286 -------RNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPVVTENTATSITVTW 343

  Fly   363 E----PPRTY--------SEFDAYQVM--LSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVV 413
            :    .|.:|        |:...||:.  ::|:|      .:..|          |.|...||:.
Mouse   344 DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR------YSIGG----------LSPNSEYEIW 392

  Fly   414 VKTIADNVNSWPASGEVTLR---------PRPV--RSLGGFLDDRSNALHISW-EPAE-TGRQDS 465
            |..: :::...|.|..|..|         ||.|  |.|.      :..:.:.| ||.| .|....
Mouse   393 VSAV-NSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS------ATTMIVQWEEPVEPNGLIRG 450

  Fly   466 YRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSK---GVASNASDI 527
            ||:.|     ..|...|.....:..:..:|.. |:.|||....|.:.|.|.:.   |..|:...:
Mouse   451 YRVYY-----TMEPEHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQV 509

  Fly   528 -TRYTRPAAP--LIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNE--TSLTI 587
             |:...|..|  |..|.:| :..:.|||.:.......:||:.: |.|.|......|.:  |:..:
Mouse   510 KTQQGVPGQPMNLRAEAKS-ETSIGLSWSAPRQESVIKYELLF-REGDRGREVGRTFDPTTAFVV 572

  Fly   588 HYLHPGSGYEVKVHAIS-HG-------VRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP- 643
            ..|.|.:.|..::.|.| .|       ||...   .||....|||::...::.:..:::.|:.|
Mouse   573 EDLKPNTEYAFRLAARSPQGLGAFTAVVRQRT---LQAKPSAPPQDVKCTSLRSTAILVSWRPPP 634

  Fly   644 ---EGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNV 705
               .......|.||||                                   ..|.|.|.|.|:|
Mouse   635 PETHNGALVGYSVRYR-----------------------------------PLGSEDPDPKEVN- 663

  Fly   706 TMPPQPVSNVVPLVDSRNLTLEW--------------PRPDGHVDFYTLKWWP----TDEEDRVE 752
            .:||.....::..::      :|              |.|:..         |    |||:....
Mouse   664 NIPPTTTQILLEALE------KWTEYRVTAVAYTEVGPGPESS---------PVVVRTDEDVPSA 713

  Fly   753 FKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGH 817
            .....:.|.|::.::|:.....:||||:        ..||....|             ::...|.
Mouse   714 PPRKVEAEALNATAIRVLWRSPTPGRQH--------GQIRGYQVH-------------YVRMEGA 757

  Fly   818 EQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKD------KEKLANDTERKLSFSGLTPGKLY 876
            |                          :.|.|.|||      :.::.:..|.::..:.|.|...|
Mouse   758 E--------------------------ARGPPRIKDIMLADAQWEMDDTAEYEMVITNLQPETAY 796

  Fly   877 NVTV--WTVSG-GVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTD----FELQY 934
            ::||  :|:.| |..|.|...:.:...|....|...|.....:...|..||....|    :.||:
Mouse   797 SITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPADAAEDPVLGYRLQF 861

  Fly   935 LSADEEAPQLLQNVTKNTEITLQGLRPYH---NYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPI 996
             ..::.||..|:.........    .|.|   .|.|.:..|..:..|.:.|   .:..:...||
Mouse   862 -GREDAAPATLELAAWERRFA----APAHKGATYVFRLAARGRAGLGEEAA---AALSIPEDAP- 917

  Fly   997 SASYQTLTAPPGKVDYFQPSDVQPGEVTFEW-SLEPAEQHGPIDYFRITCQNADDAADVSSYEFP 1060
             ..:..:....|        :|..|.|...| ...|||::|.|..:.::.:.|......:..|..
Mouse   918 -RGFPQILGAAG--------NVSAGSVLLRWLPPVPAERNGAIIKYTVSVREAGAPGPATETELA 973

  Fly  1061 VNATQG-----KIDGLVPGNHYIFRIQAKSALG---------YGAEREHI-----------QTMP 1100
            ..|..|     .:.||.|...|..|::|.:..|         |...|:.:           :|..
Mouse   974 AAAQPGAETALTLRGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARDPVSPKNFKVKMIMKTSV 1038

  Fly  1101 ILAPPVPE--PSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQ 1163
            :|:...|:  .|.||.::.....|:::..|.......|....::...:..:.|.:..||:    |
Mouse  1039 LLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQ----Q 1099

  Fly  1164 DVQAYT----------------------VWLP--YQAIEPYNPFLTSNGSRKS------------ 1192
            .|.|.|                      |:||  ...:...|.|:.....|||
Mouse  1100 TVTARTAFNMLSGKPSVAPKPDNDGFIVVYLPDGQSPVTVQNYFIVMVPLRKSRGGQFPVLLGSP 1164

  Fly  1193 ------------------------SLE------AEHFTIGTA----NCDKHQAGYCNGPLRAGTT 1223
                                    .||      |..|:|..|    ...|...|:.|..|..|..
Mouse  1165 EDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHPGNQKQYGGFDNRGLEPGHR 1229

  Fly  1224 YRIKIRAF--TDEDKFTDTVYSSPITTERSDTV-----------IVAATVSAVLLVAMVLVVVYC 1275
            |.:.:.|.  .:|..|..:.:|.|...:..|..           ::...::.|.::.:|:.::..
Mouse  1230 YVLFVLAVLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLY 1294

  Fly  1276 QHRCQLIRRASK-----------LA--RMQDELAALPEGYITP----NRPVHVKDFSEHYRIMSA 1323
            :::....|:.|:           ||  ..:|.:......:.||    :.|:.:.|.:||...:.|
Mouse  1295 KNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKA 1359

  Fly  1324 DSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANY 1388
            :...:.|:|:|.: ..|:......:||..|:||||:.|::.|||||..|||::...|||||||||
Mouse  1360 NDSLKLSQEYESI-DPGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANY 1423

  Fly  1389 MPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGD 1453
            :.|:.....:|.|||||..|..:||||.||..|..:||:||..||.|.||||||| :|....||.
Mouse  1424 VDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWP-NRGTETYGF 1487

  Fly  1454 IKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT 1516
            |:|.|:.......:.:..|.:.:|  .|.|.:|||.||.|||.||||.|...:.|:|..:.....
Mouse  1488 IQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPP 1552

  Fly  1517 DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581
            |..||:|||||||||:|.||.:|.:|:.|.....||::|.|..||.:|.:|||||.||..||:.|
Mouse  1553 DAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEAL 1617

  Fly  1582 L-AVLEGKEHLLADSLELH------ANDGYEVTKIYLE--RQPQTKMGTLP-IRASL 1628
            | ||..|...:.|.||..:      ...|..||.:.||  |...:|..|.. |.|||
Mouse  1618 LEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAHTSRFITASL 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	18/100 (18%)
		fn3	247..328	CDD:278470	11/80 (14%)
		fn3	343..417	CDD:278470	19/97 (20%)
		fn3	443..525	CDD:278470	20/86 (23%)
		FN3	548..611	CDD:238020	18/72 (25%)
		FN3	620..706	CDD:238020	16/89 (18%)
		fn3	708..796	CDD:278470	18/105 (17%)
		fn3	824..886	CDD:278470	13/70 (19%)
		fn3	902..978	CDD:278470	16/82 (20%)
		fn3	1013..1092	CDD:278470	21/93 (23%)
		UP_III_II	1106..>1248	CDD:297589	39/215 (18%)
		PTPc	1329..1582	CDD:214550	117/254 (46%)
		PTPc	1355..1582	CDD:238006	110/228 (48%)
Ptprs	XP_006523937.1	I-set	33..124	CDD:400151	6/14 (43%)
		Ig strand A	33..36	CDD:409353
		Ig strand A'	42..45	CDD:409353
		Ig strand B	50..57	CDD:409353
		Ig strand C	63..68	CDD:409353
		Ig strand C'	71..73	CDD:409353
		Ig strand D	80..84	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	103..111	CDD:409353
		Ig strand G	114..124	CDD:409353	5/13 (38%)
		IgI_2_RPTP_IIa_LAR_like	137..226	CDD:409400	18/92 (20%)
		Ig strand B	152..156	CDD:409400	0/3 (0%)
		Ig strand C	165..169	CDD:409400	1/3 (33%)
		Ig strand E	190..194	CDD:409400	0/3 (0%)
		Ig strand F	204..209	CDD:409400	1/4 (25%)
		Ig strand G	216..219	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401	21/143 (15%)
		Ig strand B	253..257	CDD:409401	0/3 (0%)
		Ig strand C	266..270	CDD:409401	0/3 (0%)
		Ig strand E	287..291	CDD:409401	1/3 (33%)
		Ig strand F	299..304	CDD:409401	0/4 (0%)
		Ig strand G	312..315	CDD:409401	1/2 (50%)
		FN3	323..412	CDD:238020	20/105 (19%)
		FN3	419..511	CDD:238020	25/103 (24%)
		FN3	516..604	CDD:238020	23/89 (26%)
		FN3	612..706	CDD:238020	22/144 (15%)
		FN3	714..819	CDD:238020	28/151 (19%)
		FN3	929..1017	CDD:238020	20/87 (23%)
		FN3	1022..1105	CDD:238020	15/86 (17%)
		PTP_tm	<1211..1295	CDD:408631	14/83 (17%)
		R-PTPc-S-1	1342..1623	CDD:350473	126/282 (45%)
		R-PTP-S-2	1625..1914	CDD:350475	15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940