Protein Alignment Ptp4E and Ptprm

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001344554.1
• Gene: Ptprm / 19274
• MGIID: 102694
• Length: 1486
• Species: Mus musculus
• Alignment Length: 1222
• Identity: 295/1222 - (24%)
• Similarity: 443/1222 - (36%)
• Gaps: 373/1222 - (30%)

  Fly   595 GY----EVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRY 655
            ||    ||||  :.|.....||.            |.:|.|..|       |.:.:.|....:.
Mouse   168 GYLAIDEVKV--LGHPCTRTPHF------------LRIQNVEVN-------AGQFATFQCSAIG- 210

  Fly   656 RTDASPWQRISGLHENEARIKDMHY--GERYLVQVNTVSF----------------GVESPHPLE 702
            ||.|.....:.|:...:|.:|::..  ..|::...|.|:.                ||...:..|
Mouse   211 RTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMICTEGGVGISNYAE 275

  Fly   703 LNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSV 767
            |.|..||.|::  .|.:.|...|..|
Mouse   276 LVVKEPPVPIA--PPQLASVGATYLW--------------------------------------- 299

  Fly   768 RIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPT 832
                            :|.::|.|....        |::..:|....|.......:
Mouse   300 ----------------IQLNANSINGDG--------PIVAREVEYCTASGSWNDRQ--------- 331

  Fly   833 PADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASL-PVQRLY 896
            |.|||.   |:....||          |||.::|.....||:          ||..|. |..|..
Mouse   332 PVDSTS---YKIGHLDP----------DTEYEISVLLTRPGE----------GGTGSPGPALRTR 373

  Fly   897 RLHPLPI---SDLKAIQVAAREITLHWTAPAGEYT-------DFELQY---LSADEEAPQLLQNV 948
            .....|:   ..|:.::|.:|:||:.| .|.| |.       :..:.|   :...|:..:.:...
Mouse   374 TKCADPMRGPRKLEVVEVKSRQITIRW-EPFG-YNVTRCHSYNLTVHYGYQVGGQEQVREEVSWD 436

  Fly   949 TKNT--EITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAP----- 1006
            |.|:  :.|:..|.||.|                   |||..::.:......| |.||..
Mouse   437 TDNSHPQHTITNLSPYTN-------------------VSVKLILMNPEGRKES-QELTVQTDEDL 481

  Fly  1007 PGKVDYFQPSDVQPG-----EVTFEWSLEPAEQHGPIDYFRIT---CQNADDAADVSSYEFPV-- 1061
            ||.|    |::...|     ::..:|. ||.:.:|.|..:.||   ..:.|...|:|:....|
Mouse   482 PGAV----PTESIQGSAFEEKIFLQWR-EPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSK 541

  Fly  1062 --NATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSV-TPLEVSRTSSTI 1123
              |.|.....||.||..|.|.|:|.:|.|:|....:..|..|.||.:|.... |||  ::|.:|:
Mouse   542 LGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYEFETPL--NQTDNTV 604

  Fly  1124 EISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNP--FLTS 1186
            .:..:......|  .|..|.|::.|:..:...    .:.:.::.|.|.:.:|.....|.  :..:
Mouse   605 TVMLKPAQSRGA--PVSVYQIVVEEERPRRTK----KTTEILKCYPVPIHFQNASILNSQYYFAA 663

  Fly  1187 NGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYR-------------------------- 1225
            .....|...|:.||||.   :|...||.|.||....:||
Mouse   664 EFPADSLQAAQPFTIGD---NKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVRVATKAAI 725

  Fly  1226 ---------IKIRAFTDEDKFTDTVYSSPI---TTERSDTVIVAATVSAVLLVAMVLVVVYCQHR 1278
                     |:|.....:.:.|..|...|:   ..:...||.:|..::.:||..::.:.|.
Mouse   726 IVTQLTTPYIRIAPAAGDGQLTGAVTPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVV---- 786

  Fly  1279 CQLIRRASKLARMQDEL------------------------------------------------ 1295
              |:.:..|||:.:.|.
Mouse   787 --LVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMGTHNLNGRSVSSPSS 849

  Fly  1296 ---------AALPEGYI-TPNRP-----------------------------------------V 1309
                     .::|..|. .|..|                                         :
Mouse   850 FTMKTNTLSTSVPNSYYPDPFVPTAILDETHTMASDTSSLAQPHTYKKREAADVPYQTGQLHPAI 914

  Fly  1310 HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP 1374
            .|.|..:|...|.....:.|.||:|.. ..|:......|....||.|||:.||:.|||||.:||.
Mouse   915 RVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQM 978

  Fly  1375 VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439
            ::.|:.|||||.||:.|::.|..:|.||||:..|..:||||.|..|:.:|:|:|...|.||.||.
Mouse   979 LEGDNNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCC 1043

  Fly  1440 QYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQS 1502
            :|||.|  ...|.||||.||......::.|..|.|.:.  .|.|.:|.||||.|||.|||.....
Mouse  1044 KYWPDD--TEIYKDIKVTLIDTELLAEYVIRTFAVEKRGIHEIREIRQFHFTGWPDHGVPYHATG 1106

  Fly  1503 LVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFM 1567
            |:.|||..:.....:..|::||||||.||:|.||.:|.:|....:...|||:..|..:|..||.|
Mouse  1107 LLGFVRQVKSKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNM 1171

  Fly  1568 VQTEQQYVCIHQCLL-AVLEGKEHLLADSL-ELHANDGYEVTKIYLERQPQT 1617
            ||||:|||.||..:| |.|.|...:.|..: .|:    |::.|:    .|||
Mouse  1172 VQTEEQYVFIHDAILEACLCGDTSIPASQVRSLY----YDMNKL----DPQT 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	36/175 (21%)
		fn3	708..796	CDD:394996	10/87 (11%)
		fn3	902..978	CDD:394996	19/90 (21%)
		fn3	1013..1092	CDD:394996	26/90 (29%)
		PTP_tm	1127..1247	CDD:465889	28/159 (18%)
		R3-PTPc	1358..1579	CDD:350396	101/222 (45%)
Ptprm	NP_001344554.1	MAM	22..182	CDD:214533	7/15 (47%)
		ig	192..274	CDD:395002	16/89 (18%)
		FN3	<266..>638	CDD:442628	106/503 (21%)
		fn3	499..574	CDD:394996	24/75 (32%)
		R-PTPc-M-1	918..1190	CDD:350481	117/274 (43%)
		R-PTPc-M-2	1276..1481	CDD:350483