DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprj

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_006499054.1	Gene:	Ptprj / 19271	MGIID:	104574	Length:	1351	Species:	Mus musculus

Alignment Length:	1597	Identity:	390/1597 - (24%)
Similarity:	624/1597 - (39%)	Gaps:	411/1597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 PPANLSVQLR---------------SSKSAFITWRPPGSG----RYSGFRIRVLGLTDLPFERSY 198
            ||......||               ::.:|.::...||:|    |.:|:|.|
Mouse    30 PPREAPASLRPRPLRARRARLRRVAAAAAAAMSPGKPGAGGAGTRRTGWRRR------------- 81

  Fly   199 SLEGNETLQLSAKELTPG-GSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLL- 261
                ....:|..:...|| |....:....:||.:.:...:|...|.|.:||  :.|......||
Mouse    82 ----RRRRRLETETRAPGFGHTAGRVPGTFQGAQGMKPAARETRTPPRSPG--LRWALLPLLLLL 140

  Fly   262 ----VLWQPPFPAGIYTHYRVSITP---------DDAIQSVLYVEREGEP----PGPAQAA--FK 307
                ||.....|..|:....| ::|         :|:..|...:|.:.|.    |...|.:  ..
Mouse   141 RQGQVLCAGAAPNPIFDIEAV-VSPTSVLLTWKHNDSGASECRIENKMESNLTFPVKNQTSCNIT 204

  Fly   308 GLVPGREYNISVQTVSEDETSSVPTTARYLTVPE-RVLNVTFDEAYTT------SSSFRVRWEPP 365
            ||.||..|..|:.:|:.:||.:...|.....|.: .|.:|...:|..|      ::|:|:..|..
Mouse   205 GLSPGTSYTFSIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEEL 269

  Fly   366 RTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEV 430
            .|:|.              .|:.....|.:..|.:|:..|....:.|..:..||      |:|..
Mouse   270 TTHSS--------------VNISGLKPGTNNSFAFPESNETQADFAVAEEVPAD------ANGTK 314

  Fly   431 TLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNL 495
            .:   ||.:|...   ..|:| :|.:| .:|:..|                             |
Mouse   315 RI---PVTNLSQL---HKNSL-VSVDP-PSGQDPS-----------------------------L 342

  Fly   496 TEYTLDSLLAGRRY--LIAVQAL--SKGVASNASDITRYTRPAAPLIQELRSID---QGLMLSWR 553
            ||..|..|....:|  .|..||.  ::|...|....|..|:     :.::|:::   ..:.|:|:
Mouse   343 TEILLTDLKPDTQYNATIYSQAANGTEGQPRNKVFKTNSTQ-----VSDVRAMNISASSMTLTWK 402

  Fly   554 SDVNSRQDR--YEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQ 616
            |:.:..:..  |::|..  |.........|:|...|..|...:.|.:.||.........|.  |.
Mouse   403 SNYDGSRTSIVYKIHVA--GGTHSVNQTVNKTEAIILGLSSSTLYNITVHPFLGQTEGTPG--FL 463

  Fly   617 AVFPKPPQ--NLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMH 679
            .|:..|.|  :..:..|.|..:.|.|::.:...|..::   :.|.....|.:........::|:.
Mouse   464 QVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFI---KQDGGEKHRNASTGNQSYMVEDLK 525

  Fly   680 YGERYLVQVNTVSFGVESPHPLE--LNVTMPPQPVSNV-VPLVDSRNLTLEWPRPDGHVDFYTLK 741
            .|..|..::  :..|.:....|.  :|.:..|..|::: |..:.:..:.|||..
Mouse   526 PGTSYHFEI--IPRGPDGTEGLSSTVNGSTDPSAVTDIRVVNISTTEMQLEWQN----------- 577

  Fly   742 WWPTDEEDRVEFKNVTQLEDLSSPSVR-------IPIEDLSPGRQYRF-------EVQASSNGIR 792
               ||:.....:..|  ||..|...:|       |.:..|:||..|..       ::|..||.|.
Mouse   578 ---TDDASGYTYHLV--LESKSGSIIRTNSSQKWITVGSLTPGTLYNVTIFPEVDQIQGISNSIT 637

  Fly   793 -----SGTTHL----STRTMPLIQSDVFIANAGH-------EQGQDETITLSYTPTPADSTRFDI 841
                 |..:|:    :|.|..:...:...|:|.:       :.|....:|.::|.
Mouse   638 QYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTSNFTK---------- 692

  Fly   842 YRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWT-VSGGVASL-PVQRLYRLHPLPIS 904
                  ||:|...|              |.||..|.|.:.| |..|..|| |...|:...|.|::
Mouse   693 ------DPSILIPE--------------LIPGVSYTVKILTQVGDGTTSLVPGWNLFCTEPEPVT 737

  Fly   905 DLKAIQVAARE--ITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTF 967
            .... :|..:|  :.|.|..|.|.||.|||...|...:....|:|.|.:.:...:....|.|::
Mouse   738 SFHC-EVVPKEPALVLKWACPFGMYTGFELGVRSDSWDNMTRLENCTSDDDTECRTEVAYLNFS- 800

  Fly   968 TVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPA 1032
                       |.: ::|::||
Mouse   801 -----------TSY-NISIATL------------------------------------------- 810

  Fly  1033 EQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQ 1097
                       :|                                     .|.||    ..::|.
Mouse   811 -----------SC-------------------------------------GKMAL----PAQNIC 823

  Fly  1098 TMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSW 1162
            |..|..||.|:.|.....||..|..::.|    .|..:||.:::|.:|:.  .|:.|    .||
Mouse   824 TTGITDPPTPDGSPNITSVSHNSVKVKFS----GFEASHGPIKAYAVILT--TGEAA----QPS- 877

  Fly  1163 QDVQAYTVWLPYQ-----AIEPYNPFL---TSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLR 1219
            .||..||    |:     |.:.|..:|   ...|..:...|..::.|...| .....||.||.|.
Mouse   878 ADVLKYT----YEDFKRGASDTYVTYLIRIEEKGQSQGLSEVLNYEIDVGN-QSTTLGYYNGRLE 937

  Fly  1220 AGTTYRIKIRAFT--------------DEDKFTDTVYSSPITTERSDTVIVAAT----VSAVLLV 1266
            ...:||..:..||              ||...:.:.||..:...:...||..|.    ..|:.:.
Mouse   938 PLGSYRACVAGFTNITYNLQNDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAIT 1002

  Fly  1267 AMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSE 1331
            |:...:.:.:.|..........::::.:.:.|          :.|::|..:::...|||:..|:|
Mouse  1003 AVGGFIFWRKKRTDAKNNEVSFSQIKPKKSKL----------IRVENFEAYFKKQQADSNCGFAE 1057

  Fly  1332 EFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPR 1396
            |:|:||.:|.......|.:..||.|||:.|:||||.||.||. |......||||||||||::|.:
Mouse  1058 EYEDLKLIGISLPKYTAEIAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKK 1121

  Fly  1397 EFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIID 1461
            :||.|||||.:|.::||||.||.|..||||||:|.|:||.||::||| .:.|..||||.|.:..:
Mouse  1122 DFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWP-SKQAQDYGDITVAMTSE 1185

  Fly  1462 THYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRF---VRAFRDVIGTDMRPI 1521
            ....:|:|.:|:|.  :|.||..:|.||||:|||.|||:....|:.|   ||.:...|..: .||
Mouse  1186 VVLPEWTIRDFVVKNMQNSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPE-SPI 1249

  Fly  1522 IVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586
            :|||||||||:|||||:||::..|...:.||::|||:.:|..|..|||||.|||.::||:|.::.
Mouse  1250 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIR 1314

  Fly  1587 GKEHLLADSLELHANDGYEVT---KIYLERQPQTKMG 1620
            .::....|.:       |:.|   .||...:|.:..|
Mouse  1315 AQKDSKVDLI-------YQNTTAMTIYENLEPVSMFG 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	19/108 (18%)
		fn3	247..328	CDD:278470	25/100 (25%)
		fn3	343..417	CDD:278470	15/79 (19%)
		fn3	443..525	CDD:278470	17/85 (20%)
		FN3	548..611	CDD:238020	13/64 (20%)
		FN3	620..706	CDD:238020	15/89 (17%)
		fn3	708..796	CDD:278470	23/107 (21%)
		fn3	824..886	CDD:278470	13/62 (21%)
		fn3	902..978	CDD:278470	18/77 (23%)
		fn3	1013..1092	CDD:278470	4/78 (5%)
		UP_III_II	1106..>1248	CDD:297589	40/163 (25%)
		PTPc	1329..1582	CDD:214550	129/257 (50%)
		PTPc	1355..1582	CDD:238006	119/231 (52%)
Ptprj	XP_006499054.1	fn3	162..222	CDD:365830	14/59 (24%)
		fn3	383..460	CDD:365830	14/83 (17%)
		FN3	469..553	CDD:238020	15/88 (17%)
		FN3	555..622	CDD:214495	18/82 (22%)
		FN3	642..721	CDD:238020	21/108 (19%)
		PTP_tm	831..1014	CDD:376280	46/198 (23%)
		R-PTPc-J	1083..1311	CDD:350463	118/230 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.910