DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprd

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_036019731.1	Gene:	Ptprd / 19266	MGIID:	97812	Length:	1966	Species:	Mus musculus

Alignment Length:	1779	Identity:	422/1779 - (23%)
Similarity:	654/1779 - (36%)	Gaps:	501/1779 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GFPEPNTT-------IPASDIGKDIK--FSRALPGTEYNFWLYYTNSTHREQLTW----TVNITT 149
            |.|:|..|       :..|:....||  .|.::.||.....|....|...:|..:    |.:..|
Mouse   159 GNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGT 223

  Fly   150 APDPPANLSV-QLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKEL 213
            ....||||.| :||..:..     ||   |:|                         :..:..|:
Mouse   224 RYSAPANLYVRELREVRRV-----PP---RFS-------------------------IPPTNHEI 255

  Fly   214 TPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRV 278
            .||||..:...:|                  .:|..::.|......|..  :...|.|     |.
Mouse   256 MPGGSVNITCVAV------------------GSPMPYVKWMLGAEDLTP--EDDMPIG-----RN 295

  Fly   279 SITPDDAIQSVLY----VEREGEPPGPAQAAFKGL--VPGREYNISVQTVSEDETSSVPTTARYL 337
            .:..:|..||..|    :...|.....||...|.|  .||      ...|:|...:|:
Mouse   296 VLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPG------TPVVTESTATSI------- 347

  Fly   338 TVPERVLNVTFDEAYTTSSSFRVRWEPPRT----YSEFDAYQVMLSTSRRIFNVPRAANGDSVYF 398
                   .:|:|.......|:.:....|:.    |.|.|.    ::|:|  ::|.    |.|.|.
Mouse   348 -------TLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDG----IATTR--YSVA----GLSPYS 395

  Fly   399 DYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLR---------PRPV--RSLGGFLDDRSNALH 452
            ||        .:.||.   .:|:...|||..|..:         ||.|  |.|.      |..:.
Mouse   396 DY--------EFRVVA---VNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLS------STTIL 443

  Fly   453 ISW-EPAE-TGRQDSYRISY-------------HEQTNASEVPAPFPVAAESQITTNLTEYTLDS 502
            :.| ||.| .|:...||:.|             |.             .|:||||      |:.:
Mouse   444 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN-------------VADSQIT------TIGN 489

  Fly   503 LLAGRRYLIAVQAL-SKGVASNASDITRYTR---PAAPL-IQELRSIDQGLMLSW---RSDVNSR 559
            |:..:.|.:.|.|. |.|....:|||...|:   |..|| .:.....:..::|||   |||..:
Mouse   490 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIA- 553

  Fly   560 QDRYEVHYQRNGTREERTMATNE--TSLTIHYLHPGSGYEVKVHAIS-------------HGVRS 609
              .||:.| |:|.:.|....|.|  ||..:..|.|.|.|..::.|.|             ..::|
Mouse   554 --SYELVY-RDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQS 615

  Fly   610 EPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP----EGSDFSEYVVRYRT----DASPWQRIS 666
            :|.:        |||:::..:..:..:::.||.|    :....:||.::|..    |..| ..|.
Mouse   616 KPSA--------PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKP-HEIL 671

  Fly   667 GLHENEAR--IKDMHYGERYLVQVNTVSFGVESPHPLELNVTM---------PPQPVSNVVPLVD 720
            |:..:..:  ::.:.....|.:.| |....| .|.|..|:|.:         ||:.|.  |..|:
Mouse   672 GIPSDTTKYLLEQLEKWTEYRITV-TAHTDV-GPGPESLSVLIRTDEDVPSGPPRKVE--VEAVN 732

  Fly   721 SRNLTLEWPRP-----DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIED------- 773
            :..:.:.|..|     .|.:..|.:.:   .:.:..|.|....|:|:.....:...:|
Mouse   733 ATAVKVSWRSPVPNKQHGQIRGYQVHY---VKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI 794

  Fly   774 ---LSPGRQYRFEVQA---SSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPT 832
               |.|...|...|.|   ..:|.||....:|| |..:......:.|    ..|..|..:.:.|
Mouse   795 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVST-TGAVPGKPRLVIN----HTQMNTALIQWHP- 853

  Fly   833 PADS-TRFDIYRFSMGDPTIKDKEKLA----NDTERKLSFSGLTPGKLYNVTVWTVSG----GVA 888
            |.|: .....||...|.   ||.|.|.    ::.|...:.:.:..|..|   |:.:|.    |..
Mouse   854 PVDTFGPLQGYRLKFGR---KDMEPLTTLEFSEKEDHFTATDIHKGASY---VFRLSARNKVGFG 912

  Fly   889 SLPVQRLYRLHPLPI---SDLKAIQVAAREITLHWTAPA-----GEYTDFELQYLSADEEAPQLL 945
            ...|:.:.....:|.   .:|.:....:..:.|.|..|.     |..|.:.|.|  .|...|.|.
Mouse   913 EEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLY--RDINVPLLP 975

  Fly   946 QN---VTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPP 1007
            ..   |..:|.:||.||:  .:.|:.|.||:.:.:|              ..|.|.|.|..|.|.
Mouse   976 MEHLIVPADTSMTLTGLK--SDTTYDVKVRAHTSKG--------------PGPYSPSVQFRTLPV 1024

  Fly  1008 GKVDY---FQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKID 1069
            .:..:   |....|....|...|  |..|.:.....|:|.   .||...|.  |....|||..|.
Mouse  1025 DQAVFAKNFHVKAVMKTSVLLSW--EIPENYNSAMPFKIL---YDDGKMVE--EVDGRATQKLIV 1082

  Fly  1070 GLVPGNHYIF--------------RIQAKSALGYGAEREHIQTMP-------------ILAPPVP 1107
            .|.|...|.|              |:.||:|      .:.::|.|             :..|.||
Mouse  1083 NLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA------PDVLRTKPAFIGKTNLDGMITVQLPDVP 1141

  Fly  1108 EPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWL 1172
                                       |:..::.|.|||..  .|.:.|..:..|:......:
Mouse  1142 ---------------------------ANENIKGYYIIIVP--LKKSRGKFIKPWESPDEMEL-- 1175

  Fly  1173 PYQAIEPYNPFLTSNGSRKSSLE-----------AEHF----TIGTANCDKHQAGYCNGPLRAGT 1222
                    :..|.....::.|:.           |.||    |..|...|||..|:.|..|::|.
Mouse  1176 --------DELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQ 1232

  Fly  1223 TYRIKIRAFTD--EDK------FTDTVYS-----SPITTERSDTVIVAATVSAVLLVAMVLVVVY 1274
            .|...:.|..|  |.|      ::|.|.|     .|||.|....:.|...|.||:.:..:::.:
Mouse  1233 EYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI- 1296

  Fly  1275 CQHRCQLIRRAS----KLARMQDELAALPEGYITPNR---------------------------- 1307
                  |:.::|    |.|..:...::||.....|:.
Mouse  1297 ------LLYKSSKPDRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPALSSNSVPYASL 1355

  Fly  1308 ----------------------------------PVHVKDFSEHYRIMSADSDFRFSEEFEELKH 1338
                                              |:.:.:.::|...:.|:.:.:||:|:|.: .
Mouse  1356 IGSVSSLSSQTTTQSIYDNNSLPRFARKGMASHPPIPILELADHIERLKANDNLKFSQEYESI-D 1419

  Fly  1339 VGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQG 1403
            .|:......:||..|:||||:.|::.|||||..|..::...||||:||||:.|:.....:|.|||
Mouse  1420 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG 1484

  Fly  1404 PLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWS 1468
            .|..|..:||||.||..|..:||:|:..|:.|.||||||| .|....:|.::|.|:.......:.
Mouse  1485 SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYC 1548

  Fly  1469 ISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGR 1531
            :..|.:.:|  .|.|.:|.|.||.|||.||||.|...:.|:|..:.....|..|::|||||||||
Mouse  1549 VRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGR 1613

  Fly  1532 SGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSL 1596
            :|.||.:|.:|:.|.....|||:|.|..||.:|.:|||||.||:.||..||      |.:...:.
Mouse  1614 TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALL------EAVTCGNT 1672

  Fly  1597 ELHANDGYEVTKIYLERQPQTKMG 1620
            |:.|.:.|    .|:::..|.:.|
Mouse  1673 EVPARNLY----AYIQKLTQIETG 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	17/91 (19%)
		fn3	247..328	CDD:278470	19/86 (22%)
		fn3	343..417	CDD:278470	17/77 (22%)
		fn3	443..525	CDD:278470	22/97 (23%)
		FN3	548..611	CDD:238020	23/80 (29%)
		FN3	620..706	CDD:238020	20/95 (21%)
		fn3	708..796	CDD:278470	22/105 (21%)
		fn3	824..886	CDD:278470	16/70 (23%)
		fn3	902..978	CDD:278470	22/86 (26%)
		fn3	1013..1092	CDD:278470	24/92 (26%)
		UP_III_II	1106..>1248	CDD:297589	34/169 (20%)
		PTPc	1329..1582	CDD:214550	109/254 (43%)
		PTPc	1355..1582	CDD:238006	101/228 (44%)
Ptprd	XP_036019731.1	I-set	31..123	CDD:400151
		Ig strand A'	39..43	CDD:409353
		Ig strand B	46..55	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..72	CDD:409353
		Ig strand D	75..83	CDD:409353
		Ig strand E	84..94	CDD:409353
		Ig strand F	102..110	CDD:409353
		Ig strand G	113..123	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400	19/74 (26%)
		Ig strand B	151..155	CDD:409400
		Ig strand C	164..168	CDD:409400	1/3 (33%)
		Ig strand E	198..202	CDD:409400	1/3 (33%)
		Ig strand F	212..217	CDD:409400	0/4 (0%)
		Ig strand G	224..227	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401	20/130 (15%)
		Ig strand B	261..265	CDD:409401	0/3 (0%)
		Ig strand C	274..278	CDD:409401	0/3 (0%)
		Ig strand E	295..299	CDD:409401	0/3 (0%)
		Ig strand F	307..312	CDD:409401	1/4 (25%)
		Ig strand G	320..323	CDD:409401	0/2 (0%)
		FN3	331..420	CDD:238020	27/129 (21%)
		FN3	427..519	CDD:238020	30/116 (26%)
		FN3	524..612	CDD:238020	25/91 (27%)
		FN3	620..714	CDD:238020	21/96 (22%)
		FN3	721..827	CDD:238020	22/110 (20%)
		FN3	832..927	CDD:238020	20/105 (19%)
		FN3	930..1021	CDD:238020	26/108 (24%)
		FN3	1031..>1092	CDD:238020	19/67 (28%)
		R-PTPc-D-1	1388..1671	CDD:350472	115/290 (40%)
		R-PTP-D-2	1672..1963	CDD:350476	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940