Protein Alignment Ptp4E and Ptprc

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001104786.2
• Gene: Ptprc / 19264
• MGIID: 97810
• Length: 1293
• Species: Mus musculus
• Alignment Length: 1199
• Identity: 295/1199 - (24%)
• Similarity: 465/1199 - (38%)
• Gaps: 334/1199 - (27%)

  Fly   746 DEEDRVEFKNVTQLEDLSSP--SVRIPIEDLSPGRQYRF---EVQASSNGIRSGTTH---LSTRT 802
            |.|..|..:..|..::||:.  ::.:|..|..|.|....   .:....||....|.|   ||| .
Mouse    18 DTEVFVTGQTPTPSDELSTTENALLLPQSDPLPARTTESTPPSISERGNGSSETTYHPGVLST-L 81

  Fly   803 MPLI--QSDVFIANAGHEQGQDETITLS-------YTPTPADSTRFDIYRFSMGDP--------- 849
            :|.:  |.|....:||   |.| |.|.|       .||.|...|          ||
Mouse    82 LPHLSPQPDSQTPSAG---GAD-TQTFSSQADNPTLTPAPGGGT----------DPPGVPGERTV 132

  Fly   850 --TIK-------DKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHP----L 901
              ||.       |...||.::      |..:|....||:...:|.|.:      |..|.|    |
Mouse   133 PGTIPADTAFPVDTPSLARNS------SAASPTHTSNVSTTDISSGAS------LTTLTPSTLGL 185

  Fly   902 PISDLKAIQVAAR----------EITLHWTAPAGEYTDFELQYLSAD-----------EEAPQLL 945
            ..:|..:..:|..          .||:::|..:...|      ..||           |:...:|
Mouse   186 ASTDPPSTTIATTTKQTCAAMFGNITVNYTYESSNQT------FKADLKDVQNAKCGNEDCENVL 244

  Fly   946 QNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKV 1010
            .|:.:.::|                           .::|||.  .|.||  |:...|..||| .
Mouse   245 NNLEECSQI---------------------------KNISVSN--DSCAP--ATTIDLYVPPG-T 277

  Fly  1011 DYFQPSDVQPGE-----VTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQG-KID 1069
            |.|...|..|.|     :..||..:..:       || .| |:|:.:.|...| |.|.|:. :.:
Mouse   278 DKFSLHDCTPKEKANTSICLEWKTKNLD-------FR-KC-NSDNISYVLHCE-PENNTKCIRRN 332

  Fly  1070 GLVPGNHYIFRIQAKSALGYGAERE-------------HIQTMPILAPPVPEPSV---------- 1111
            ..:|....:..::|::  .|....|             ::|| .:..|..|:||.
Mouse   333 TFIPERCQLDNLRAQT--NYTCVAEILYRGVKLVKNVINVQT-DLGIPETPKPSCGDPAARKTLV 394

  Fly  1112 -TPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASG--LEMPSWQDVQAYTVWLP 1173
             .|..||:..|.          |..||.|..|         ||.|.  ..:|:  :|.::.|
Mouse   395 SWPEPVSKPESA----------SKPHGYVLCY---------KNNSEKCKSLPN--NVTSFEV--- 435

  Fly  1174 YQAIEPYNPFLTS-----NGSRKSSLEAEHFTIGTA-NCDKHQAG-------------------- 1212
             ::::||..:..|     ||..:.:        ||| .|:.|...
Mouse   436 -ESLKPYKYYEVSLLAYVNGKIQRN--------GTAEKCNFHTKADRPDKVNGMKTSRPTDNSIN 491

  Fly  1213 -YC------NGP-------LRAGTTYRIKIRAFTDEDKFTDTVY------------------SSP 1245
             .|      |||       :|:|.::..|... |:...:.|.:|                  .|.
Mouse   492 VTCGPPYETNGPKTFYILVVRSGGSFVTKYNK-TNCQFYVDNLYYSTDYEFLVSFHNGVYEGDSV 555

  Fly  1246 ITTERSDTVIVAATVSAVLLVAM----VLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPN 1306
            |..|.::....|..:..|.|:.:    :|||:|..:..:. :|:|.|...|:.:....|..:...
Mouse   556 IRNESTNFNAKALIIFLVFLIIVTSIALLVVLYKIYDLRK-KRSSNLDEQQELVERDDEKQLMDV 619

  Fly  1307 RPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFK 1371
            .|:|.....|.|:...||....|..||:.:..|........|..|.|:.|||:.:|||||::|.:
Mouse   620 EPIHSDILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVE 684

  Fly  1372 LQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGRE 1436
            |..::.|.||.||||:|:.|...||::|..|||...|.::||||.||..:..|||:|||.|..|.
Mouse   685 LSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRN 749

  Fly  1437 KCDQYWP-VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE---SRIMRHFHFTTWPDFGVP 1497
            ||.:||| ::.....:.||.|.:.......|:.|.:..|:...|   .|.:.|..||:|||.|||
Mouse   750 KCAEYWPSMEEGTRAFKDIVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVP 814

  Fly  1498 EPPQSLV---RFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFA 1559
            |.|..|:   |.|.||.:...   .||:|||||||||:||:|.:|.:|:.:.....||::|.|..
Mouse   815 EDPHLLLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVK 876

  Fly  1560 MRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPI 1624
            :|::|..|||.|.||:.|||.|:      |:......|::.::.:.......:|.|.:...  |:
Mouse   877 LRRQRCLMVQVEAQYILIHQALV------EYNQFGETEVNLSELHSCLHNMKKRDPPSDPS--PL 933

  Fly  1625 RAS---LAMAEKLDADLMTNKDEDEDQEQQQQ------QQLQLATEVKPKGSNDDEEDEEDDDDD 1680
            .|.   |..........:.|::|::.:.:...      .::.|..|::....::.|.||..|||.
Mouse   934 EAEYQRLPSYRSWRTQHIGNQEENKKKNRNSNVVPYDFNRVPLKHELEMSKESEPESDESSDDDS 998

  Fly  1681 DDDQQPLNNETTATLSSASCSSSTHDVHVVLQEAIEKPKQE------------------------ 1721
            |       :|.|:...:||...|.....:::  |.:.|.:|
Mouse   999 D-------SEETSKYINASFVMSYWKPEMMI--AAQGPLKETIGDFWQMIFQRKVKVIVMLTELV 1054

  Fly  1722 --QERICA-----GTQSHADTESDNTDSD 1743
              .:.:||     |.|::.|.|.:..|::
Mouse  1055 NGDQEVCAQYWGEGKQTYGDMEVEMKDTN 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	1/2 (50%)
		fn3	708..796	CDD:394996	12/54 (22%)
		fn3	902..978	CDD:394996	12/96 (13%)
		fn3	1013..1092	CDD:394996	19/84 (23%)
		PTP_tm	1127..1247	CDD:465889	32/179 (18%)
		R3-PTPc	1358..1579	CDD:350396	96/227 (42%)
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:403599	4/12 (33%)
		DUF5585	<19..>181	CDD:465521	45/188 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..174		38/151 (25%)
		CD45	212..265	CDD:432641	12/87 (14%)
		FN3	393..451	CDD:238020	18/82 (22%)
		FN3	474..553	CDD:238020	10/79 (13%)
		R-PTPc-C-1	696..896	CDD:350405	85/202 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	980..1003		8/29 (28%)
		R-PTP-C-2	1006..1211	CDD:350406	13/80 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1240..1293