DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprb

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_036011586.1	Gene:	Ptprb / 19263	MGIID:	97809	Length:	2361	Species:	Mus musculus

Alignment Length:	1745	Identity:	504/1745 - (28%)
Similarity:	772/1745 - (44%)	Gaps:	268/1745 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QNSQQQQKHFVWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFG--------FP 100
            :||::.|...|.|.|..|.:   :|||...|               .|.:..|.|        ..
Mouse   744 RNSERCQGRTVPLAVLQLRV---KHANETSL---------------GITWRAPLGEWEKYIISLM 790

  Fly   101 EPNTTIPASDIGKDIK---FSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLR 162
            :....:....:.||.|   |:..:||..|...:  |:.:...:.:.::...|.|....:|.|..:
Mouse   791 DRELLVIHKSLSKDAKEFTFTDLMPGRNYKATV--TSMSGDLKQSSSIKGRTVPAQVTDLHVNNQ 853

  Fly   163 S-SKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGN----------ETLQLSAKELTPG 216
            . :.|.|..|            .:.||  |:.|.:...:..|          :|.:.|.:.|.||
Mouse   854 GMTSSLFTNW------------TKALG--DVEFYQVLLIHENVVVKNESVSSDTSRYSFRALKPG 904

  Fly   217 GSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSIT 281
            ..|.|...:|..|..|....:...|...:..|..:........|.|.|.|  ..|...||.||::
Mouse   905 SLYSVVVTTVSGGISSRQVVAEGRTVPSSVSGVTVNNSGRNDYLSVSWLP--APGEVDHYVVSLS 967

  Fly   282 PDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNV 346
            .:..:...|.:.:     ..::.:|..|.|||.||::|.|.|.:..|...|..|  |||::|..:
Mouse   968 HEGKVDQFLIIAK-----SVSECSFSSLTPGRLYNVTVTTKSGNYASHSFTEER--TVPDKVQGI 1025

  Fly   347 TFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIF----NVPRAANGDSVYFDYPDILEPG 407
            :...: ..|...:|.|  .....:||.|:|.:. :|..|    .:|::.| :..:.:    |.||
Mouse  1026 SVSNS-ARSDYLKVSW--VHATGDFDHYEVTIK-NRESFIQTKTIPKSEN-ECEFIE----LVPG 1081

  Fly   408 RTYEVVVKTIADNVNSWPASGEVTLR--PRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISY 470
            |.|.|.|.|   ....:.||.:.|.|  |.||:.| ..|:..:..||::|..| .|..|.|.:..
Mouse  1082 RLYSVTVST---KSGQYEASEQGTGRTIPEPVKDL-TLLNRSTEDLHVTWSRA-NGDVDQYEVQL 1141

  Fly   471 HEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAA 535
              ..|..:|   ||   ...:....|||...:|..||.|.|.|..:|..|..:|. |...|.|:.
Mouse  1142 --LFNDMKV---FP---HIHLVNTATEYKFTALTPGRHYKILVLTISGDVQQSAF-IEGLTVPST 1197

  Fly   536 PLIQELRSIDQG----LMLSWR---SDVNSRQDRYEVH-YQRNGTREERTMATNETSLTIHYLHP 592
              ::.:.....|    ||::|.   .||    |.|.|. ::::...:.:|:..:.:..|.|.|..
Mouse  1198 --VKNIHISANGATDRLMVTWSPGGGDV----DSYVVSAFRQDEKVDSQTIPKHASEHTFHRLEA 1256

  Fly   593 GSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVH-TNLVVLHWQAPEGSDFSEYVVRYR 656
            |:.|.:.:.::|..:|::..:..|.| |...|.:.....: :|.:.:.||...|       |..|
Mouse  1257 GAKYRIAIVSVSGSLRNQIDALGQTV-PASVQGVVAANAYSSNSLTVSWQKALG-------VAER 1313

  Fly   657 TDASPWQRISGLHEN--------------EARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTM 707
            .|      |..|:||              :.:.:|:..|::|.:|:.|||.|:.|........|:
Mouse  1314 YD------ILLLNENGLLLSNVSEPATARQHKFEDLTPGKKYKMQILTVSGGLFSKESQAEGRTV 1372

  Fly   708 PPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDE--EDRVEFKNVTQLEDLSSPSVRIP 770
            |....:..:....||.|:..|...:|.:.:|.:..:..|.  ::|.:...:.|         ...
Mouse  1373 PAAVTNLRITENSSRYLSFGWTASEGELSWYNIFLYNPDRTLQERAQVDPLVQ---------SFS 1428

  Fly   771 IEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETIT----LSYTP 831
            .::|..||.|:. |..:.:|..|..:.:..||:|        |...|.:|.....|    .|::|
Mouse  1429 FQNLLQGRMYKM-VIVTHSGELSNESFIFGRTVP--------AAVNHLKGSHRNTTDSLWFSWSP 1484

  Fly   832 TPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLY 896
            ...|   ||.|...:.:|....||........:..|.||.||:.|.:.|.|.||.::: .|....
Mouse  1485 ASGD---FDFYELILYNPNGTKKENWKEKDVTEWRFQGLVPGRKYTLYVVTHSGDLSN-KVTGEG 1545

  Fly   897 RLHPLPISDLKAIQVAAREITLHWTAPAG--EYTDFELQYLSADEEAPQLLQNVTKNTEITLQGL 959
            |..|.|.|.|....||...:.:.|..|..  :|.|||||:...|........:..|:....:.||
Mouse  1546 RTAPSPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWFPGDALTIFNPYSSRKSEGRIVYGL 1610

  Fly   960 RPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVT 1024
            .|..:|.|:|...||....|            .|.|||.|.:|   .|.|:............:.
Mouse  1611 HPGRSYQFSVKTVSGDSWKT------------YSKPISGSVRT---KPDKIQNLHCRPQNSTAIA 1660

  Fly  1025 FEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGK----IDGLVPGNHYIFRIQAKS 1085
            ..| :.|   ....|.:.|.|:.    .|....||.....:.|    |..|||...|:..|:.:|
Mouse  1661 CSW-IPP---DSDFDGYSIECRK----MDTQEIEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQS 1717

  Fly  1086 ALGYGAEREHIQTMPIL-APPVPEP--SVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIA 1147
            | |..:|.....|:.:: .||.|.|  .|...:|..:.|:|..:....:||:.:|.|:.:.:::.
Mouse  1718 A-GMTSEVVEDSTITMIDRPPQPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFAVVVR 1781

  Fly  1148 E----DVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTS-----NGSRKS---SLEAEHFT 1200
            |    |..|......:||:.:.:.......||.    |.|.:.     :.|.||   .|.||..:
Mouse  1782 EADSMDELKPEQQHPLPSYLEYRHNASIRVYQT----NYFASKCAESPDSSSKSFNIKLGAEMDS 1842

  Fly  1201 IGTANCDKHQAGYCNGPLRAGTTYRIKIRAFT---DED--KFT-----DTVYSSPITTERSDTVI 1255
            :| ..||..|..:|:|||:..|.|||.|||||   |||  :||     ||.:|.|||||......
Mouse  1843 LG-GKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSMPITTESEPLFG 1906

  Fly  1256 VAATVSA-VLLVAMVLVVV---YCQHRCQLIRR--ASKLARMQDELAAL-----PEGYITPNRPV 1309
            |...||| :.|:.|::.:|   .|:.:....|.  :::|:..:|...::     .:|....:.|:
Mouse  1907 VIEGVSAGLFLIGMLVALVAFFICRQKASHSRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPI 1971

  Fly  1310 HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP 1374
            .:..|..|:..:.|||::..|:|:|:||.|||.|:|..|.||.||.|||:.||||||.||.||..
Mouse  1972 KINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCN 2036

  Fly  1375 VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439
            ||||..||||||:|:||:|..||:|.|||||..|:::||:|.||.|...|||:|:|.||||.|||
Mouse  2037 VDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCD 2101

  Fly  1440 QYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCES------RIMRHFHFTTWPDFGVPE 1498
            .|||.|:..::|||:.:|::.::...:|:|.||.:   |..      |::||||:|.|||.||||
Mouse  2102 HYWPADQDPLYYGDLILQMVSESVLPEWTIREFKI---CSEEQLDAHRLIRHFHYTVWPDHGVPE 2163

  Fly  1499 PPQSLVRFVRAFRDVIGTD--MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMR 1561
            ..|||::|||..||.|...  ..|.:|||||||||:|||:|||||||.:...|.|||:|.|..:|
Mouse  2164 TTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLR 2228

  Fly  1562 KERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQ---------T 1617
            ..||.|||||.|||.:|||:..||..|        :|.......:..||....|:         |
Mouse  2229 LHRVHMVQTECQYVYLHQCVRDVLRAK--------KLRNEQENPLFPIYENVNPEYHRALHVAVT 2285

  Fly  1618 KMGTLPIRA-SLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLA---TEVKPKGSN 1668
            ...|.|:.. :.|:...|:.::.:.:|.....|....:.:.|.   .:.|.|..|
Mouse  2286 PTITFPLPLHNCALPIVLNHNMQSTRDIKNSPEDPLDKSVSLCDFKKKQKQKNKN 2340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	21/101 (21%)
		fn3	247..328	CDD:278470	21/80 (26%)
		fn3	343..417	CDD:278470	19/77 (25%)
		fn3	443..525	CDD:278470	23/81 (28%)
		FN3	548..611	CDD:238020	16/66 (24%)
		FN3	620..706	CDD:238020	22/100 (22%)
		fn3	708..796	CDD:278470	17/89 (19%)
		fn3	824..886	CDD:278470	19/65 (29%)
		fn3	902..978	CDD:278470	23/77 (30%)
		fn3	1013..1092	CDD:278470	18/82 (22%)
		UP_III_II	1106..>1248	CDD:297589	52/165 (32%)
		PTPc	1329..1582	CDD:214550	144/260 (55%)
		PTPc	1355..1582	CDD:238006	129/234 (55%)
Ptprb	XP_036011586.1	Ricin_B_lectin	<22..93	CDD:395527
		Herpes_BLLF1	<158..>352	CDD:282904
		FN3	398..483	CDD:238020
		fn3	492..560	CDD:394996
		fn3	579..658	CDD:394996
		fn3	681..742	CDD:394996
		fn3	757..835	CDD:394996	17/97 (18%)
		fn3	844..917	CDD:394996	18/86 (21%)
		fn3	932..1010	CDD:394996	21/84 (25%)
		fn3	1020..1096	CDD:394996	20/87 (23%)
		fn3	1109..1182	CDD:394996	25/82 (30%)
		fn3	1196..1269	CDD:394996	15/78 (19%)
		fn3	1285..1365	CDD:394996	21/92 (23%)
		fn3	1375..1448	CDD:394996	14/82 (17%)
		fn3	1473..1536	CDD:394996	19/65 (29%)
		fn3	1550..1632	CDD:394996	24/93 (26%)
		fn3	1644..1723	CDD:394996	19/87 (22%)
		PTP_tm	1761..1931	CDD:408631	56/174 (32%)
		R-PTPc-B	2019..2246	CDD:350465	125/229 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1616
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1040
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm42906
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.710