DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and Y39A3A.4

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001370800.1	Gene:	Y39A3A.4 / 189720	WormBaseID:	WBGene00021435	Length:	265	Species:	Caenorhabditis elegans

Alignment Length:	265	Identity:	74/265 - (27%)
Similarity:	114/265 - (43%)	Gaps:	61/265 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1292 QDELAALP--EGYITPNRPVHVKDFSEHYRIMSADSDFRFS-EEFEELKHVGRDQACSFANLPCN 1353
            :|.|..|.  |.:|.....:.:....:.||.:.|..|...: :.:.:..|
Worm    28 EDHLQYLKALENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMH--------------- 77

  Fly  1354 RPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWE 1418
              |||:.:::..|:||.||: :|.....|||:|||:..:.....||.:||||..|..:||||.::
Worm    78 --KNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQ 139

  Fly  1419 SNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR------- 1476
            ..:.:|::|.:.   |||...:|||...|...||.|:|     |::.: |..||.:..
Worm   140 ERAESILLLCKV---GREGRPRYWPSLGVTETYGCIRV-----TNFSE-SSEEFEICNLAVTFVP 195

  Fly  1477 ----------NCESRIMRHFHFTTWPDFGVPEP-----PQSLVRFVRAFRDVIGTDMRPIIVHCS 1526
                      |.|...:....:..|||.|||:.     ||.|:..||         ..|.:||||
Worm   196 DNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVR---------HGPCVVHCS 251

  Fly  1527 AGVGR 1531
            ||..|
Worm   252 AGKDR 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020
		fn3	708..796	CDD:278470
		fn3	824..886	CDD:278470
		fn3	902..978	CDD:278470
		fn3	1013..1092	CDD:278470
		UP_III_II	1106..>1248	CDD:297589
		PTPc	1329..1582	CDD:214550	65/226 (29%)
		PTPc	1355..1582	CDD:238006	64/199 (32%)
Y39A3A.4	NP_001370800.1	PTPc	51..>256	CDD:214550	68/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910