DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and ptp-3

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_001263671.1 Gene:ptp-3 / 174685 WormBaseID:WBGene00004215 Length:2248 Species:Caenorhabditis elegans


Alignment Length:1873 Identity:423/1873 - (22%)
Similarity:685/1873 - (36%) Gaps:499/1873 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 LAQHANAADL---------VINVPNASSNANAFYRIDYSPPF----------------------- 97
            :.|||...|.         .:.|.: |..||.:.::...||:                       
 Worm   255 MIQHAREEDQGKYECIARNTLGVAH-SKAANLYVKVRRVPPYFSYKLERQYVVGVGGNINLTCVA 318

  Fly    98 -GFPEPNTTIPASD-----------IGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTA 150
             |:|.|......:|           |||::.....:..|| ||.....::....:.|.||.....
 Worm   319 VGYPMPRVFWKKTDLMVLDDPSTAPIGKNVLTLTHVESTE-NFTCVAVSALGNIEATTTVIAKEL 382

  Fly   151 PDPPANLSVQLRSSKSAFITWRPPGSGRYS--------GFRIRVLGLTDLPF------------- 194
            |.||.|:.|...:|:|..|||:||   :|:        .:|::.....|...             
 Worm   383 PPPPVNIVVSSVTSESVVITWKPP---KYNEAINKYVVNYRLKSENKDDAALFAKDSRAEDESDS 444

  Fly   195 ERSYSLEG----NETLQLSAKELTPGGSYQVQAYS--------VYQGKESVAYTSRNFTTKPNTP 247
            || || ||    .:|::.....|...|....|.|.        |..|.||:...::   |||:.|
 Worm   445 ER-YS-EGRSSRGKTMETLENSLVIDGLVAFQTYEFTVRSAGPVGVGLESLPVEAQ---TKPSKP 504

  Fly   248 GKFIVWFR----NETTLLVLWQP-PFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFK 307
            ....|..:    |..::||.|.| ..|.|:.|.|:|..|.|.....:...::.............
 Worm   505 ATAPVSPQARSLNRDSILVKWGPCEQPNGLITGYKVYYTNDLVTTPIREWKQHDAKSDEFMTTIN 569

  Fly   308 GLVPGREYNISV---QTVSEDETSSVPTTARYLTVP------------ERVLNVTFDEAYTTSS- 356
            ||.|...|.:.|   .:..:...|::.|.|....:|            .|.:.:|:|:...:|. 
 Worm   570 GLEPDSRYFVRVIAQNSEGDSPLSTLVTVATRQGIPGQPPMLTVKALDSRRMQLTWDKPLYSSPV 634

  Fly   357 -SFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYF----DYPDILEPGRTYEVVVKT 416
             .:.||      |:..|..:.:..||....:|....:.|..|:    .|.|..:...|..::.||
 Worm   635 VGYTVR------YNTSDGEKELTLTSPHEKHVVTGLHPDKYYYFRVAAYSDRGQGEFTEPMISKT 693

  Fly   417 IADNVNSWPA----------SGEVTLRPRPVRSLGGFLDDRSNALHISW---EPAETGRQDSYRI 468
            ||....|.|.          |.|:..:....:.|.|.|    .|..|::   |.::|...:|  :
 Worm   694 IASIPLSSPTIVSAAATSSKSVEIRWKGPEQKKLNGVL----TAYRINYFRLEDSKTANLES--V 752

  Fly   469 SYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQA---------LSKGVASNA 524
            .|.|..:.|   :.|.......:.::.|.|.|..||....|.|.|.|         .|..|....
 Worm   753 EYDEDMDDS---SSFLDRMSVVVPSDATSYVLSDLLPYSSYEITVAASTMDGYGPESSIRVVKTL 814

  Fly   525 SDITRYTRPAAP--LIQELRSIDQGLMLSWRSD--VNSRQDRYEVHYQR--NGT------REERT 577
            .|:     |:||  ...||.|. ..:.|:|.:.  .|.....|.|:..|  ||.      .::|.
 Worm   815 EDV-----PSAPRNFNAELTSA-TSVKLTWDAPAAANGALLGYYVYLDRMVNGEPVVEKGSKKRI 873

  Fly   578 MATNETS---LTIHYLHPGSGYEVKVHAISH---GVRSEPHSYF-QAVFPKPPQ--NLTLQTVHT 633
            :...::|   ..:..|.|.:.|..:::|.:.   |..||..|.. |.:.|:.|:  :::|.....
 Worm   874 VMIRDSSKRYFELDSLDPNTEYSFRLNAFNRNGDGEFSERKSIITQGIPPEAPEIVSVSLDRDEP 938

  Fly   634 NLVV-LHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGV-- 695
            .:|. :.|:.|:.......:.:|..    |.|..|..::..:.|.:. |......::.:..||  
 Worm   939 PVVARIEWKMPKMKPNETPIEKYNL----WLRAQGYPDSYVKAKTVD-GTDLSTTISGLWMGVVY 998

  Fly   696 ------ESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDR---- 750
                  |:......|.|   :.::..|...|...:.:::....|.:   .:.|.|..||.|    
 Worm   999 DVLLAAENREGRSQNAT---ETIATPVGSPDGEPIDVQYEVMKGKI---VVSWRPPSEEKRNGNI 1057

  Fly   751 VEFKNVTQLEDLSSPSVRIPIE--------DLSPGRQYRFEVQASS------------------- 788
            ..:|.:....|.::.....|:.        :::..|.|.|:|.|::                   
 Worm  1058 TSYKAILSAMDATADRYEQPVPAPSTSSTFEVNVRRAYLFKVAAATMKGIGPYSPVLTINPDPAA 1122

  Fly   789 -----NGIRSGTTHLSTRTMPLIQ-------SDVFIANAGHEQGQDETITLSYTPTPADSTRFDI 841
                 ..:|...|..||   .::|       :|.|:....||.|                .|.|.
 Worm  1123 LVGPPTNVRVEATSNST---AVVQWDFESQKADSFVVKYMHEPG----------------NRMDT 1168

  Fly   842 YRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSG---GVASLPVQRLYRLHP-LP 902
            .::........|||    :.:|....|.|...|.|...|..|..   |..|.|...|..:.| ..
 Worm  1169 EKWKQLPVVSIDKE----NPKRFAVVSDLNAHKPYAFCVLAVKNNRQGPCSDPPTVLESVTPTYM 1229

  Fly   903 ISDLKAIQVAAREITLHW--TAPAG-----------EYTDFELQYLSADEEAPQLLQNV-TKNTE 953
            :.:|:.:...:..:.|.|  ..|..           :|.:.|||  ......|...|:| .|:.|
 Worm  1230 VQNLRVLWKTSNSVQLTWEYNGPRNVGFYVNHTGRKDYVNHELQ--EKTMSTPGFGQDVDEKHRE 1292

  Fly   954 ITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDV 1018
            .....|||:..||..|.||:.......:....|.|:...:.|      .....|..||   .|..
 Worm  1293 YLWTNLRPHMMYTIHVGVRTLPPGARKYWPQEVVTITDPTGP------PFVDVPKLVD---SSGT 1348

  Fly  1019 QPGEVTFEWSLEPA-EQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQ 1082
            |||:....  |.|| |::|||.::.|.                          |||.|:      
 Worm  1349 QPGQQMIR--LTPATEEYGPISHYWII--------------------------LVPANY------ 1379

  Fly  1083 AKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIA 1147
                          .|..::       ::.|:|:.:.::           .....:.||.::..:
 Worm  1380 --------------STEDVV-------NLDPIELEKATA-----------EKRAQLARSLSVSPS 1412

  Fly  1148 EDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIG-TANCDKHQ- 1210
            :.:.:.||.:    ..|.|:.:          |:|  ....:|::::...:.|.. :|:..|.| 
 Worm  1413 KKLKRKASEV----GDDSQSAS----------YHP--KEKRARRATVPGAYVTARLSADRVKQQY 1461

  Fly  1211 --------------AGYCNGPLRAGTTYRIKIRAFTDED-------------------KFTDTVY 1242
                          .|:.|.||.....||:.:|||...|                   .::|:|.
 Worm  1462 RNNQPFIVGDSQLYDGFTNYPLEHNLHYRLMMRAFAKNDVRTKDSFEQRAPMSEKLSRMYSDSVL 1526

  Fly  1243 SSPIT-------TERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQ-------------------- 1280
            :.|.|       ..:..:..|.|.::.::|.::|.:::....||.                    
 Worm  1527 TEPFTIKSALRGASQKSSPWVGACIAFLVLFSIVGMLICWWLRCNKKSAGRHPRHGSITKVALTG 1591

  Fly  1281 --------LIRRASKLARMQDE-----------------------LAALP------EGY-----I 1303
                    :....|||....:|                       |..||      .||     .
 Worm  1592 NIMNGGGGIPGETSKLLSTSNEYGRQIMNPYEQMNGNHHMESSMDLYPLPTSHSRSNGYAPVPVA 1656

  Fly  1304 TPNRP-------------VHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRP 1355
            .|:.|             |.:.:.:.|...:..:::..|..|||.:: .|:......::...|:.
 Worm  1657 IPSLPNNGNNMTTVSHPAVPIAELANHIERLRMNNNAGFQSEFESIE-TGQHFTWEHSSADMNKH 1720

  Fly  1356 KNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESN 1420
            |||:.|:..|||||..|..|:...|.|||||||:.|::.||.:|.|||||..|..:||||.||..
 Worm  1721 KNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQ 1785

  Fly  1421 SRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEF---MVSRNCESRI 1482
            |..|||||...|:.|.||||||| .|....||||:|.|:...|...:::...   ||... |.|.
 Worm  1786 SVTIVMLTNLEERSRVKCDQYWP-SRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEP-EVRE 1848

  Fly  1483 MRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK 1547
            ::|..:|.|||.|||:.|...:.|::..:.:...|..|||.|||||:||:|.||.:|.:|:.:..
 Worm  1849 IKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRY 1913

  Fly  1548 SDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELH 1599
            .:.|||:|.|.|:|.:|.:|||||:||:.||..:| ||..|...:.|..|..|
 Worm  1914 DNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH 1966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 30/123 (24%)
fn3 247..328 CDD:278470 19/88 (22%)
fn3 343..417 CDD:278470 16/79 (20%)
fn3 443..525 CDD:278470 21/93 (23%)
FN3 548..611 CDD:238020 16/78 (21%)
FN3 620..706 CDD:238020 16/96 (17%)
fn3 708..796 CDD:278470 17/123 (14%)
fn3 824..886 CDD:278470 12/64 (19%)
fn3 902..978 CDD:278470 21/89 (24%)
fn3 1013..1092 CDD:278470 16/79 (20%)
UP_III_II 1106..>1248 CDD:297589 29/183 (16%)
PTPc 1329..1582 CDD:214550 111/255 (44%)
PTPc 1355..1582 CDD:238006 105/229 (46%)
ptp-3NP_001263671.1 I-set 93..184 CDD:254352
Ig 106..185 CDD:299845
IG_like 201..287 CDD:214653 8/32 (25%)
Ig 212..288 CDD:299845 8/33 (24%)
IG_like 302..378 CDD:214653 13/76 (17%)
Ig 309..377 CDD:299845 12/68 (18%)
FN3 383..499 CDD:238020 30/123 (24%)
FN3 507..600 CDD:238020 20/92 (22%)
FN3 605..693 CDD:238020 17/93 (18%)
FN3 700..813 CDD:238020 27/121 (22%)
FN3 818..918 CDD:238020 24/100 (24%)
FN3 923..1020 CDD:238020 17/104 (16%)
FN3 1027..1116 CDD:238020 14/91 (15%)
fn3 1125..1213 CDD:278470 22/110 (20%)
PTPc 1694..1949 CDD:214550 111/257 (43%)
PTPc 1720..1949 CDD:238006 105/230 (46%)
PTPc 1980..2239 CDD:214550
PTPc 2008..2239 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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