DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and dep-1

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001254192.1	Gene:	dep-1 / 174437	WormBaseID:	WBGene00009717	Length:	1367	Species:	Caenorhabditis elegans

Alignment Length:	1356	Identity:	372/1356 - (27%)
Similarity:	574/1356 - (42%)	Gaps:	285/1356 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 VPAPFPV----AAESQ-ITTNLTEYTLDS------------------LLAGRRYLIAVQALSKGV 520
            :|...|:    ||:.| :|.|:::...||                  |.||.||.||:.....|.
Worm    55 LPRRHPLYQSFAAKIQDVTENISDEVRDSNKTFVSSDDAPYSIRIHALRAGHRYSIAIHGQKDGS 119

  Fly   521 ASNASDITRYTRPAAPLIQELRSIDQGLM-----LSWRSDVNSR--QDRYEVHY-QRNGTREERT 577
            .|...:.:....|.||   :.||:|..:.     ::.|:..|..  ||.:.:.| |.|..::...
Worm   120 TSLIKEESVVMDPRAP---DFRSMDSDIQVAEHNITMRTIKNDSYLQDSFSIEYRQINPDKKFPV 181

  Fly   578 M----ATNETSLTIHYLHPGSGYEVKVHAISH--GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLV 636
            :    ...:.:|..:..:..||::..|..|:|  |:.|.|........|.|.:.:.:.....:.|
Worm   182 LQILDIPEQKNLEFYLGNLNSGFDYSVRVIAHKDGMSSRPWISTLTTKPSPLKEVNINQNAGSCV 246

  Fly   637 VLHWQAPE--GSDFSEYVVRYRTDASPWQRIS-GLHENEARIK---DMHYGERYLVQVNTVSFGV 695
            .:.||..|  |:||  |.::|...::|....: .:...|:.|.   .|..||.|.: :.||..|.
Worm   247 EVSWQNDEFSGADF--YTIQYSLQSTPNNSTNMTIPSTESSISICDSMLQGEAYQI-IATVQKGG 308

  Fly   696 ESPHPLELNVTMPPQPVSNVVPLVDSR----------NLTLEWPRPDGHVDFYTLKWWPTDEEDR 750
            :...||.....:.|      :|.:|.|          .|..|.| ....:|...:.....:.|..
Worm   309 QVSEPLITKFQLRP------LPPIDFRVRADLKRGKYKLLAELP-TSSKIDKCQITVAGDEAERS 366

  Fly   751 VEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANA 815
            |.:.|:.|.:  |...:......||||.::.|.:.:.:|...|.....|....|....:.|....
Worm   367 VNYANIEQTK--SGHKICWFNFALSPGERFDFSISSMANESASQKLQKSIVLTPAFDFNAFGLTL 429

  Fly   816 GHEQGQDETITLSYTPTPADSTRF-DIYRFSMGDPTIKDKEKLAN----------DTERKLSF-- 867
            ....|   .|.|.:..:....||. ||:...:|      .|.|.|          :|::.|.|
Worm   430 QESNG---GIELIWPKSEVFMTRVKDIWNKVVG------AESLLNMRITPIGNNDETDKTLKFET 485

  Fly   868 ----------SGLTPGKLYNVTVWTV--SGGVASLPVQRLYRLHPLPISDLKAIQVAAREIT--- 917
                      ..|..|..|.|.::||  :|.::........|:      ...|:.|:...:|
Worm   486 SPKNIDPVFAKNLVKGACYRVQLFTVTKTGIISETRHNETIRM------SSPAVNVSLESVTRSS 544

  Fly   918 --------LHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEIT--------LQGLRPYHNYT 966
                    .|..:.:  .::.::..:..|.....:..   |..::|        |.||.|:|.||
Worm   545 ATLRIVFSTHHDSTS--ISNCQMHIVVRDMNGKSVFD---KRMQLTATFAPLLNLDGLSPFHKYT 604

  Fly   967 FT--VVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSL 1029
            ..  ::..|||.: |.....:..|:.:      .|:.|....|..|...:...:....|...| |
Worm   605 VNTQIICGSGSSE-TPQCPAATRTMRQ------LSFSTRQDKPAAVQDLKVEPLNSYSVMLTW-L 661

  Fly  1030 EPAEQHGPIDYF--RITCQNADDAADVS---SYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGY 1089
            .||..:|.:.::  .:|...:|:...:.   |.....:..|..||.|..|:.|.|.::|.:..|:
Worm   662 PPALPNGILTHYAVNVTKIGSDETRTIDVGVSSNRSDHTVQVVIDELFGGHTYSFSVRAVTEAGF 726

  Fly  1090 GAEREHIQT--MPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGK 1152
            |.....:.|  ||::|||||..:...::.|..|..:.:.|....|.|.:|.::.:.||::|....
Worm   727 GENSPVVPTVSMPLMAPPVPTVAPMIMKESVGSHNMIVRFPTTMFDNRNGEIKQFAIIVSETTAD 791

  Fly  1153 NASGLEMPS------WQDVQAYTVWLPY----QAIEPYN-----PFLTSNGSRKSSLEAEHFTIG 1202
            .:....:.|      ||.||.:.||..|    |.|:...     ......|..::.||.....|
Worm   792 ESINRWIESDNGTYTWQQVQRFDVWPSYVAKLQDIQKVKQDVDVSIFEELGEDETCLEVRADRI- 855

  Fly  1203 TANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLV- 1266
                       ||||||:.:.||::||.||....|||:..|..:||..:...|...||.|||:|
Worm   856 -----------CNGPLRSASKYRVRIRLFTSPTLFTDSPPSQVMTTGSATPAIPLLTVVAVLIVI 909

  Fly  1267 AMVLVV----VYCQHRCQLIRRAS----------------KLARMQDELAA-------------- 1297
            |.|.:|    ::..:|.:..|.|:                .|..|..|.||
Worm   910 AFVGIVGTIFLFFWNRTKKARLAAAAFKNGPSKEKESQWEALKMMMAERAADCLAKLGLDATTPP 974

  Fly  1298 ----------------------------------------------------LPEGYI--TP--- 1305
                                                                |..|.:  ||
Worm   975 PSSTTSSNSPTSTSTTMTDCGSNPHLGAPNAGGHRRTRSLRERTGVEHRLERLSSGPVHRTPLYT 1039

  Fly  1306 ---------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTN 1361
                     :|||.::||::|.|:||||||||||||::.:::||..|:.:.:.||.|||||||||
Worm  1040 VVTGANTNKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTN 1104

  Fly  1362 ILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVM 1426
            |..|||||.||...::.:|.|||||||:||.:|.||||..||||.:||:.||:|.||....||:.
Worm  1105 IPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIA 1169

  Fly  1427 LTRCFEKGREKCDQYWP-VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE----SRIMRHF 1486
            ||:|.||||:||.|||| .:.|.:.||||:|.::.:..:.::.|.:..:.::..    :|.:||:
Worm  1170 LTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHW 1234

  Fly  1487 HFTTWPDFGVPEPPQSLVRFVRAFRDVI--GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSD 1549
            |:..|||||.|..|..:::|.|.||..:  .....|.|||||||||||||||::||:||.....|
Worm  1235 HYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGD 1299

  Fly  1550 YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE-HLLADSLELHANDGY 1604
            .:|:||.|..||.||..|||.||||:.||.|:|.||:|.. ...:.|...|.|.|:
Worm  1300 PIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGSSPSPTSTSTGAHHNAGF 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470	18/68 (26%)
		FN3	548..611	CDD:238020	15/76 (20%)
		FN3	620..706	CDD:238020	23/91 (25%)
		fn3	708..796	CDD:278470	20/97 (21%)
		fn3	824..886	CDD:278470	19/86 (22%)
		fn3	902..978	CDD:278470	17/96 (18%)
		fn3	1013..1092	CDD:278470	19/83 (23%)
		UP_III_II	1106..>1248	CDD:297589	41/156 (26%)
		PTPc	1329..1582	CDD:214550	128/259 (49%)
		PTPc	1355..1582	CDD:238006	117/233 (50%)
dep-1	NP_001254192.1	FN3	640..736	CDD:238020	21/96 (22%)
		PTPc	1072..1333	CDD:214550	128/260 (49%)
		PTPc	1098..1333	CDD:238006	117/234 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158858
Domainoid	1	1.000	265	1.000	Domainoid score	I1007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70980
Inparanoid	1	1.050	451	1.000	Inparanoid score	I899
Isobase	1	0.950	-	0	Normalized mean entropy	S5167
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm14294
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880