Protein Alignment Ptp4E and C18E9.7

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001348641.1
• Gene: C18E9.7 / 174432
• WormBaseID: WBGene00007687
• Length: 893
• Species: Caenorhabditis elegans
• Alignment Length: 1257
• Identity: 244/1257 - (19%)
• Similarity: 404/1257 - (32%)
• Gaps: 509/1257 - (40%)

  Fly    54 VWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEP-------------NTT 105
            ::|::.:|..:.:..::::.||....:|.......|.|:||||.|:|..             |.|
 Worm     1 MFLLIFLLASYNSIASSSSILVDFTSHAIQPTPQAYIIEYSPPVGYPPSGSAVEGTTFYSLINGT 65

  Fly   106 IPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFIT 170
            |.|:|....|. :..:.||..|.          .:||    :.::||.|...|:: .:...|.|:
 Worm    66 ISATDYTVSIS-AILMDGTRQNI----------GELT----VFSSPDAPTLDSIE-TTEHEATIS 114

  Fly   171 WRPPGSGRYSGFRIRVLGLTDLPFERSYSLE---------GNETLQLSAKELTPGGSYQVQAYSV 226
            :.|| .|:            ::.:...|..|         ..:|..:..:.|..|.:::::..||
 Worm   115 YFPP-QGQ------------NITYHMEYYPEEHKEYTNPIDTKTALVKLRGLDSGTTFRLRIRSV 166

  Fly   227 YQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLY 291
            |||..|..:....|||:..                            .:|..|.:.:
 Worm   167 YQGVLSQEFIDTTFTTQGT----------------------------ANYDYSSSAE-------- 195

  Fly   292 VEREGEPPGPAQAAFKGLVPGREYNISVQT------------VSEDETSSVPTTA--RYLTVPER 342
                       |.:.|.|.|  .:||.:||            |.||.|.:.|..|  ...|.|.|
 Worm   196 -----------QYSVKTLPP--NFNIGLQTTTEMTSYEYSREVEEDPTITTPLVAVTTTFTPPVR 247

  Fly   343 ---VLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVML----STSRR-IFNVPRAA-----NGD 394
               :::.|..|:.|||:.      |..|.:|....:|.|    :|.|| ....|:|:     :||
 Worm   248 ETVMVSTTTAESSTTSTI------PEVTETEVSTTEVTLQKETTTPRRPTTTKPKASPMEVNSGD 306

  Fly   395 ----------SVYFDYPDIL-EPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRS 448
                      :|..|.|::: |.|...|:           |                   |.|.:
 Worm   307 LGEDHPSENTNVLVDLPEMIKEYGEPSEI-----------W-------------------LSDEN 341

  Fly   449 NALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNL---TEYTLDSLLAGRRYL 510
            ..|.:.||..|....:::.::|...|.:.  |..|.:|...: ..|:   .|:|||.    |.:.
 Worm   342 EMLRLDWEAPENANCEAFFVNYTILTLSR--PRSFSLATSDE-NANIKMFPEHTLDI----RVFC 399

  Fly   511 IAVQALSKGVASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREE 575
            :...||||                                :|..
 Worm   400 MIAGALSK--------------------------------TWWG--------------------- 411

  Fly   576 RTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTN-----L 635
                                     |.|:|..:           ||..:|:.:..|:|:     .
 Worm   412 -------------------------HRIAHLSK-----------PKQLENVRVTEVNTDEFYVAS 440

  Fly   636 VVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHP 700
            :.|.|..|...||..|.:                                    .:|||:.....
 Worm   441 IKLAWDWPVYHDFKSYKI------------------------------------VISFGIGRAES 469

  Fly   701 LELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSP 765
            .|:.||                                          ::.||
 Worm   470 KEMEVT------------------------------------------NKEEF------------ 480

  Fly   766 SVRIPIEDLSPGRQYRFEVQASSN--GIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQ--DETIT 826
               :.::.|.|...|...::.:|.  .:.|.||.|...|.|:|.|.|:       .||  ..:|.
 Worm   481 ---VLLDKLDPSNSYSISIRNASTELSLTSKTTQLEQVTAPIISSTVY-------PGQISSNSIN 535

  Fly   827 LSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLP 891
            :::..:..:..|||.|..:.........:|:..:.|:..:|:.|.|||.|..:|:||..||.|.|
 Worm   536 INFGDSDPEQGRFDYYLLTFSGNNKNISKKVEMEHEKSFTFTKLIPGKTYQFSVYTVYKGVRSRP 600

  Fly   892 VQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITL 956
            |......:||.::.|..: |....:.|:|        |.|
 Worm   601 VTADITTYPLKVNQLFPV-VGKDYVVLYW--------DIE------------------------- 631

  Fly   957 QGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPG 1021
                                   :|||                                ||.:
 Worm   632 -----------------------NFAD--------------------------------SDCR-- 639

  Fly  1022 EVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSA 1086
                               ||:: .|||:...| |.|.. .|::.:...|....:|.|.|.....
 Worm   640 -------------------FRLS-YNADNIPTV-SVELK-GASRHRFSALKAEVYYTFTITVIMG 682

  Fly  1087 LGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQ--GYFSNAHGMVRSYTIIIAED 1149
            ||..|.....:.:.:   .:|:..::|....:.|..:.:.|..  ..||..:|...::.:|:::|
 Worm   683 LGQAAAESESEMITV---AIPKGRLSPSIHRQGSRELVVGFDNDLSVFSLLNGSPDNFAVIVSDD 744

  Fly  1150 VGKNASGLEMPSWQDVQAYTVWLPYQAI-EPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAG- 1212
            ...|....|:.||.:|:...||..|:|. ..:||| .|...|:::     ||:||.:|.|....
 Worm   745 TDLNDDNYELKSWFEVKDEEVWGSYRASPSTWNPF-DSERVRRAA-----FTVGTDDCVKRNLDE 803

  Fly  1213 -YCNGPLRAGTTYRIKIRAFTD 1233
             ||||.|||||.||:|||.:||
 Worm   804 PYCNGILRAGTDYRVKIRMYTD 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	54/273 (20%)
		fn3	247..328	CDD:394996	13/92 (14%)
		FN3	319..>749	CDD:442628	77/475 (16%)
		fn3	708..796	CDD:394996	7/89 (8%)
		fn3	902..978	CDD:394996	6/75 (8%)
		fn3	1013..1092	CDD:394996	17/78 (22%)
		PTP_tm	1127..1247	CDD:465889	42/112 (38%)
		R3-PTPc	1358..1579	CDD:350396
C18E9.7	NP_001348641.1	FN3	96..182	CDD:238020	21/99 (21%)
		FN3	424..497	CDD:214495	20/165 (12%)
		FN3	529..607	CDD:238020	21/77 (27%)
		PTP_tm	725..841	CDD:465889	41/107 (38%)