DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp4E and egg-5

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_491316.1	Gene:	egg-5 / 172007	WormBaseID:	WBGene00020035	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	75/305 - (24%)
Similarity:	129/305 - (42%)	Gaps:	43/305 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1353 NRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCW 1417
            |:.|.|...:...|.:|..||........|:|:||.:.|.....|||:||.|:.:|.::||||.|
Worm   432 NQEKCRNPRVHCRDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVW 496

  Fly  1418 ESNSRAIVMLTRCFEKGREKCDQYW---PVDRVAMFYGDIKVQ----------LIIDTHYHDWSI 1469
            :.....|||||.  .|..|:|:.||   |.|......|.::::          |...||..
Worm   497 QEEVPYIVMLTS--RKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLR---- 555

  Fly  1470 SEFMVSRNCESRIMRHFHFTTWP-DFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSG 1533
               ::..:.|.|.:.|     |. |........|.:..:|..|:.    .:|:::|...||.|:.
Worm   556 ---LIGPDREERHVEH-----WQGDVNNSSNMYSPLNILRLLRNA----SKPVVIHDHLGVSRAA 608

  Fly  1534 TFIALD-RILQHIHKSDY-VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSL 1596
            ..:|.: .|...:....| ..:...|..:|:.|.|.::|..||:.:|:.:....   ..::..:.
Worm   609 CLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF---RDVIGSAK 670

  Fly  1597 ELHANDGYEVTKIYLERQPQTKMGTL--PIRASLAMAEKLDADLM 1639
            ||..:  ||  :...||..:..:..|  ||.....::.:.|.|::
Worm   671 ELDVD--YE--RWLQERSERMFLDDLAAPIPGYRLLSPRADPDIV 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020
		fn3	708..796	CDD:278470
		fn3	824..886	CDD:278470
		fn3	902..978	CDD:278470
		fn3	1013..1092	CDD:278470
		UP_III_II	1106..>1248	CDD:297589
		PTPc	1329..1582	CDD:214550	64/244 (26%)
		PTPc	1355..1582	CDD:238006	63/242 (26%)
egg-5	NP_491316.1	PTPc	407..660	CDD:214550	64/245 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910