DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and Ptprh

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001178874.1	Gene:	Ptprh / 171125	RGDID:	620553	Length:	971	Species:	Rattus norvegicus

Alignment Length:	1050	Identity:	292/1050 - (27%)
Similarity:	446/1050 - (42%)	Gaps:	187/1050 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 TNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPE 644
            |..|.:|:..|.|.|.||..|.|...||...|.:......|.|.:||.::..:|..:.|.|..||
  Rat    27 TAGTRVTVDRLAPASSYEFSVWAEKDGVSGSPQTLIATTAPNPVRNLRVEGQNTTSISLSWDPPE 91

  Fly   645 GSDFSEYVVRYRTDASPWQ---RISGLHENEAR--------IKDMHYGERYLVQVNTVSFGVESP 698
            .|.        ..|.:.|.   |..|  :||.|        :..:..|..|...|.....||.|.
  Rat    92 NSS--------SQDLTYWAQCIRYDG--QNETRHTKDTRVTVDGLDPGTSYECSVRVEKDGVYST 146

  Fly   699 HPLELNVTMPPQPVSNVVPLVDSRNLT---LEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLE 760
            ...: |.|..|.||.|:  .|:.:|.|   |.|..|: :.....|.:|.  :..|.:.:|.|:
  Rat   147 WETK-NTTTAPNPVRNL--RVEGQNTTSISLSWDPPE-NSSSQDLTYWA--QCIRYDGQNETR-- 203

  Fly   761 DLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDET- 824
              .:...|:.::.|.||..|...|:...:|:.|.....:|.|.|....::.:      :||:.|
  Rat   204 --HTKDTRVSVDGLDPGTSYECSVRVEKDGVYSTWETKNTTTAPNPVRNLRV------EGQNTTA 260

  Fly   825 ITLSYTPTPADSTRFDIYRFSM-----GDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVS 884
            |:||:.| |.:|:..|:..::.     |    |::.:...||  :::..||.||..|..:|....
  Rat   261 ISLSWDP-PENSSSQDLTYWAQCIGYDG----KNETRHTKDT--RVTVDGLDPGTSYECSVRVEK 318

  Fly   885 GGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNV- 948
            .||.|....:.....|.|:.:|:........|:|.|..|..          |:.::.....|.:
  Rat   319 DGVYSTWETKNTTTAPNPVRNLRVEGQNTTAISLSWDPPEN----------SSSQDLTYWAQCIG 373

  Fly   949 ---------TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLT 1004
                     ||:|.:|:.||.|..:|..:|.|....:..|      ..|...::.||||
  Rat   374 YDGKNETRHTKDTRVTVDGLDPGTSYECSVRVEKDGVYST------WETKNTTTVPISA------ 426

  Fly  1005 APPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDY-FRITCQNADDAADVSSYEFPVNATQGKI 1068
              |..|...:........::..|  :|.|.....|. :...|...|...:...    ...|:..:
  Rat   427 --PNPVRNLRVEGQNTTSISLSW--DPPENSSSQDLTYWAQCIRYDGQNETRH----TKDTRVSV 483

  Fly  1069 DGLVPGNHYIFRIQAKSALGYGA-EREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGY- 1131
            |||.||..|...::.:....|.. |.::..|:             |..|:.||.   ||...||
  Rat   484 DGLDPGTSYECSVRVEKDGVYSTWETKNTTTV-------------PAAVNITSC---ISTSGGYG 532

  Fly  1132 ----FSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKS 1192
                :|...|...::.:    :||:        .|.                     :.|||.
  Rat   533 IILTWSCPSGSYETFEV----EVGR--------KWS---------------------SQNGSL-- 562

  Fly  1193 SLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVA 1257
                         |.|   |.....|....:|...:...::..|    |.|:|.|.....|.::|
  Rat   563 -------------CGK---GMTVLDLEPAQSYTATVTTVSNSLK----VQSAPATCRTESTAVIA 607

  Fly  1258 ATVSAVLLVAMV--LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRI 1320
            ..:..:||:.::  |::|:.:.|    |:..:...:..:|.....|.|.      .|||::|.|.
  Rat   608 GAIVGILLLFILVGLLIVFLKRR----RKKQQPKEVPKDLVFRFPGDIL------AKDFADHVRE 662

  Fly  1321 MSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYIN 1385
            ...||:..|:||:::|...|:.|:...|....|..|||:.|:||||.||..|||:.::.||||||
  Rat   663 NEKDSNCGFAEEYQQLALEGQGQSQMTALALENVSKNRYRNVLPYDWSRVPLQPLHEEPGSDYIN 727

  Fly  1386 ANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF 1450
            |::|||..||:|||.|||||..|..:||||.||..|..:|||..|.|.|:.||:.|||:|.....
  Rat   728 ASFMPGLWSPKEFIATQGPLPHTVSDFWRMVWEQQSHTLVMLANCMESGQVKCEHYWPLDAQPCT 792

  Fly  1451 YGDIKVQLIIDTHYHDWSISEFMVSRNCESRIM--RHFHFTTWPDFGVPEPPQSLVRFVRAFRDV 1513
            :|.::|.|:.:....:|::....:....|.:.:  |.||:..|||.|||..|..|:.|.:..|..
  Rat   793 HGQLQVTLVSEEVTENWTVRHLQLFHMKEQQTLSVRQFHYVAWPDHGVPYSPDPLLAFQKLLRQW 857

  Fly  1514 IGTDM--RPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVC 1576
            :...|  .|.||||||||||:||.||||.:|:.:.....||.|..|..||:.|..|||||.|||.
  Rat   858 LDQTMDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVDPFSFVKKMRESRPLMVQTEAQYVF 922

  Fly  1577 IHQCLLAVLE 1586
            :|||:|..|:
  Rat   923 LHQCILRSLQ 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020	12/30 (40%)
		FN3	620..706	CDD:238020	24/96 (25%)
		fn3	708..796	CDD:278470	23/90 (26%)
		fn3	824..886	CDD:278470	18/67 (27%)
		fn3	902..978	CDD:278470	18/85 (21%)
		fn3	1013..1092	CDD:278470	14/80 (18%)
		UP_III_II	1106..>1248	CDD:297589	25/146 (17%)
		PTPc	1329..1582	CDD:214550	116/256 (45%)
		PTPc	1355..1582	CDD:238006	108/230 (47%)
Ptprh	NP_001178874.1	FN3	67..154	CDD:238020	24/97 (25%)
		FN3	156..243	CDD:238020	24/95 (25%)
		FN3	245..332	CDD:238020	24/99 (24%)
		FN3	334..421	CDD:238020	21/102 (21%)
		FN3	427..514	CDD:238020	17/92 (18%)
		PTPc	670..929	CDD:214550	116/258 (45%)
		PTPc	698..928	CDD:238006	108/229 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020