DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and ptprfa

DIOPT Version :10

Sequence 1:NP_525076.2 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:XP_068077727.1 Gene:ptprfa / 140819 ZFINID:ZDB-GENE-020107-2 Length:1910 Species:Danio rerio


Alignment Length:1731 Identity:424/1731 - (24%)
Similarity:655/1731 - (37%) Gaps:430/1731 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 PFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTA----PDPPAN 156
            |.|||    ||   |:|..:|.                     .:.|.|..:..|    |||..:
Zfish   131 PHGFP----TI---DMGPQLKV---------------------VERTRTATMLCAASGNPDPEIS 167

  Fly   157 -----LSVQLRSSKSAFITWRPPGS----------------GRYSGFRIRVLGLTDLPFERSYSL 200
                 |.|.:.||.......|..|:                |:|....:...|       ..||.
Zfish   168 WFKDFLPVDINSSNGRIKQLRSGGTPIRGALQIENSEESDQGKYECVAVNSAG-------TRYSA 225

  Fly   201 EGNETLQL-----------SAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWF 254
            ..|..:::           :..|:.||||..:...:|                  ..|..::.|.
Zfish   226 PANLYVRVRRVPPRFSIPPTNHEVMPGGSVNLTCVAV------------------GAPMPYVKWM 272

  Fly   255 RNETTLLVLWQPPFPAGI--YTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNI 317
            :.|..|....:.|....:  .|:.|.|                                |....:
Zfish   273 KGEQELTKEEEMPIGRNVLELTNIRQS--------------------------------GNYTCV 305

  Fly   318 SVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEP--PRTYSEFDAYQVMLST 380
            ::.::...:|:: ..|.:.|..|...|.||    .||::|..:.|:.  |...|    |.|:...
Zfish   306 AISSLGMIDTTA-QITVKALPRPPASLIVT----ETTATSVTLTWDSGNPEPVS----YYVIQYR 361

  Fly   381 SRRIFNVPRAANG----DSVYFDYPDI--LEPGRTYEVVVKTIADNVNSWPASGEVTLRPR---- 435
            |:      .:.||    |.|......|  |.|...||..|..: :|:...|.||.|..|..    
Zfish   362 SK------ISDNGFQEVDGVASTRYSIGGLSPYSEYEFRVMAV-NNIGRGPPSGMVETRTSEQAP 419

  Fly   436 ---PVRSLGGFLDDRSNALHISWEPAE--TGRQDSYRISYHEQTNASEVPAPFPVAAESQITT-- 493
               |:|.....|.  :..:.:.|||.|  .|:...||:.|....:       ||::...:..|  
Zfish   420 SSPPLRVQARMLS--ATTMLVQWEPPEEPNGQIRGYRVYYTSDLH-------FPLSTWQKHNTED 475

  Fly   494 -NLTEYTLDSLLAGRRYLIAVQALSKGVASNASDI----TRYTRPAAPLIQELRS-IDQGLMLSW 552
             :||  |:..|:....|.:.|.|.:.......|||    |:...||.|...|..: :|..:||||
Zfish   476 SSLT--TISGLVPDITYGLRVLAFTSVGDGPPSDILQVKTQQGVPAQPTGFEAEAELDTRIMLSW 538

  Fly   553 RSDVNSRQDRYEVHY-QRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISH---GVRSEP-- 611
            ...|..:..:||:.| :.:...:...:.....|..|..|.|.:.|:..:.|.|.   ||.::|  
Zfish   539 LWPVQDQITKYELTYWEADSDNKHHVIFDPAGSYAIDSLKPDTLYKFSLAARSEMGLGVYTQPIE 603

  Fly   612 HSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIK 676
            ....|:....|||.:.|.::.::.:.:.|.||..:.....:|||   :..:|.:||..:....:|
Zfish   604 ARTAQSAPSAPPQEVHLISLSSSSIKVSWVAPPAASRHGSIVRY---SLAYQAVSGEDQERHEVK 665

  Fly   677 D------------MHYGERYLVQVNT---VSFGVESPHP-LELNVTMPPQPVSNV-VPLVDSRNL 724
            |            :.....|.|.|..   |..|.||... :.....:|..|...| |..::|..|
Zfish   666 DIPADVSSYVLEGLEKWTEYTVWVKAHTDVGPGPESGSTRIRTQEDVPGAPPRRVEVDNINSTAL 730

  Fly   725 TLEWPRP-----DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSP---SVRIP------IEDLS 775
            .:.|..|     .||:..|           :|.:..:...|....|   .|.:|      |..|.
Zfish   731 RVSWKPPLQQKQHGHIRGY-----------QVVYSRLENGEPRGQPIILDVALPEAQEAVISGLL 784

  Fly   776 PGRQYRFEVQA---SSNGIRSGTTHLSTR-TMPLIQSDVFIANAGHEQGQDETITLSYTPTPADS 836
            |...|...|.|   ..:|.||....::|. .:|...:.:.....|:      |..:.:.| |.:.
Zfish   785 PETTYSVTVAAYTTKGDGARSKAKVVTTTGAVPGKPTMIISTTIGN------TALIQWQP-PKEM 842

  Fly   837 T--------RF-----DIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPG-----KL-------- 875
            .        |:     |||       |::|..:    |:...:.:||..|     ||        
Zfish   843 VGELMGYRLRYKREEEDIY-------TVRDFRR----TDDHFTVTGLHKGATYIFKLCAKNRAGN 896

  Fly   876 ---YNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPA-----GEYTDFEL 932
               |:..:.|.....:|.|            .:||.:.:......|.|..|.     |:...:.:
Zfish   897 GEEYSKEISTPEDVPSSYP------------QNLKVVGLTTTTTKLAWDPPPLPERNGKIVRYVV 949

  Fly   933 QYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPIS 997
            .|  .|..:.|...|.|.:||:|:|||:|  :.|:.:.||:.:.:|              ..|||
Zfish   950 VY--RDINSHQNQTNGTADTEMTIQGLKP--DTTYDIRVRAFTGKG--------------GGPIS 996

  Fly   998 ASYQTLTAPPGKVDY---FQPSDVQPGEVTFEWSL-EPAEQHGPIDYFRITCQNADDAADVSSYE 1058
            .|.|:.|......::   |....|....|...|.: |..:...|   |:|....       .|.|
Zfish   997 PSIQSRTMSTSMPEFTKNFGVKAVMKTSVLLTWEVPETYKSQVP---FKILYNQ-------QSVE 1051

  Fly  1059 FPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAERE-HIQTMPILAPPVP-EPSVTPLEVSRTSS 1121
            ...:..:..|..|.|...|.|.:.::.....|.::: .|:|.|.|....| ...:.|.|..:.:.
Zfish  1052 VQGDLKRKLITRLQPDTDYSFVLMSRGNSAGGLQQQVSIRTAPDLFTTKPAHQKLDPEEGGKLAI 1116

  Fly  1122 TI-EISFRQGYFSNAHGMVRSYTIIIA-------------EDV------GKNASGLEMPSWQDVQ 1166
            |: |:        :...:||.:.|::.             ||:      |.|.........:..|
Zfish  1117 TLPEV--------HNSALVRWFYIVVVPVTPSTLRHWENPEDIDLDELMGNNRDAAVRRRRRQTQ 1173

  Fly  1167 AYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKI-RA 1230
            .:        :.||      ..::..|| .|.|.:|.   :|..:.|.|.||.....||..| .|
Zfish  1174 DF--------LRPY------IAAKLESL-PERFVLGD---EKTYSNYYNKPLPGQQQYRTFILAA 1220

  Fly  1231 FTDEDK-FTDTVYSSPIT----------TERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRR 1284
            ..|.|. ||.:.:|.|:.          .|..:.:.|...|.||:|:.::::.:....|    :|
Zfish  1221 LKDRDSTFTVSPFSEPMMVKLHSGMSRHVEDPEMLWVMGPVLAVVLIIIIVIAILLFKR----KR 1281

  Fly  1285 ASKLAR------MQDELAALPEGYITPNR-----------------------PVHVKDFSEHYRI 1320
            .|..|:      ::|.|.|.....:...|                       ||.|...::|...
Zfish  1282 TSPSAKDEHSAGVKDHLLAHSSDPVEMRRLNYQTQGSSAFNCPSTSRMREHPPVSVCALADHIER 1346

  Fly  1321 MSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYIN 1385
            :.|:...|||:|:|.: ..|:......:||..|:||||:.|::.|||||..|.|||...||||||
Zfish  1347 LRANDSLRFSQEYESV-DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVVLTPVDGVPGSDYIN 1410

  Fly  1386 ANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF 1450
            .||:.|:.....:|.|||||..|..:||||.||..:..|||:||..||.|.||||||| .|....
Zfish  1411 GNYIDGYRKQNAYIATQGPLPETLSDFWRMVWEQRTSTIVMMTRLEEKSRVKCDQYWP-SRGTET 1474

  Fly  1451 YGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDV 1513
            ||.|:|.::.......:|:..|.:.:|  .|.|.:|.|.|..|||.||||.|..::.|:|..:..
Zfish  1475 YGMIQVSMLDTVELATYSVRTFALYKNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRVKAC 1539

  Fly  1514 IGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIH 1578
            ...|..|::|||||||||:|.||.:|.:|:.:.....|||:|.|..||.:|.:|||||.||:.||
Zfish  1540 NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKSVDIYGHVTCMRSQRNYMVQTEDQYIFIH 1604

  Fly  1579 QCLL-AVLEGKEHLLADSLELH------ANDGYEVTKIYLE 1612
            :.|| |...|...:.|.||..|      |..|..||.:.||
Zfish  1605 EALLEAATCGNTEVPARSLYTHIQKLTQAPPGDTVTAMELE 1645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_525076.2 FN3 <94..>334 CDD:442628 43/275 (16%)
fn3 247..328 CDD:394996 9/82 (11%)
FN3 319..>749 CDD:442628 114/482 (24%)
fn3 708..796 CDD:394996 25/105 (24%)
fn3 902..978 CDD:394996 21/80 (26%)
fn3 1013..1092 CDD:394996 16/79 (20%)
PTP_tm 1127..1247 CDD:465889 30/140 (21%)
R3-PTPc 1358..1579 CDD:350396 103/222 (46%)
ptprfaXP_068077727.1 Ig strand F 210..217 CDD:409400 1/6 (17%)
Ig strand G 220..231 CDD:409400 4/17 (24%)
IgI_3_RPTP_IIa_LAR_like 241..322 CDD:409401 17/131 (13%)
Ig strand A 241..243 CDD:409401 0/1 (0%)
Ig strand A' 247..251 CDD:409401 1/3 (33%)
Ig strand B 254..262 CDD:409401 1/7 (14%)
Ig strand C 267..273 CDD:409401 1/5 (20%)
Ig strand C' 275..277 CDD:409401 1/1 (100%)
Ig strand D 280..284 CDD:409401 0/3 (0%)
Ig strand E 289..294 CDD:409401 0/4 (0%)
FN3 299..735 CDD:442628 111/497 (22%)
Ig strand F 301..308 CDD:409401 0/6 (0%)
Ig strand G 312..321 CDD:409401 1/9 (11%)
FN3 716..812 CDD:238020 24/106 (23%)
FN3 817..898 CDD:238020 17/98 (17%)
FN3 915..1003 CDD:238020 28/117 (24%)
FN3 1013..1082 CDD:238020 15/78 (19%)
PTP_DSP_cys 1340..1613 CDD:475123 121/274 (44%)
PTP_DSP_cys 1615..1905 CDD:475123 10/31 (32%)
I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 136..232 CDD:409400 23/126 (18%)
Ig strand A 136..138 CDD:409400 2/4 (50%)
Ig strand A' 143..147 CDD:409400 1/24 (4%)
Ig strand B 150..159 CDD:409400 2/8 (25%)
Ig strand C 164..170 CDD:409400 1/5 (20%)
Ig strand C' 172..174 CDD:409400 0/1 (0%)
Ig strand D 183..187 CDD:409400 0/3 (0%)
Ig strand E 196..201 CDD:409400 0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

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