Protein Alignment Ptp4E and Ptprv

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_031981.3
• Gene: Ptprv / 13924
• MGIID: 108027
• Length: 1705
• Species: Mus musculus
• Alignment Length: 1781
• Identity: 418/1781 - (23%)
• Similarity: 661/1781 - (37%)
• Gaps: 486/1781 - (27%)

  Fly    98 GFPEPNTTIPASDIGKDIKFSRALPGTEYNF--------WLYYTNSTHREQLTWTVNITTAPDPP 154
            |||| ...:.|.......:|...:||:.|..        |         :.:|.|:...|||...
Mouse    77 GFPE-GQQLQAHTNESSFEFHGLVPGSRYQLELTVLRPCW---------QNVTITLTARTAPTVV 131

  Fly   155 ANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGN-----ETLQLSAKELT 214
            ..|.:....|.::........||....:::.      |....|::|..|     :||..:..:|.
Mouse   132 RGLQLHSTGSPASLEASWSDASGDQDSYQLL------LYHPESHTLACNVSVSPDTLSYNFGDLL 190

  Fly   215 PGGSYQVQ----AYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTH 275
            ||..|.::    |.|::      |.||....|:|..|....:.....::|...|.....|   |.
Mouse   191 PGSQYVLEVITWAGSLH------AKTSILQWTEPVPPDHLTLRALGTSSLQAFWNSSEGA---TW 246

  Fly   276 YRVSITPDDAIQ--SVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLT 338
            :.:.:|  |.::  ::..|.|:    |.:...|..|.||..|.:.:...:.......|....: |
Mouse   247 FHLILT--DLLEGTNLTKVVRQ----GISTHTFLRLSPGTPYQLKICAAAGPHQIWGPNAIEW-T 304

  Fly   339 VP----ERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNV----PRAANGDS 395
            .|    :.||...::|.:.:       |:..:  ...|.|  :|..|..:.|.    |...|.
Mouse   305 YPSYPSDLVLTPLWNELWAS-------WKAGQ--GARDGY--VLKLSGPVENTTTLGPEECNA-- 356

  Fly   396 VYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTL---RPRPVRSLGGFLDDRSNALHISW-E 456
               .:|..|.||. |.:.::.:|...::| ..|.:.|   ..||:...|..|          | |
Mouse   357 ---VFPGPLPPGH-YTLGLRVLAGPYDAW-VEGSIWLAESAARPMEVPGARL----------WLE 406

  Fly   457 PAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVA 521
            ..|..:|...|...:      .|.|| .:.....:::..|..|...|:.|..|.:       .:|
Mouse   407 GLEATKQPGRRALLY------SVDAP-GLLGNISVSSGATHVTFCGLVPGAHYRV-------DIA 457

  Fly   522 SNASDITR----YTRPAAPLIQEL--RSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREER---- 576
            |:..|||:    ||.|..|...|:  |:....|.:.| :....:.:.|:|.:.::|::...
Mouse   458 SSMGDITQSLTGYTSPLPPQSLEIISRNSPSDLTIGW-APAPGQMEGYKVTWHQDGSQRSPGDLV 521

  Fly   577 TMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQ 641
            .:..:.:|||:..|.|||.|.|...|.|..:.|:.........|.||.||:|...|
Mouse   522 DLGPDISSLTLKSLVPGSCYTVSAWAWSGNLSSDSQKIHSCTRPAPPTNLSLGFAH--------- 577

  Fly   642 APEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVT 706
                                                                             
Mouse   578 ----------------------------------------------------------------- 577

  Fly   707 MPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWP----TDEEDRVEFKNVTQLEDLSSPSV 767
               ||.:          |...|..|.|..|.:.|:.:.    |.|.:::          ||..:.
Mouse   578 ---QPAT----------LRASWCHPPGGRDAFQLRLYRLRPLTLESEKI----------LSQEAQ 619

  Fly   768 RIPIEDLSPGRQYRFEVQASS--NGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYT 830
            ......|..|  |.|:||.|:  ....||:.:.:..|.|...:.|.:.:....|     :.:|:.
Mouse   620 NFSWAQLPAG--YEFQVQLSTLWGSEESGSANTTGWTPPSAPTLVNVTSEAPTQ-----LHVSWV 677

  Fly   831 PTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLY----------------NVT 879
            ....|.:.   |:.::...:.:....:........||.|||||..|                ||:
Mouse   678 HAAGDRSS---YQVTLYQESTRTATSIVGPKADSTSFWGLTPGTKYKVEAISWAGPLYTAAANVS 739

  Fly   880 VWTVSGGVASLPVQRLYRLHPLPISDLKA-IQVAAREITLHW-TAPAGEYTDFELQYLSAD---- 938
            .||                :||..::|.| :|..:..:.|.| :.|.|:.| ...|...|.
Mouse   740 AWT----------------YPLTPNELLASMQAGSAVVNLAWPSGPLGQGT-CHAQLSDAGHLSW 787

  Fly   939 EEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTL 1003
            |:...|.|::     :.|:.|.|.|..:.:|..|:|.:|.             |:.|:     .|
Mouse   788 EQPLSLGQDL-----LMLRNLIPGHTVSLSVKCRAGPLQA-------------STHPL-----VL 829

  Fly  1004 TAPPGKVD--YFQPSDVQPGEVTF---EWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNA 1063
            :..||.|:  :.||      |.|:   .|::...:                           |..
Mouse   830 SVEPGPVEDVFCQP------EATYLSLNWTMPTGD---------------------------VAV 861

  Fly  1064 TQGKIDGLVPGN--HYIFRIQAK-----------------SALGYGAEREHIQTMPILAPPVPE- 1108
            ...:::.||||.  |::|::...                 |....|..|:..:.:.::.....|
Mouse   862 CLVEVEQLVPGGSAHFVFQVNTSEDALLLPNLTPTTSYRLSLTVLGGNRQWSRAVTLVCTTSAEV 926

  Fly  1109 ---PSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPS-------WQ 1163
               |.:.........:.:.::..:|.|....|.::.|.||...::     .|..||       |.
Mouse   927 WHPPELAEAPQVELGTGMGVTVTRGMFGKDDGQIQWYGIIATINM-----TLAQPSQEAINHTWY 986

  Fly  1164 DVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKI 1228
            | ..|.....|.|:...|||.....:...|...   .:||.:||..|. .|||.|:.|..||..|
Mouse   987 D-HYYRGHDSYLALLFPNPFYPEPWAVPRSWTV---PVGTEDCDNTQE-ICNGHLKPGFQYRFSI 1046

  Fly  1229 RAFTDEDKFTDTVYSSPITTERSDTVIVAATVS----AVLLVAMVL----------VVVYCQHRC 1279
            .||:.        .|||      :|::..:..|    ::.||||.|          :::.|...|
Mouse  1047 AAFSR--------LSSP------ETILAFSAFSEPQASISLVAMPLTVMMGTVVGCIIIVCAVLC 1097

  Fly  1280 QLIRRASKLARMQ-----DELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHV 1339
            .|.||..|..|.:     .||  :|......:||:....|.:.|...||.:...|.:||||||.|
Mouse  1098 LLCRRRLKGPRSEKNGFSQEL--MPYNLWRTHRPIPSHSFRQSYEAKSARAHQAFFQEFEELKEV 1160

  Fly  1340 GRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGP 1404
            |:||....|..|.|..|||:.::|||||||.:|..:..:..|||||||::||::.|:|.|.||||
Mouse  1161 GKDQPRLEAEHPANITKNRYPHVLPYDHSRVRLTQLSGEPHSDYINANFIPGYSHPQEIIATQGP 1225

  Fly  1405 LHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSI 1469
            |..|.|:|||:.||.....|:|||...|.||..|:.||||:...:.:|.|...|:.:....:|:.
Mouse  1226 LKKTLEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPVNSTPVTHGHITTHLLAEESEDEWTR 1290

  Fly  1470 SEFMVSRNCE--SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDM--RPIIVHCSAGVG 1530
            .||.:....|  .|.::...||||||..|||.|.||:.||...::.:....  .||:||||||||
Mouse  1291 REFQLQHGAEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEEVKATQGKGPILVHCSAGVG 1355

  Fly  1531 RSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLAD 1594
            |:|||:||.|:|:.:.:...||:|..|:.:|..|..|:||..||:.:|.||| .:|||..
Mouse  1356 RTGTFVALLRLLRQLEEEQVVDVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGPS----- 1415

  Fly  1595 SLELHANDGYEVTKIYLERQPQTKMGTLPI----RASLAMAEKLDADLMTN--------KDE--- 1644
                .|:|.                |.:|:    :|....|...:|..:..        |||
Mouse  1416 ----DASDS----------------GPIPVMNFAQACAKRAANANAGFLKEYRLLKQAIKDETGS 1460

  Fly  1645 -----DEDQE-----QQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSAS 1699
                 |.:|.     ...|:||.|.                       ::.|.:|...|:|....
Mouse  1461 LLPSPDYNQNSIASCHHSQEQLALV-----------------------EESPADNMLAASLFPGG 1502

  Fly  1700 CSSSTHDVHVVLQEAIEKPKQEQERI 1725
            .|...   ||||..: ..||:..|.:
Mouse  1503 PSGRD---HVVLTGS-AGPKELWEMV 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	52/254 (20%)
		fn3	247..328	CDD:394996	15/82 (18%)
		FN3	319..>749	CDD:442628	85/455 (19%)
		fn3	708..796	CDD:394996	21/93 (23%)
		fn3	902..978	CDD:394996	20/81 (25%)
		fn3	1013..1092	CDD:394996	14/100 (14%)
		PTP_tm	1127..1247	CDD:465889	36/126 (29%)
		R3-PTPc	1358..1579	CDD:350396	96/224 (43%)
Ptprv	NP_031981.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..44
		FN3	36..110	CDD:214495	9/33 (27%)
		fn3	131..201	CDD:394996	14/75 (19%)
		FN3	378..>749	CDD:442628	97/519 (19%)
		PTP_tm	948..1069	CDD:465889	38/144 (26%)
		PTP_DSP_cys	1178..1407	CDD:475123	99/228 (43%)
		PTP_DSP_cys	1477..1692	CDD:475123	16/75 (21%)