DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptp4E and Ptprv

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_031981.3 Gene:Ptprv / 13924 MGIID:108027 Length:1705 Species:Mus musculus


Alignment Length:1781 Identity:418/1781 - (23%)
Similarity:663/1781 - (37%) Gaps:486/1781 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 GFPEPNTTIPASDIGKDIKFSRALPGTEYNF--------WLYYTNSTHREQLTWTVNITTAPDPP 154
            |||| ...:.|.......:|...:||:.|..        |         :.:|.|:...|||...
Mouse    77 GFPE-GQQLQAHTNESSFEFHGLVPGSRYQLELTVLRPCW---------QNVTITLTARTAPTVV 131

  Fly   155 ANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGN-----ETLQLSAKELT 214
            ..|.:....|.::........||....:::.      |....|::|..|     :||..:..:|.
Mouse   132 RGLQLHSTGSPASLEASWSDASGDQDSYQLL------LYHPESHTLACNVSVSPDTLSYNFGDLL 190

  Fly   215 PGGSYQVQ----AYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTH 275
            ||..|.::    |.|::      |.||....|:|..|....:.....::|...|.....|   |.
Mouse   191 PGSQYVLEVITWAGSLH------AKTSILQWTEPVPPDHLTLRALGTSSLQAFWNSSEGA---TW 246

  Fly   276 YRVSITPDDAIQ--SVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLT 338
            :.:.:|  |.::  ::..|.|:    |.:...|..|.||..|.:.:...:.......|....: |
Mouse   247 FHLILT--DLLEGTNLTKVVRQ----GISTHTFLRLSPGTPYQLKICAAAGPHQIWGPNAIEW-T 304

  Fly   339 VP----ERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNV----PRAANGDS 395
            .|    :.||...::|.:.:       |:..:  ...|.|  :|..|..:.|.    |...|.  
Mouse   305 YPSYPSDLVLTPLWNELWAS-------WKAGQ--GARDGY--VLKLSGPVENTTTLGPEECNA-- 356

  Fly   396 VYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTL---RPRPVRSLGGFLDDRSNALHISW-E 456
               .:|..|.||. |.:.::.:|...::| ..|.:.|   ..||:...|..|          | |
Mouse   357 ---VFPGPLPPGH-YTLGLRVLAGPYDAW-VEGSIWLAESAARPMEVPGARL----------WLE 406

  Fly   457 PAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVA 521
            ..|..:|...|...:      .|.|| .:.....:::..|..|...|:.|..|.:       .:|
Mouse   407 GLEATKQPGRRALLY------SVDAP-GLLGNISVSSGATHVTFCGLVPGAHYRV-------DIA 457

  Fly   522 SNASDITR----YTRPAAPLIQEL--RSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREER---- 576
            |:..|||:    ||.|..|...|:  |:....|.:.| :....:.:.|:|.:.::|::...    
Mouse   458 SSMGDITQSLTGYTSPLPPQSLEIISRNSPSDLTIGW-APAPGQMEGYKVTWHQDGSQRSPGDLV 521

  Fly   577 TMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQ 641
            .:..:.:|||:..|.|||.|.|...|.|..:.|:.........|.||.||:|...|         
Mouse   522 DLGPDISSLTLKSLVPGSCYTVSAWAWSGNLSSDSQKIHSCTRPAPPTNLSLGFAH--------- 577

  Fly   642 APEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVT 706
                                                                             
Mouse   578 ----------------------------------------------------------------- 577

  Fly   707 MPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWP----TDEEDRVEFKNVTQLEDLSSPSV 767
               ||.:          |...|..|.|..|.:.|:.:.    |.|.:::          ||..:.
Mouse   578 ---QPAT----------LRASWCHPPGGRDAFQLRLYRLRPLTLESEKI----------LSQEAQ 619

  Fly   768 RIPIEDLSPGRQYRFEVQASS--NGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYT 830
            ......|..|  |.|:||.|:  ....||:.:.:..|.|...:.|.:.:....|     :.:|:.
Mouse   620 NFSWAQLPAG--YEFQVQLSTLWGSEESGSANTTGWTPPSAPTLVNVTSEAPTQ-----LHVSWV 677

  Fly   831 PTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLY----------------NVT 879
            ....|.:.   |:.::...:.:....:........||.|||||..|                ||:
Mouse   678 HAAGDRSS---YQVTLYQESTRTATSIVGPKADSTSFWGLTPGTKYKVEAISWAGPLYTAAANVS 739

  Fly   880 VWTVSGGVASLPVQRLYRLHPLPISDLKA-IQVAAREITLHW-TAPAGEYTDF----ELQYLSAD 938
            .||                :||..::|.| :|..:..:.|.| :.|.|:.|..    :..:||. 
Mouse   740 AWT----------------YPLTPNELLASMQAGSAVVNLAWPSGPLGQGTCHAQLSDAGHLSW- 787

  Fly   939 EEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTL 1003
            |:...|.|::     :.|:.|.|.|..:.:|..|:|.:|.             |:.|:     .|
Mouse   788 EQPLSLGQDL-----LMLRNLIPGHTVSLSVKCRAGPLQA-------------STHPL-----VL 829

  Fly  1004 TAPPGKVD--YFQPSDVQPGEVTF---EWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNA 1063
            :..||.|:  :.||      |.|:   .|::...:                           |..
Mouse   830 SVEPGPVEDVFCQP------EATYLSLNWTMPTGD---------------------------VAV 861

  Fly  1064 TQGKIDGLVPGN--HYIFRIQAK-----------------SALGYGAEREHIQTMPILAPPVPE- 1108
            ...:::.||||.  |::|::...                 |....|..|:..:.:.::.....| 
Mouse   862 CLVEVEQLVPGGSAHFVFQVNTSEDALLLPNLTPTTSYRLSLTVLGGNRQWSRAVTLVCTTSAEV 926

  Fly  1109 ---PSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPS-------WQ 1163
               |.:.........:.:.::..:|.|....|.::.|.||...::     .|..||       |.
Mouse   927 WHPPELAEAPQVELGTGMGVTVTRGMFGKDDGQIQWYGIIATINM-----TLAQPSQEAINHTWY 986

  Fly  1164 DVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKI 1228
            | ..|.....|.|:...|||.....:...|...   .:||.:||..|. .|||.|:.|..||..|
Mouse   987 D-HYYRGHDSYLALLFPNPFYPEPWAVPRSWTV---PVGTEDCDNTQE-ICNGHLKPGFQYRFSI 1046

  Fly  1229 RAFTDEDKFTDTVYSSPITTERSDTVIVAATVS----AVLLVAMVL----------VVVYCQHRC 1279
            .||:.        .|||      :|::..:..|    ::.||||.|          :::.|...|
Mouse  1047 AAFSR--------LSSP------ETILAFSAFSEPQASISLVAMPLTVMMGTVVGCIIIVCAVLC 1097

  Fly  1280 QLIRRASKLARMQ-----DELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHV 1339
            .|.||..|..|.:     .||  :|......:||:....|.:.|...||.:...|.:||||||.|
Mouse  1098 LLCRRRLKGPRSEKNGFSQEL--MPYNLWRTHRPIPSHSFRQSYEAKSARAHQAFFQEFEELKEV 1160

  Fly  1340 GRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGP 1404
            |:||....|..|.|..|||:.::|||||||.:|..:..:..|||||||::||::.|:|.|.||||
Mouse  1161 GKDQPRLEAEHPANITKNRYPHVLPYDHSRVRLTQLSGEPHSDYINANFIPGYSHPQEIIATQGP 1225

  Fly  1405 LHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSI 1469
            |..|.|:|||:.||.....|:|||...|.||..|:.||||:...:.:|.|...|:.:....:|:.
Mouse  1226 LKKTLEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPVNSTPVTHGHITTHLLAEESEDEWTR 1290

  Fly  1470 SEFMVSRNCE--SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDM--RPIIVHCSAGVG 1530
            .||.:....|  .|.::...||||||..|||.|.||:.||...::.:....  .||:||||||||
Mouse  1291 REFQLQHGAEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEEVKATQGKGPILVHCSAGVG 1355

  Fly  1531 RSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLAD 1594
            |:|||:||.|:|:.:.:...||:|..|:.:|..|..|:||..||:.:|.||| .:|||..     
Mouse  1356 RTGTFVALLRLLRQLEEEQVVDVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGPS----- 1415

  Fly  1595 SLELHANDGYEVTKIYLERQPQTKMGTLPI----RASLAMAEKLDADLMTN--------KDE--- 1644
                .|:|.                |.:|:    :|....|...:|..:..        |||   
Mouse  1416 ----DASDS----------------GPIPVMNFAQACAKRAANANAGFLKEYRLLKQAIKDETGS 1460

  Fly  1645 -----DEDQE-----QQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSAS 1699
                 |.:|.     ...|:||.|.                       ::.|.:|...|:|....
Mouse  1461 LLPSPDYNQNSIASCHHSQEQLALV-----------------------EESPADNMLAASLFPGG 1502

  Fly  1700 CSSSTHDVHVVLQEAIEKPKQEQERI 1725
            .|...   ||||..: ..||:..|.:
Mouse  1503 PSGRD---HVVLTGS-AGPKELWEMV 1524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 20/99 (20%)
fn3 247..328 CDD:278470 15/82 (18%)
fn3 343..417 CDD:278470 16/77 (21%)
fn3 443..525 CDD:278470 16/82 (20%)
FN3 548..611 CDD:238020 17/66 (26%)
FN3 620..706 CDD:238020 7/85 (8%)
fn3 708..796 CDD:278470 21/93 (23%)
fn3 824..886 CDD:278470 15/77 (19%)
fn3 902..978 CDD:278470 20/81 (25%)
fn3 1013..1092 CDD:278470 14/100 (14%)
UP_III_II 1106..>1248 CDD:297589 38/152 (25%)
PTPc 1329..1582 CDD:214550 114/256 (45%)
PTPc 1355..1582 CDD:238006 100/230 (43%)
PtprvNP_031981.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..44
fn3 36..109 CDD:278470 9/32 (28%)
fn3 131..201 CDD:278470 14/75 (19%)
FN3 218..288 CDD:214495 16/78 (21%)
FN3 473..551 CDD:214495 20/78 (26%)
FN3 656..730 CDD:238020 14/81 (17%)
fn3 834..913 CDD:278470 17/111 (15%)
PTPc 1150..1408 CDD:214550 115/257 (45%)
PTPc 1176..1408 CDD:238006 101/231 (44%)
Substrate binding. /evidence=ECO:0000250 1350..1356 5/5 (100%)
PTPc <1521..1692 CDD:304379 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19134
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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