Protein Alignment Ptp4E and Ptp52F

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_061510830.1
• Gene: Ptp52F / 1280988
• VectorBaseID: AGAMI1_010367
• Length: 1478
• Species: Anopheles gambiae
• Alignment Length: 1391
• Identity: 331/1391 - (23%)
• Similarity: 533/1391 - (38%)
• Gaps: 342/1391 - (24%)

  Fly   393 GDSVY-FDYPDI----LEPGRTYEVVVKTIADNV--------------------NSWPASGEVTL 432
            |.||. .|.|.:    |:.|:.|.||:|.|..|.                    |.|....|..:
Mosquito   185 GSSVIPLDIPFVGMSGLQGGKKYRVVLKIICINAGKVQHLLEIYVKSPVKQTTPNPWRCGLEFYV 249

  Fly   433 RPRPVRSLGGFLDDRSNAL---HISWEPAET-------GRQDSYRISYHEQTNASEV---PAPFP 484
            :.|  ..:|..::|.....   ||: .|..|       .|::||:...|.:.:.|:.   |...|
Mosquito   250 QHR--NGIGEVINDNPKTFQFYHIA-RPITTRKVCSKEARKESYKTKTHGKLSVSDTNFQPNRVP 311

  Fly   485 V-AAESQITTNLTEYTLDSLLAGR---RYLIAVQALSKGVASNASDITRYTRP--AAPLIQELRS 543
            | .:..|:..:....|....|...   :.|.|:..|..|:.:.:|......:|  ..| :::||:
Mosquito   312 VDVSTPQLPLDYFAKTSHIELPSNAIPKVLSAIPPLCPGLRARSSSGDAIIKPQTVGP-VRDLRA 375

  Fly   544 ---IDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISH 605
               :|:.::||||..........|  |....:.|..|:..:.|...:..|.|...||..|:||.|
Mosquito   376 NTDLDRSVLLSWRPPKEGAVCVKE--YLITWSSESATIDASRTVYNVTNLEPCMTYEFTVNAIDH 438

  Fly   606 -GVRSEPHSYFQAVFPKPPQNLT------LQTVHTNLVVLHWQAPEGSDF---SEYVVRYRTDAS 660
             ..:..|.|....|  :..|.|:      |..|....:.:.|:.|....|   |..||.:..:.:
Mosquito   439 TNDKGTPESISATV--RELQQLSQVTELELNEVEPRSLSVKWKPPTNGTFCVESYRVVAWYNNPA 501

  Fly   661 PWQRISGLHENEARIKDMHYGE-----RYLVQVNTVS----------------------FGVE-- 696
            ....::.:..|....:.:.:||     .|.|||..:|                      :.||
Mosquito   502 NSADVTEVFSNTTTDQHVTFGEVIACMSYTVQVIPISISKHDGLNEIGTIKTKERTILFYHVEPI 566

  Fly   697 -----SPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNV 756
                 |...|||:..:..:..:|.:.:.                               |.|...
Mosquito   567 RAIALSSRSLELSTMLHSENNNNCLLVT-------------------------------VAFNCT 600

  Fly   757 TQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQ 821
            ..:|.:..|..::..|.:.|.....||      ||          ..||:....:..||     :
Mosquito   601 KMVEGVPVPESQVIKEFVIPNGNTTFE------GI----------VEPLVPYSTYECNA-----K 644

  Fly   822 DETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNV-TVW---T 882
            .:.|.....||||       |.|           ..|.|.....|...|. ||..:: .:|   |
Mosquito   645 IQNIAGWSDPTPA-------YTF-----------VTAEDVPESPSVIELI-GKNRSIGIIWKAPT 690

  Fly   883 VSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITL-HWTAPAGEYTDFELQYLSADEEAPQLLQ 946
            |..||    |.| ||:|         :::.|.|..| ...||..|:           .|...|..
Mosquito   691 VKNGV----VVR-YRIH---------VRMVAPEYPLPKLCAPLEEF-----------NETVDLRD 730

  Fly   947 NVTKNTEITLQG---------LRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQT 1002
            .|..:...:..|         |.||..|...|...:|:..|.....|.|.||...| .::||::.
Mosquito   731 EVNPDESRSWDGIEFEHVVAKLNPYTLYLVQVAAATGAGFGPYTEPVEVVTLPDVS-NVTASFRI 794

  Fly  1003 LTAPPGKVDYFQPSDVQPGEVTFEWSL---------------------EPAEQHGPIDYFRITCQ 1046
                 .|::..:.:......|.|.|.|                     :|:..|...  :.:...
Mosquito   795 -----DKIEGPELNQTYKSSVWFGWDLPCGLNGRLKRFVGEMYGIREQDPSNPHALT--WEVNVG 852

  Fly  1047 NADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAK-SALGYGAEREHIQ-TMPILAPPVPEP 1109
            ..::..||.||         ..|.|.|..:|...|:.: .|:...::...:| ..|...|.:.:.
Mosquito   853 EEEEILDVYSY---------VEDRLKPEYNYTVAIRVEVVAVEELSDEVKVQFESPAGIPSIDQK 908

  Fly  1110 ----SVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAE-----------DVGKNASGLEM 1159
                :|...|....::|..|.......::..|.:|...::::|           |...:..|.:.
Mosquito   909 EEWFNVDVFEAPNPTNTARIMLGNITLTSDIGSIRYMALLVSERLCQPDPTPRTDFINSTGGTQW 973

  Fly  1160 PSWQDVQAYTVWLPYQAIEP------------YNPFLTSNGSRKSS-LEAE---HFTIGTANCDK 1208
            ||..|      |  |.|.|.            :||.  :.|.|.:: .||.   .:.||..:||:
Mosquito   974 PSVPD------W--YLANEKRCAEQYQTTPKFWNPM--ARGQRATTDREAAGLIEYVIGKEDCDR 1028

  Fly  1209 HQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVI-VAATVSAVLLVAMV--- 1269
            .|. ||||||:.||.|.:.:|.|: ...:||    |.:...|:|::| |...|||||...::
Mosquito  1029 GQE-YCNGPLKPGTEYALIVRIFS-RSGYTD----SEMQVFRTDSLIKVGLIVSAVLACLVLAFL 1087

  Fly  1270 --LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEE 1332
              |.||:.:.|..|..:.::.| ..:|.|.:|           ||:|...|..:...:..:.|:|
Mosquito  1088 GGLFVVWRKQRLLLPAQQTRGA-PTEEPADIP-----------VKNFPHQYDELFQSNREKVSKE 1140

  Fly  1333 FEELKH---VGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDD-----GSDYINANYM 1389
            |:.:.:   .......||.:...|..|||:.||||||.:|..|...:|.:     .:|||||:::
Mosquito  1141 FQAINYFSDFALQDTVSFQSARENERKNRYVNILPYDSNRVLLDSNEDGEEGEYGANDYINASFI 1205

  Fly  1390 PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDI 1454
            .|:...||:|.||||...|..:||||..:....:|||||:..:..:.||.||:|.......||||
Mosquito  1206 EGYKYQREYIATQGPKQETCADFWRMVLQYEIESIVMLTQPIDHDKNKCCQYFPRFDQYTDYGDI 1270

  Fly  1455 KVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR 1519
            :|:...:.:...:....|:||:...::.:.|:||..|||...|.....|::|.:..|....:...
Mosquito  1271 RVKCTQELNLSLYYKRLFLVSKGNLTKAVFHYHFLEWPDHSCPASTADLIKFSKIVRAERKSYAI 1335

  Fly  1520 PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV 1584
            |::|||||||||:|||||||.:||.:.:...::::..|..:|::||.||||..||..::||.:..
Mosquito  1336 PLVVHCSAGVGRTGTFIALDIVLQRLQQEKKINVYDTVKQLRRQRVKMVQTLDQYTFLYQCCMEY 1400

  Fly  1585 L--------------------EGKEH 1590
            :                    :||:|
Mosquito  1401 VSKSNRKKPKTSNIEIIRRDEKGKQH 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	89/446 (20%)
		fn3	708..796	CDD:394996	11/87 (13%)
		fn3	902..978	CDD:394996	16/85 (19%)
		fn3	1013..1092	CDD:394996	16/100 (16%)
		PTP_tm	1127..1247	CDD:465889	37/146 (25%)
		R3-PTPc	1358..1579	CDD:350396	85/225 (38%)
Ptp52F	XP_061510830.1	None