Protein Alignment Ptp4E and Lar

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_061516302.1
• Gene: Lar / 1279520
• VectorBaseID: AGAMI1_014585
• Length: 2049
• Species: Anopheles gambiae
• Alignment Length: 1765
• Identity: 410/1765 - (23%)
• Similarity: 657/1765 - (37%)
• Gaps: 527/1765 - (29%)

  Fly    88 FYRIDYSPPFGFPEPNTTIPASDIGKDIKF---SRAL-PGTEYNFWLYYTNSTHREQLTWTVNIT 148
            :|.|.|.|      .|.....|:|...|..   .|.| |.|||.|::...|:..|...:.....|
Mosquito   366 YYVIQYKP------KNANQAFSEISGIITMFYVVRTLSPYTEYEFYVIAVNNIGRGPPSLPATTT 424

  Fly   149 TA------------PDPPANLSVQLRSSKSAFITWRPP--GSGRYSGFRIRVLGLTDLPFERSY- 198
            |.            ...|.|:.|:..||.:..|||.||  .:|:.:|:::......:.| |.|:
Mosquito   425 TGETGDSAYGGSKMESAPRNIEVKPLSSSTMLITWEPPETPNGQVTGYKVYYTTNPNQP-EASWD 488

  Fly   199 -SLEGNETLQLSAKELTPGGSY--QVQAY-SVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETT 259
             .:|.|:...:|  ||||...|  :|||: |:..|..|.....:.....|:.|..|......||.
Mosquito   489 SQMETNDMTTIS--ELTPHAIYTIRVQAFTSMGAGPLSNPVQVKAQQGVPSQPSNFRATDVGETA 551

  Fly   260 LLVLWQPPFPAG-------IY---------THYRVSITPDDAIQSV----LYV------EREGE- 297
            :.:.|..|..:|       :|         .|.|:..|....:.|:    ||.      .:.||
Mosquito   552 VTLQWSRPTHSGENIVHYELYWNDTYANEQHHQRIPNTETYTLSSLYPDTLYYFWLSARSQRGEG 616

  Fly   298 ---PPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFR 359
               ||.|.:.  |..|||                          .|.|  |||.:.  |:.::..
Mosquito   617 ATTPPIPVRT--KQYVPG--------------------------APPR--NVTVEA--TSPTTIN 649

  Fly   360 VRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRT-YEVVVKT------I 417
            |.|.||..                     ..:||..||:.. ..:|.||: .|..|.|      :
Mosquito   650 VSWLPPPV---------------------ERSNGAIVYYKV-FFVEVGRSDSEATVTTLNSTSIV 692

  Fly   418 ADNVNSW----------------PASGEVTLR--------PRPVRSLGGFLDDRSNALHISWEPA 458
            .|.:..|                |.|...|:|        |:.|::    ....|..::::|:|.
Mosquito   693 LDELKRWTEYKIWVLAGTSVGDGPRSYPYTVRTHEDVPGDPQDVKA----SPVNSTTIYVTWKPP 753

  Fly   459 ETGRQDSYRISYH--------EQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQA 515
            :...::.....||        |.......|..|.|       .:..||.:..|....:|.:.|.|
Mosquito   754 KEKNRNGIIRGYHIHVQEMKEEGKGLLNEPMKFDV-------VDGLEYNVTGLQPDTKYSVQVAA 811

  Fly   516 LS-KGVASNASDITRYT------RPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVH-YQ-RNG 571
            |: ||....::.|:..|      ||...|....|.....:.|.|.   ..||...|:. |: |.|
Mosquito   812 LTRKGDGDRSAPISVKTPGGVPIRPTVTLKILERDPTVSIELEWE---RPRQTYGELRGYRVRWG 873

  Fly   572 TREERTMATNETSL--------TIHYLHPGSGYEVKVHAISH-GVRSEPHSYFQAVFPK-----P 622
            .||:   |.||..|        .|:.|..|..||.:|..::| |:..|...:.|.  |:     |
Mosquito   874 VREQ---ALNEEILQGTQLNVKRINDLERGVEYEFRVAGMNHIGIGQEAVKHLQT--PEGSPTGP 933

  Fly   623 PQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRIS---GLHEN----EARIKDMHY 680
            |..:.::....::|.:.|:.|.....:..:.||  |....::|.   |...|    :|...::..
Mosquito   934 PTGIAVRFQTPDVVCITWEPPTREHRNGQITRY--DVQFHKKIDHGLGTERNTTVRKAVFTNLDE 996

  Fly   681 GERYLVQVNTVSFGVESPHPLELNVTMPPQ------PVSNVVPLVDSRNLTLE--W-PRPD---- 732
            ...|:|:|.  ::..:...|....|.:..:      |.|  |..|.:...|:|  | |.|.
Mosquito   997 STEYIVRVR--AYTKQGAGPFSEKVVIATERDMGRAPFS--VQAVATSEQTVEVWWEPVPSRGKL 1057

  Fly   733 -GHVDFYTLKWWPTDEEDRVEFK----NVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIR 792
             |:..|||:    |..||..|::    .||:..||      |.:|..:   ||...:.|.   .:
Mosquito  1058 VGYKIFYTM----TAVEDLDEWQTKVVGVTESADL------INLEKFA---QYAVAIAAM---YK 1106

  Fly   793 SGTTHLSTR-TMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEK 856
            :|...||.: |:.:...||.:....|:. ...::|||:.                  |.|:
Mosquito  1107 TGLGKLSEKATVKVKPEDVPLNLRAHDV-STHSMTLSWA------------------PPIR---- 1148

  Fly   857 LANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWT 921
             .|....|:||..        |..:..|.|::...:        ||..::
Mosquito  1149 -MNPINYKISFDA--------VKEFVDSQGISQKQI--------LPRKEI--------------- 1181

  Fly   922 APAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDF----- 981
                                  :|::..|:.  |:..|.|:..|...|     |...||:
Mosquito  1182 ----------------------ILKSHVKSH--TISELSPFTTYFVNV-----SAVPTDYSYKPP 1217

  Fly   982 ADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQ 1046
            |.::|:|.|  :||     |.:..|    |::   .|..||.......:.:|::|||.::.:...
Mosquito  1218 AKITVTTQM--AAP-----QPMVQP----DFY---GVVNGEEIQVILPQASEEYGPISHYYLIVV 1268

  Fly  1047 NADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSV 1111
            ..|.|   :.::.|   .|...:.|:|....:.|:.|                         |.:
Mosquito  1269 PEDKA---NLHKIP---DQFLTEELLPSRPKLDRLNA-------------------------PYI 1302

  Fly  1112 TPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQA 1176
            ..:.:.|.                                                    :||.
Mosquito  1303 AAMFLQRN----------------------------------------------------IPYT- 1314

  Fly  1177 IEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDK---FT 1238
                                  |.:|:...:.:   :.|..|..|..|||.:||..|..:   :|
Mosquito  1315 ----------------------FHLGSGETNHN---FTNKKLERGKRYRIFVRAVVDTPQKHLYT 1354

  Fly  1239 DTVYS-------------------SPITTERSDTVI------------VAATVSAVLLVAMVLVV 1272
            .:.:|                   :|...:.::.:|            |...::|::|....|||
Mosquito  1355 SSPFSEFLALDMKEAPTGEPPHRPNPNVPQDTEIIIRGKNEEPGMLWVVGPIIAALVLSVCFLVV 1419

  Fly  1273 VYCQHRCQLIRRASKLA----RMQDELAALPE----------GYITP----NRPVHVKDFSEHYR 1319
            .:.:.|.|..:...:.|    .|..:|.|.|.          .:.||    :.|:.:.:.:.|..
Mosquito  1420 YFVRRRRQPCKAPDQAAVTRPLMAADLGAGPAPTDPVDMRRINFQTPGMISHPPISIAELANHVE 1484

  Fly  1320 IMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYI 1384
            .:.|:.:.:||:|:|.:: .|:......:|:..|:||||:.|:..|||||..|.|::...|||||
Mosquito  1485 RLKANDNLKFSQEYESIE-PGQQFTWDHSNMEVNKPKNRYANVTSYDHSRVILPPIEGVPGSDYI 1548

  Fly  1385 NANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAM 1449
            ||||..|:.....::.|||||..|..:|||||||..|..|||:||..|:.|.|||.|||. |...
Mosquito  1549 NANYCDGYRKHNAYVATQGPLQETFGDFWRMCWELKSSTIVMMTRLEERSRIKCDMYWPA-RGTE 1612

  Fly  1450 FYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRD 1512
            .||.:.|.:........:||..|.:.||  .|.|.::...||.|||.|||:.|...::|:|..:.
Mosquito  1613 VYGAMTVTITETQELATYSIRTFQIYRNGSNERREIKQLQFTAWPDHGVPDHPAPFLQFLRRTKS 1677

  Fly  1513 VIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCI 1577
            :..::..||||||||||||:|.:|.:|.:|:.:.....:||:|.|..:|.:|.:|||||.||:.|
Mosquito  1678 LTPSESGPIIVHCSAGVGRTGCYIVIDSMLERMKYEKTIDIYGHVTCLRAQRNYMVQTEDQYIFI 1742

  Fly  1578 HQCLL-AVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLD------ 1635
            |..|| ||:.|...:.|.||..|      :.|: ::.:|...:..:.:........|.|
Mosquito  1743 HDALLEAVICGSTEVPARSLHNH------IQKL-MQTEPHENITGMEMEYKKLSNVKADSTRFVT 1800

  Fly  1636 ADLMTNKDED 1645
            |:|..||.::
Mosquito  1801 ANLPCNKHKN 1810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	69/292 (24%)
		fn3	247..328	CDD:394996	23/110 (21%)
		FN3	319..>749	CDD:442628	108/512 (21%)
		fn3	708..796	CDD:394996	27/105 (26%)
		fn3	902..978	CDD:394996	9/75 (12%)
		fn3	1013..1092	CDD:394996	15/78 (19%)
		PTP_tm	1127..1247	CDD:465889	16/141 (11%)
		R3-PTPc	1358..1579	CDD:350396	98/222 (44%)
Lar	XP_061516302.1	None