Protein Alignment Ptp4E and Ptp99A

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_061501554.1
• Gene: Ptp99A / 1273129
• VectorBaseID: AGAMI1_003145
• Length: 1346
• Species: Anopheles gambiae
• Alignment Length: 1079
• Identity: 260/1079 - (24%)
• Similarity: 425/1079 - (39%)
• Gaps: 296/1079 - (27%)

  Fly   781 RFEVQASSNGI------------RSGTTHL-STRTMPLIQSDVFIANAGHEQGQDETITL----- 827
            |:.:.|..|.|            .|||:.: ....:|:::   ::|.||      :.|||
Mosquito     2 RYSIAAQWNFIVCGLILAASFITGSGTSRIFDIENIPVVK---YVAVAG------KNITLDCPGV 57

  Fly   828 ---SYTPTPADSTRFDIYRFSMGDPTIKDKE--------------KLANDTERKLSFSGL----- 870
               |...|....|...|..:..|.|.:.::.              .:|:||   ..:|.|
Mosquito    58 NERSLVETLVWRTSHTIAEYVNGLPLVSNQRLTLLGDNFSLILSPAIASDT---AEYSCLLNDRH 119

  Fly   871 TPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHW-------TAPA---- 924
            :|..:.::.|..|                |.|......:...:|.:.|.|       .||.
Mosquito   120 SPEAIVDLLVQDV----------------PDPPGRPLVVSFTSRSVDLSWAHSQDPRNAPVTNFI 168

  Fly   925 -----GEYTDFELQYLSADEEAPQLLQNVTKNTEITLQ--GLRPYHNYTFTVVVRSGSIQGTDFA 982
                 ||..|:|       :|.|    ..||:::...|  ||:|:..|:|.|
Mosquito   169 IETRIGENGDWE-------QEPP----IHTKSSQAAHQVTGLQPFTVYSFRV------------- 209

  Fly   983 DVSVSTLMRSSAPISASYQTLT---APPGKVDYFQPSDVQPGEVTFEWSLEPAEQ---------- 1034
             ::|:.| ..|.|...||..:|   ||.||.......:.....|...|...|.|.
Mosquito   210 -IAVNKL-GHSPPSKESYYFVTLREAPTGKPVTTIAHNTSATSVYISWKAPPPESILGEFLGYRI 272

  Fly  1035 -HGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQT 1098
             :.|.||      :.||..::  |.........:|..|.....|:..||..:..|.|.... :..
Mosquito   273 TYRPRDY------HTDDVKEI--YIRDSTVENHEIHNLETYTQYLVSIQVFNPEGLGPPTT-VLV 328

  Fly  1099 MPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMP--- 1160
            |.....|.|..::|.|||  ||:||::::|:.  ..|:|.:..|.:..   :.:|.:.|.||
Mosquito   329 MTDEGEPSPPQNLTVLEV--TSTTIKLTWREP--EKANGAIHGYRVYY---IHQNQTDLHMPILK 386

  Fly  1161 ---SWQDVQAYTVWLPYQAIEPYNPF--LTSNGSRKSSLEAEHFT------------IGTANCDK 1208
               ....|..||:    ..::|:..:  |.:..::|...:....|            :....|..
Mosquito   387 LNEMQNSVYHYTL----SNLKPFTEYRILVTAFTKKHDGKPSEVTQRTDVSGPSAPKVVNLTCHS 447

  Fly  1209 HQAGY----------------------------------CNGP----------LRAGTTYRIKIR 1229
            |.|.|                                  .|..          |.:...|.:|:|
Mosquito   448 HNALYYGWRIPQTFYNTIDLYIISYRNIAYHEFREIRITVNASIMETSLIIPNLTSNAVYEVKVR 512

  Fly  1230 A---------------FTDEDKFT--DTVYSSPITTERS-----DTVIVAATV---SAVLLVAMV 1269
            |               :::..|.:  .....:|:.::|.     |..::|..|   |.|||:|:.
Mosquito   513 AASTSVINPKQMILGSYSEPRKISLQPNCEKAPLKSQRQAYDDYDLAVLAGIVFSCSVVLLIALA 577

  Fly  1270 LVV-VYCQHR----------CQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSA 1323
            |:: ..|.|.          ||..:..........|:.....|      ||.|.||::|...:.|
Mosquito   578 LILWKKCFHAAYYYLDDPQPCQGAQAGLIDWEAPSEIGGEVRG------PVAVADFAKHVAQLHA 636

  Fly  1324 DSDFRFSEEFEELKHVGRDQACSFANL--PCNRPKNRFTNILPYDHSRFKLQPVDDDDGS-DYIN 1385
            |.|..||:|:|.::....:......|.  |.|:.|||:.|::.|||||..|:.|...... ||||
Mosquito   637 DGDIGFSKEYEAIQGEALNDEYPSENSQHPENKGKNRYLNVIAYDHSRVHLRQVPGQKKHLDYIN 701

  Fly  1386 ANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF 1450
            ||::.|:..||.||.|||||..|.:.||||.||.....|||:|...|:||.|||.|||.|....
Mosquito   702 ANFIDGYQKPRAFIGTQGPLPGTFDCFWRMVWEQRVAVIVMITNLVERGRRKCDMYWPKDGTET- 765

  Fly  1451 YGDIKVQLIIDTHYHDWS-----ISEFMVSRNCESRIMR---HFHFTTWPDFGVPEPPQSLVRFV 1507
            ||.|:|:|:.:.....::     |....:.:..:|::.:   .:|:|.|||.|.|:.|..::.||
Mosquito   766 YGIIQVRLVKEDVMATYTVRTLHIKHLKMKKKKQSQMEKTVYQYHYTNWPDHGTPDHPLPVINFV 830

  Fly  1508 RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQ 1572
            :........|..||:|||||||||:||||.||.:|:.|.....:::||.:..:|.:|.::||||:
Mosquito   831 KKSTTANLPDGGPIVVHCSAGVGRTGTFIVLDAMLKQIEAKGSLNVFGFLRYIRAQRNYLVQTEE 895

  Fly  1573 QYVCIHQCLL-AVLEGKEHLLADSLELHANDGYEVTKI-YLERQPQTKMGTLPIRASLAMAEKLD 1635
            ||:.||..|: |:..|:.::..|::      |..|..: |::.|.:..:.:.|:     ..:::|
Mosquito   896 QYIFIHDALVEAITSGETNIKMDAI------GGLVNHLDYIDAQYKVSVDSTPV-----FCDQID 949

  Fly  1636 A----------DLMTNKDEDEDQEQQQQQQLQLATEVKP 1664
            :          .|:.:         .|.:::.|.:.:||
Mosquito   950 SFSGFCSFLLRQLIVS---------YQPKEINLTSSLKP 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996	6/26 (23%)
		fn3	902..978	CDD:394996	21/93 (23%)
		fn3	1013..1092	CDD:394996	17/89 (19%)
		PTP_tm	1127..1247	CDD:465889	27/200 (14%)
		R3-PTPc	1358..1579	CDD:350396	94/229 (41%)
Ptp99A	XP_061501554.1	None