DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and ptprh

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_012822947.2	Gene:	ptprh / 101733801	XenbaseID:	XB-GENE-992810	Length:	1327	Species:	Xenopus tropicalis

Alignment Length:	1449	Identity:	389/1449 - (26%)
Similarity:	614/1449 - (42%)	Gaps:	258/1449 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 GSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSIT 281
            |...|.|.||....:||:.:  |.||               |.:.:.|.||......| |..|||
Frog    26 GGTPVAAQSVPSPVQSVSIS--NITT---------------TNVTLSWVPPNDTDKDT-YTYSIT 72

  Fly   282 PDDAIQSVLYVEREGEPP-------GPAQAAFKGLVPGREYNISVQTVSEDET-SSVPTTARYLT 338
                    :|   .|..|       ........||:||..|..||.||:.:.| ||...:....|
Frog    73 --------VY---NGSSPWNLPKNISGTSTQVTGLMPGVFYTFSVFTVTSNGTMSSQNGSISGTT 126

  Fly   339 VPERVLNVTFDEAYTTSSSFRVRWEPPR-----TYSEFDAYQVMLSTSRRIFNVPRAANGDSVYF 398
            ||..|.:|:.....||:.:  :.|.||.     ||:    |.:.:......::.|:..:|.|...
Frog   127 VPSPVQSVSVSNITTTNVT--LSWVPPNDINKDTYT----YSITVYNGSSPWDWPKNISGTSTQV 185

  Fly   399 DYPDILEPGRTYEVVVKTIADN--VNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETG 461
            ..   |.||..|...|.|:..|  ::|...|...|..|.||:|: ...:..:..:.:||.|....
Frog   186 TG---LIPGVFYTFSVFTVTSNGTMSSQAGSTSGTTVPSPVQSV-SISNIMTTNVTLSWVPPNDI 246

  Fly   462 RQDSYRISYHEQTNASEVPAPFPVAAES-QITTNLTEYTLDSLLAGRRYLIAV-QALSKGVASNA 524
            .:|:|..|......::....|..::..| |:|         .|:.|..|..:| ...|.|..|:.
Frog   247 NKDTYTYSITVYNGSTSWNGPTNISGTSTQVT---------GLIPGVYYTFSVFTVTSNGTKSSQ 302

  Fly   525 SDITRYTRPAAPL--IQELRSIDQGLMLSW--RSDVNSRQDRYEVHYQRNGTREERTMATNETSL 585
            :..|..|...:|:  :.....:...:.|||  .:|:|.....|.:......:........:.||.
Frog   303 AGSTSGTTVPSPVQSVSISNIMTTNVTLSWVPPNDINKDTYTYSITVSNGSSPWNGPKNISGTST 367

  Fly   586 TIHYLHPGSGYEVKVHAI-SHGVRSEPH-SYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPE--GS 646
            .:..|.||..|...|..: |:|..|..: |......|.|.::||:.:.....:.|.|..|.  .|
Frog   368 LVTGLIPGVYYTFSVFTVTSNGTMSSQNGSTSGTTEPLPAKDLTITSRTMTTLNLSWTPPNDINS 432

  Fly   647 DFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQV------NTVSFGVESPHPLELNV 705
            :...|.:.....::.|...:..:.|.|::.|:..|..|.:.|      .|:|.||:|     :..
Frog   433 NTYSYSINLSNGSTTWNITTPKNANSAQVTDLLPGVTYTISVYTLTSSGTISSGVDS-----IKG 492

  Fly   706 TMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFK------------NVTQ 758
            |..|..|:.|..:..:.|..             |:.|.|..:.::..:.            ||..
Frog   493 TTRPSLVTTVSIIKQTNNSV-------------TISWTPPQDINQATYMYSINVTNSAGSWNVNS 544

  Fly   759 LEDLSSPSVRIPIEDLSPGRQYRFEV-QASSNGIRSG-TTHLSTRTMPLIQSDVFIANAGHEQGQ 821
            ..::||..|.    ||.||..|.|.| ..:|:|.:|. .:..|:.|.|.:..||.:     :...
Frog   545 STNVSSKEVL----DLLPGVTYTFCVYTVTSDGTKSSDCSPDSSTTRPTLVKDVTV-----KSQT 600

  Fly   822 DETITLSYTPTPADSTRFDIYRF---SMGDPTIKDKEKLANDT--ERKLSFSGLTPGKLYNVTVW 881
            .:::|||:| ||.|..:...|..   :.|..|..     .|.|  ....:.:.|.||..|..:|:
Frog   601 TDSVTLSWT-TPNDINKGSYYYLITTACGTTTCN-----VNSTVNANGATVASLLPGLTYQFSVY 659

  Fly   882 TVS--GGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAP----AGEYTDFELQYLSADEE 940
            ||:  |..:|..........|...:.:....|....::::||.|    ...|| :.:.:...:|
Frog   660 TVTSDGTNSSAFASTSGTTAPNAPTSVSGNPVNTTALSVNWTPPNDLNKNNYT-YTVFWQRNNE- 722

  Fly   941 APQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTA 1005
              .|.|::|.||.| :.||...:.|                 :|||.:::.:...:.|.....|.
Frog   723 --SLNQSITSNTTI-IGGLTAGNQY-----------------NVSVISVINNVPSVKAVAYLQTN 767

  Fly  1006 P--PGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKI 1068
            |  ||.   |:...:....|...|::........|:.      ||.......:.:|...:::|.:
Frog   768 PEVPGG---FKIVTITNSSVNVSWTIPSGGSFSGIEI------NAVSGTSNLTKQFTGPSSEGIL 823

  Fly  1069 DGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIE-ISFRQGYF 1132
            |||:||..|...:::.|:.                     ||.:...:||.::|.. |::.....
Frog   824 DGLIPGTAYNLILRSFSSY---------------------PSGSSGRISRRATTNNIITYSNPII 867

  Fly  1133 SNAHGMVRSYTIIIAEDVGKNASGLEM------PSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRK 1191
            ........:.|.|....||   .|.::      ||..          |.:|:     :.::|:.|
Frog   868 EKVQLDPNTVTGITCTKVG---GGYQLKVAFVCPSGS----------YSSIK-----ILADGNEK 914

  Fly  1192 SSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTV--YSSPITTERSDTV 1254
            .::.|:       ||.:   |.....|:..|.|.|.:....|..:.:|.:  |:..:      .|
Frog   915 ETIPAQ-------NCSQ---GATVQSLQPATKYIITVETVADSRQVSDFIICYTDNV------GV 963

  Fly  1255 IVAATVSAVLLVAMVLVVVYCQHRCQLIRRASK------LARMQD-ELAALPEGYITPNRPVHVK 1312
            ||.:....:|.:.:|.::.|...|   .||.||      ...||. .:..:|.        |...
Frog   964 IVGSIFGVLLFLLVVGLIAYFVLR---KRRGSKNPFKKERGNMQKINIVRMPS--------VMKS 1017

  Fly  1313 DFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDD 1377
            .|.::|:...|||||.|:||:::|.:||.:|:...|.|..||.||||||:|||||||.:|..:|.
Frog  1018 AFPDYYQRQHADSDFGFAEEYQQLSNVGINQSKLAAELSENRSKNRFTNVLPYDHSRVRLNRIDA 1082

  Fly  1378 DDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYW 1442
            |:.|||||||||||:||.:|||.:||||.:|..:||||.||:....|||||.|.|.||.||:.||
Frog  1083 DETSDYINANYMPGYNSSKEFIASQGPLPNTSADFWRMIWENQVSTIVMLTNCMENGRVKCEHYW 1147

  Fly  1443 PVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV--SRNCESRIMRHFHFTTWPDFGVPEPPQSLVR 1505
            |:|.....||||.|.:..:....||::.:|.:  ::...::..||||||.|||.||||...::|.
Frog  1148 PLDYTPCTYGDITVTVTSEMILPDWTVRDFTLKHAKQQGNKHARHFHFTVWPDHGVPENTTTIVE 1212

  Fly  1506 F---VRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFM 1567
            |   ||.:.| :.....|.:|||||||||:||.||||.::|.:.|...:.|:..|..||:.|..|
Frog  1213 FRNLVREYMD-LKRSSGPTVVHCSAGVGRTGTLIALDYLIQKMEKEQRIGIYSFVQKMRQNRPLM 1276

  Fly  1568 VQTEQQYVCIHQCLLAVLE 1586
            ||||.|||.:::|:|.:::
Frog  1277 VQTESQYVFLNKCMLDLIQ 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	8/24 (33%)
		fn3	247..328	CDD:278470	22/88 (25%)
		fn3	343..417	CDD:278470	18/78 (23%)
		fn3	443..525	CDD:278470	17/83 (20%)
		FN3	548..611	CDD:238020	16/65 (25%)
		FN3	620..706	CDD:238020	21/93 (23%)
		fn3	708..796	CDD:278470	22/101 (22%)
		fn3	824..886	CDD:278470	19/68 (28%)
		fn3	902..978	CDD:278470	16/79 (20%)
		fn3	1013..1092	CDD:278470	15/78 (19%)
		UP_III_II	1106..>1248	CDD:297589	28/150 (19%)
		PTPc	1329..1582	CDD:214550	127/257 (49%)
		PTPc	1355..1582	CDD:238006	116/231 (50%)
ptprh	XP_012822947.2	FN3	36..113	CDD:214495	26/105 (25%)
		FN3	128..205	CDD:214495	20/85 (24%)
		FN3	220..297	CDD:214495	19/86 (22%)
		FN3	312..390	CDD:238020	15/77 (19%)
		fn3	406..481	CDD:394996	15/74 (20%)
		FN3	496..573	CDD:214495	20/93 (22%)
		FN3	588..665	CDD:214495	22/87 (25%)
		FN3	680..757	CDD:238020	20/98 (20%)
		FN3	771..837	CDD:419708	16/74 (22%)
		R-PTPc-H	1062..1294	CDD:350467	116/232 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010